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Radiation therapy-induced reactive oxygen species specifically eliminates CD19+ IgA+ B cells in nasopharyngeal carcinoma

<p>Radiation therapy-induced reactive oxygen species specifically eliminates CD19<sup>+</sup>&nbsp;IgA<sup>+</sup>&nbsp;B cells&nbsp;in nasopharyngeal carcinoma</p>

... tumor cells caused by RT could be reduced using various anti-ROS ...cancer cells can utilize changes in ROS metabolism activity to resist radia- tion ...cancer cells can perform a series of actions ...

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Evaluating Nephrocheck&reg; as a Predictive Tool for Acute Kidney Injury

<p>Evaluating Nephrocheck<sup>&reg;</sup> as a Predictive Tool for Acute Kidney Injury</p>

... 11,12 Cells react to injury by repairing while entering and exiting different phases of proliferation assisted by ...of cells with damaged DNA, allowing an adequate repair (Figure ...The p-proteins ...

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Comparison of transcriptional profiles in human lymphocyte cells irradiated with 12C ion beams at 0&ndash;2.0 Gy

<p>Comparison of transcriptional profiles in human lymphocyte cells irradiated with <sup>12</sup>C ion beams at 0&ndash;2.0 Gy</p>

... An optimized microarray platform was used to analyze and compare gene expression patterns between irradiated and control cells. In total, 504 mRNAs exhibited significantly different expression levels among the ...

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Thioperamide induces CD4+ CD25+ Foxp3+ regulatory T lymphocytes in the lung mucosa of allergic mice through its action on dendritic cells

Thioperamide induces CD4<sup>+</sup> CD25<sup>+</sup> Foxp3<sup>+</sup> regulatory T lymphocytes in the lung mucosa of allergic mice through its action on dendritic cells

... dendritic cells, or thioperamide-treated dendritic ...dendritic cells and T lymphocytes, as well as the expression of H and H4 receptors in mononuclear lung ...T cells in the lungs of allergic mice ...

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A Synthetic Peptide 2Abz23S29 Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection

<p>A Synthetic Peptide 2Abz<sup>23</sup>S<sup>29</sup> Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection</p>

... against microbial invasion. These cytokines are important for the clearance of UPEC and the recruitment of neutrophils. 5 Human C-X-C ligand 8 (IL-8) is the major chemokine for neutrophil recruitment during UTI, which is ...

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An Immunoscore System Based On CD3+ And CD8+ Infiltrating Lymphocytes Densities To Predict The Outcome Of Patients With Colorectal Adenocarcinoma

<p>An Immunoscore System Based On CD3<sup>+</sup> And CD8<sup>+</sup> Infiltrating Lymphocytes Densities To Predict The Outcome Of Patients With Colorectal Adenocarcinoma</p>

... consists of many types of leukocytes such as macrophages, natural killer (NK), B lymphocytes, cytotoxic and memory T lymphocytes. Naito et al 10 were the fi rst showing that CD8 + cytotoxic T-cells represent a ...

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Solutol&reg;HS15+pluronicF127 and Solutol&reg;HS15+pluronicL61 mixed micelle systems for oral delivery of genistein

<p>Solutol<sup>&reg;</sup>HS15+pluronicF127 and Solutol<sup>&reg;</sup>HS15+pluronicL61 mixed micelle systems for oral delivery of genistein</p>

... atmosphere and supplemented with 10% fetal bovine serum (FBS), 1% nonessential amino acids (NEAA), 1% L-glutamine, 100 μ g • mL −1 penicillin, and 100 U • mL −1 streptomycin. Caco-2 cell suspensions were grown in a ...

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PD-1 blockade restores impaired function of ex vivo expanded CD8+ T cells and enhances apoptosis in mismatch repair deficient EpCAM+PD-L1+ cancer cells

PD-1 blockade restores impaired function of ex vivo expanded CD8<sup>+</sup> T cells and enhances apoptosis in mismatch repair deficient EpCAM<sup>+</sup>PD-L1<sup>+</sup> cancer cells

... Background: Adoptive T cell therapy has been proven to be a promising modality for the treatment of cancer patients in recent years. However, the increased expression of inhibitory receptors could negatively regulate the ...

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Downregulation of CD44 reduces doxorubicin resistance of CD44+CD24- breast cancer cells

Downregulation of CD44 reduces doxorubicin resistance of CD44<sup>+</sup>CD24<sup>-</sup> breast cancer cells

... single cells surrounding the tumor tissue. Cells from 15 samples were left to freely propagate until the cul- ture reached 80% ...single cells appeared around day 5, with the earliest at day ...

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EDNRB isoform 3 confers Temozolomide resistance in A375 melanoma cells by modulating membrane potential, reactive oxygen species and mitochondrial Ca2+

<p>EDNRB isoform 3 confers Temozolomide resistance in A375 melanoma cells by modulating membrane potential, reactive oxygen species and mitochondrial Ca<sup>2+</sup></p>

... Melanoma is the most dangerous form of skin cancer and its incidence is increasing fast. 1 Five-year survival rates of advanced stage of melanoma are less than 10%. 2 Temozolomide (TMZ) is one of the alkylating agents ...

