P-selectin glycoprotein ligand-1
The metabonomics study of P-selectin glycoprotein ligand-1 (PSGL-1) deficiency inhibiting the progression of atherosclerosis in LDLR-/- mice
... PSGL-1, P-selectin glycoprotein ligand-1; NMR, nuclear magnetic resonance; CPMG, Carr-Purcell- Meiboom-Gill; FIDs, free-induction decays; PCA, principal component analysis; ...
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Generation of soluble P and E selectins in vivo is dependent on expression of P selectin glycoprotein ligand 1
... soluble P- and E-selectins remain ...lacking P-selectin glycoprotein ligand-1 (Psgl-1 )/) ) are deficient in soluble P-selectin (sP-sel), which is due to a ...
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P selectin glycoprotein ligand 1–deficient mice have impaired leukocyte tethering to E selectin under flow
... Generation of PSGL-1–deficient mice. Electroporation was used to transfect the targeting vector into CJ7 ES cells (originating in a 129/SvlmJ mouse, a gift from Thomas Sato, University of Texas Southwestern Med- ...
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Activation of polymorphonuclear leukocytes reduces their adhesion to P selectin and causes redistribution of ligands for P selectin on their surfaces
... with P-selectin, or by other signaling ...to P-selectin, when compared to up-regulation of CD11/CD18 integrins, suggests that "bond trading" may occur as activated PMNs transmigrate in ...
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Selectin and selectin ligand binding: a bittersweet attraction
... neous lymphocyte-associated antigen (CLA), binds to all three selectins and appears to be an interesting drug tar- get. Its expression by T cells requires the action of multiple glycosyltrans- ferases such as core 2 β ...
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Neutrophils use both shared and distinct mechanisms to adhere to selectins under static and flow conditions
... Both P-selectin glycoprotein ligand-1 (PSGL-1) and L-selectin are localized on the microvilli of neutrophils and have been implicated in the attachment of neutrophils to ...
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Extracellular vesicles: how they interact with endothelium, potentially contributing to metastatic cancer cell implants
... their P-selectin glycoprotein ligand-1 and exposed phosphatidylserine, the latter of which is normally hidden on the inner bilayer of the intact cellular ...
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Neutrophil neutrophil interactions under hydrodynamic shear stress involve L selectin and PSGL 1 A mechanism that amplifies initial leukocyte accumulation of P selectin in vitro
... mucin glycoprotein can be recognized by all three selectin members, and participates in leukocyte–leukocyte, leukocyte– endothelial cell, and leukocyte–platelet ...a ligand for L-selectin ...
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The cytokine adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney Inhibition by a soluble P selectin ligand
... of P-selec- tin, which is rapidly translocated to endothelial cell surfaces within 5 min of revascularization of the organ, initiating steps leading to tethering of PMNs to the vascular intima ...induces P- ...
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P selectin is a host receptor for Plasmodium MSP7 ligands
... (P-Selectin Glycoprotein Lig- and 1) [11]. Patients deficient in P-selectin function suffer from persistent bacterial infections, demonstrating the im- portance of this protein ...
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Leukocyte infection by the granulocytic ehrlichiosis agent is linked to expression of a selectin ligand
... Human granulocytic ehrlichiosis (HGE) is an emerging tickborne illness caused by an intracellular bac- terium that infects neutrophils. Cells susceptible to HGE express sialylated Lewis x (CD15s), a ligand for ...
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Original Article Expression of P-selectin, VCAM-1, and PSGL-1 in traumatic deep venous thrombosis
... tested P-selectin, VCAM-1, and PSGL-1 mRNA and protein expression in blood and vena cava wall ...test P-selectin, VCAM-1, and PSGL-1 mRNA expression in ...detect ...
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P selectin deficiency exacerbates experimental glomerulonephritis: a protective role for endothelial P selectin in inflammation
... Induction of GN and collection of urine, serum, and kidneys. Nephro- toxic serum was prepared by immunizing rabbits with mouse GBM, as described by Schrijver et al. (28). Male mice 8–12 weeks old were immunized ...
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Monocyte tethering by P selectin regulates monocyte chemotactic protein 1 and tumor necrosis factor alpha secretion Signal integration and NF kappa B translocation
... In contrast, we found that tethering of PMNs to purified P-selectin, or to transfected cells that express P-selectin, allows rapid activation events inside-out signaling of /2 integrins,[r] ...
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Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion
... a selectin-binding carbohydrate (fucoidin) on the increased rolling and adhesion of leukocytes in postischemic ...and/or P-selectin to leukocyte rolling were also assessed in this ...
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P-Selectin-Mediated Adhesion between Platelets and Tumor Cells Promotes Intestinal Tumorigenesis in ApcMin/+ Mice
... on P-selectin (CD62P), a cell adhesion molecule that is abundantly expressed on activated ...of P-selectin suppressed intestinal tumor growth, which was rescued by the infusion of wild-type ...
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CdTe quantum dots induce activation of human platelets: implications for nanoparticle hemocompatibility
... acid provides a negative surface charge, and cysteamine provides a positive surface charge to the QDs. Hereinafter, they are referred to as “negatively” and “positively” charged CdTe QDs. A UV-1601 UV-Visible ...
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Characterisation of P glycoprotein 9 1 in Haemonchus contortus
... RNA was extracted from stable transfectants using the RNeasy extraction kit, following the manufacturer’s in- structions as above. Subsequently, a reverse transcription- PCR was done with the extracted RNA. Then, the ...
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Role of P-Selectin in Patients with Slow Coronary Flow
... in P-selectin level between group 1(primary coronary slow flow patients) and group 2 (normal coronary angio patients) and there was a statistically significant association between ...
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Anti P selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear
... of P-selectin in PMN-mediated injury after reperfusion of the rabbit ...murine P-selectin mAbs, designated ...rabbit P-selectin and prevents histamine-induced leukocyte rolling, ...
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