p-tau
Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels
... Data and methods for the rQTL and G×G analyses For the rQTL and G×G analyses, the dataset for CSF biomarker analysis consisted of 3146 participants from nine different studies and is described in detail in our recent ...
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Comparing 18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease
... CSF tau and PET tau measures correlate, 6,10 but those results stem from populations mainly consisting of controls, including few cases with AD ...PET tau measures have similar or different di- ...
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Cerebrospinal fluid Aβ42, t-tau, and p-tau levels in the differential diagnosis of idiopathic normal-pressure hydrocephalus: a systematic review and meta-analysis
... and p-tau have been widely validated as CSF biomarkers for AD ...CSF p-tau and t-tau is strongly asso- ciated with AD ...[10]. Tau is an intracellular microtubule- associated ...
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CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau
... and tau markers interrelated in several studies of AD cohorts, yet in different subpopulations [19, 20, ...of p-tau in linear regression analyses showed that p-tau was the best sole ...
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Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein
... for P-Tau and a combination of Mabs 2E1, 1B4, 4A11 for GFAP (BD Pharmingen (Franklin Lakes, ...for Tau and a rabbit anti-GFAP polyclonal Ab (Abcam, Cambridge, MA) for ...of Tau and GFAP in ...
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The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer’s disease
... t-tau, p-tau, A β 42, sAPP α and sAPP β were analyzed with methods described elsewhere [11, 17, 18] or by the manufacturer (NF-light ELISA kit; Uman Diagnostics AB, Umeå, Sweden) and results are ...
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Potential biomarkers relating pathological proteins, neuroinflammatory factors and free radicals in PD patients with cognitive impairment: a cross-sectional study
... biomarker. P-tau is found in AD patients, however, there is no research on the relationship between P-tau level in CSF and PD-CI so ...of P-tau (S199), P-tau (T181) ...
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Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice
... clearing tau with specific mAbs; reducing the effector function may offer a safer approach for targeting tau by avoiding engagement of microglia that may induce an inflammatory response but still achieving ...
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Evaluation of coexistence of Alzheimer’s disease in idiopathic normal pressure hydrocephalus using ELISA analyses for CSF biomarkers
... AD and iNPH have different pathomechanism, but recent studies pointed out common pathomechanism between the two diseases [5,6]. However there is still controversy about the clinical implications of the coexist- ence of ...
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Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration
... In humans, structural MRI and CSF biomarkers allow for the indirect assessment of the cellular changes underlying AD in vivo. Structural MRI provides measures of brain at- rophy, which reflect loss of dendrites, synapses ...
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The high affinity HSP90 CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
... (anti–S262/S356 p-tau) from ...(anti–S396/S404 p-tau) and CP13 (S202/T205 p-tau) were provided by ...USA. Tau 5 (anti–total tau) was provided by ...
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The CSF neurofilament light signature in rapidly progressive neurodegenerative dementias
... (or p-tau/t-tau) ratio; and, more recently, the prion real-time quaking-induced con- version (RT-QuIC) assay [8, 12 – ...t-tau, p-tau, β -amyloid 42 (A β 42 ), ...
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Genome-wide association reveals genetic effects on human Aβ 42 and τ protein levels in cerebrospinal fluids: a case control study
... can be used to aid in diagnosis and to predict progres- sion from mild cognitive impairment (MCI) to AD [18,19]. These biomarkers can potentially be used in future applications to predict the development of MCI in ...
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Recent progress and concerns in dementia: Distinguishing Alzheimer's disease and dementia with Lewy bodies via biochemical markers in the cerebrospinal fluid
... Intense multidisciplinary research has provided detailed knowledge of the molecular pathogenesis of neurode- generative diseases, including Alzheimer’s dementia and dementia with Lewy bodies. Among these, pathology- ...
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<p>Higher Plasma APOC-III Was Associated with a Slower Reduction of β-Amyloid Levels in Cerebrospinal Fluid Among Older Individuals Without Dementia</p>
... First, we applied Kruskal – Wallis tests and x2 tests to assess differences in demographic and clinical variables across the tertiles of APOC-III levels. Second, to examine the cross- sectional relationships between ...
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Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases
... of tau, p-tau (Ser396), p-tau (Ser404), p-tau (Ser202/Thr205), GSK3β and CDK5 in the brains of scrapie-infected hamsters dur- ing incubation period, the expressive and ...
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APOE ε4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals – a cross-sectional observational study
... -.50; p = .001) and multivariate analyses (R 2 = .25; p < ...of p-tau in univariate analyses (r = .32; p = ....10; p = ...( p = .05) and past HIV-associated dementia ( ...
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Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals
... hyperphosphorylated tau (P-tau), total tau (T-tau), neurogranin, SNAP-25, glial fibrillary acidic protein (GFAP), YKL-40, and especially neurofilament light (NfL) are frequently ...
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<p>The Regulating Mechanism of Chrysophanol on Protein Level of CaM-CaMKIV to Protect PC12 Cells Against Aβ<sub>25-35</sub>-Induced Damage</p>
... CaMKIV, p-CaMKIV, tau, and p-tau protein were detected by Western ...CaMKIV, p-CaMKIV, tau, p-tau (1:1000, Cell Signaling Technology, MA, USA) at 4°C ...
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Original Article Proteasome degradation of brain cytosolic tau in Alzheimer’s disease
... studied tau pathology in 30 prospectively followed patients from the Mayo Clinic Alzheimer Disease Re- search Center grouped by cognitive ...undigested tau was studied in temporal and frontal cortical ...
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