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N-n-butyl haloperidol iodide inhibits H2O2- induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes

<em>N</em>-n-butyl haloperidol iodide inhibits H<sub>2</sub>O<sub>2</sub>- induced Na<sup>+</sup>/Ca<sup>2+</sup>-exchanger activation via the Na<sup>+</sup>/H<sup>+</sup> exchanger in rat ventricular myocytes

... Total protein extracts were prepared from cells using cell- lysis buffer containing a protease-inhibitor cocktail (aprotinin, leupeptin, pepstatin A, and phenylmethylsulfonyl fluoride). The protein concentration ...

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PD-1 inhibitors dependent CD8+ T cells inhibit mouse colon cancer cell metastasis

<p>PD-1 inhibitors dependent CD8<sup>+</sup> T cells inhibit mouse colon cancer cell metastasis</p>

... + cells in MLNs and ...T cells and forms a complex with the T cell antigen receptor (TCR) to transmit the antigen signal to the ...+ cells in MLNs and spleen of colon cancer mice, ...

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Pretreatment detection of circulating and tissue CD133+&nbsp;CD44+ cancer stem cells as a prognostic factor affecting the outcomes in Egyptian patients with colorectal cancer

<p>Pretreatment detection of circulating and tissue CD133<sup>+&nbsp;</sup>CD44<sup>+</sup> cancer stem cells as a prognostic factor affecting the outcomes in Egyptian patients with colorectal cancer</p>

... which cells are neither dividing nor preparing to divide, ie, quiescent, and can be considered as extended G1 phase; cells remain in G1 phase for a bit less than half of the total cell cycle ...other ...

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Inflammatory Responses of Bovine Polymorphonuclear Neutrophils Induced by Staphylococcal Enterotoxin C via Stimulation of Mononuclear Cells

Inflammatory Responses of Bovine Polymorphonuclear Neutrophils Induced by Staphylococcal Enterotoxin C via Stimulation of Mononuclear Cells

... In the dairy industry, staphylococcal mastitis causes enor- mous economic losses through discards of contaminated milk and reductions of milk yields (6). In many cases, staphylococci cause subclinical and/or chronic ...

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Highly Efficient Targeting of EGFR-Expressing Tumor Cells with UniCAR T Cells via Target Modules Based on Cetuximab&reg;

<p>Highly Efficient Targeting of EGFR-Expressing Tumor Cells with UniCAR T Cells via Target Modules Based on Cetuximab<sup>&reg;</sup></p>

... tumor cells (Figure 4), we also tested tumor cells with an intermediate (Figure S2) and low EGFR expression (Figure ...T cells can be effec- tively redirected by the scFv-based TMs towards tumor ...

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LncRNAs NR-026690 and ENST00000447867 are upregulated in CD4+ T cells in patients with acute exacerbation of COPD

<p>LncRNAs NR-026690 and ENST00000447867 are upregulated in CD4<sup>+</sup> T cells in patients with acute exacerbation of COPD</p>

... It has been proposed that genes with the same function or in the same pathway would be co-expressed, and co-expressed network has been used to predict the potential function of lncRNAs based on this hypothesis. ...

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Assessment of Acceptability and Ease of Use of Haemoglobin Spray (Granulox&reg;) in the Management of Chronic Wounds

<p>Assessment of Acceptability and Ease of Use of Haemoglobin Spray (Granulox<sup>&reg;</sup>) in the Management of Chronic Wounds</p>

... In an acute wound, the disruption of capillaries leads to a transient local decrease of oxygen within the wound result- ing in inadequate oxygenation of the tissue (hypoxia). It is well known that hypoxia serves as one ...

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Efficacy and safety of tiotropium + olodaterol maintenance treatment in patients with COPD in the TONADO&reg; and OTEMTO&reg; studies: a subgroup analysis by age

<p>Efficacy and safety of tiotropium + olodaterol maintenance treatment in patients with COPD in the TONADO<sup>&reg;</sup> and OTEMTO<sup>&reg;</sup> studies: a subgroup analysis by age</p>

... years, n=749; 65 years to ,75 years, n=674; 75 years to ,85 years, n=186; $85 years, n=12) in OTEMTO and 5,162 patients (40 years to ,65 years, n=2,654; 65 years to ,75 years, ...

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On λ statistical convergence and strongly λ summable functions of order α

On λ statistical convergence and strongly λ summable functions of order α

... strong p-Cesàro convergence of a sequence of real numbers were introduced in the literature independently of one another and fol- lowed different lines of development since their first ...

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Remicade&reg;&nbsp;(infliximab):&nbsp;20 years of contributions to science and medicine

<p>Remicade<sup>&reg;</sup>&nbsp;(infliximab):&nbsp;20 years of contributions to science and medicine</p>

... Thus, the phase II/III program had answered all three initial questions about long-term TNF blockade with Remicade: 1) mAbs could be administered repeatedly as maintenance therapy, and s[r] ...

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