P. yoelii
Unlike the synchronous <em>Plasmodium falciparum</em> and <em>P. chabaudi</em> infection, the <em>P. berghei</em> and <em>P. yoelii</em> asynchronous infections are not affected by melatonin
... synchronize P. berghei and P. yoelii, we incubated parasites with various melatonin concentra- ...for P. berghei, and 250 μ M for P. yoelii, in contrast to that is found in ...
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Plasmodium yoelii infection inhibits murine leukaemia WEHI-3 cell proliferation in vivo by promoting immune responses
... the P. yoelii 17XNL strain does not induce fever in rodent malaria [19], and we did not observe fever in the animals in our study (data not ...of P. yoelii 17XNL infection is not associated ...
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Differential activity of methylene blue against erythrocytic and hepatic stages of Plasmodium
... of P. yoelii- infected mice; however this effect was observed only at the highest doses and was not sufficient to prevent tran- sition to a blood stage ...
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Plasmodium yoelii 17XL infection up regulates RANTES, CCR1, CCR3 and CCR5 expression, and induces ultrastructural changes in the cerebellum
... with P. yoelii 17XL-parasitized erythrocytes have been shown to be induced to produce and present specific chemokines, such as RANTES, which can lure CCR1, CCR3 and CCR5 expressing cells into the brain ...
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A highly infectious Plasmodium yoelii parasite, bearing Plasmodium falciparum circumsporozoite protein
... of P. yoelii 17XNL strain [23] was performed by the same procedures as described previously [24] except that a discontinuous gradient of Percoll/sorbitol (60/40 %) was used for purification of mature ...
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Larval nutrition differentially affects adult fitness and Plasmodium development in the malaria vectors Anopheles gambiae and Anopheles stephensi
... effected mortality in An. stephensi by P. yoelii. Similarly, Dawes et al. [9] report a density-dependent effect of P. berghei ookinetes in An. stephensi. Other reasons could be the small blood meal ...
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Apoptosis of non parasitized red blood cells in malaria: a putative mechanism involved in the pathogenesis of anaemia
... As expected, P. yoelii 17XL infection was marked by an accentuated anaemia degree and it was lethal to Balb/c mice [15,16]. Infected mice started to die on day 7 post-infection with parasitaemia rates of ...
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A Plasmodium yoelii soluble factor inhibits the phenotypic maturation of dendritic cells
... late P. yoelii infection the regulatory DC subset is the dominant DC population in the spleen, therefore the data presented here mainly reflect the behavior of this ...and P. yoelii-infected ...
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In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection
... both P. berghei and P. yoelii efficiently infect and com- plete liver stage development in C57BL/6 mice, with injection of 1,000 sporozoites of either species being sufficient to ensure blood stage ...
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Anti malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii
... of P. yoelii 17XL occurred in all the drug treated mice, it is highly unlikely that it can be due to a mutation in Pyebl ...of P. yoelii 17XL to identify the molecular players that participate ...
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Allicin enhances host pro inflammatory immune responses and protects against acute murine malaria infection
... Another aspect of allicin’s immunomodulatory effect is down-regulation of pro-inflammatory response. Allicin could reduce the TNF level in a dose-dependent manner and suppress both spontaneous and TNF stimulated ...
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Interactions between a fungal entomopathogen and malaria parasites within a mosquito vector
... the P. yoelii experiment, the mosquitoes were exposed to either fungus-treated or control tiles at two time points following the blood feed, generating four treatment groups (dual infection, fungal ...
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Nuclear, Cytosolic, and Surface-Localized Poly(A)-Binding Proteins of Plasmodium yoelii
... Little has been experimentally discovered about PABPs in Plasmodium species. However, previous studies of Plasmodium falciparum have identified and bioinformati- cally characterized one PABP (PfPABP) that has the ...
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Chemically attenuated blood-stage Plasmodium yoelii parasites induce long-lived and strain-transcending protection
... the P. yoelii vaccine containing all the blood stages, whereas the ...the P. yoelii vaccine than in spleens of control mice, suggesting the induction of T cell-depen- dent antibody responses ...
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Identification of two new protective pre erythrocytic malaria vaccine antigen candidates
... from P. yoelii (17XNL) genomic DNA by PCR with the primers, 5 ’ -TGGATCCATGAAAGTGTATAAAATGAA- CACTCTC-3 ’ and 5 ’ -TGGATCCTCATTTTGGTTGA- TATTGTTCTTTAAG-3 ’ ...
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Plasmodium yoelii Erythrocyte Binding like Protein Modulates Host Cell Membrane Structure, Immunity, and Disease Severity
... Plasmodium yoelii has one EBL gene (Pyebl), encoding a protein (PyEBL) with a single DBL domain ...of P. yoelii (10), which may help maintain normal invasion of RBCs but cannot explain the enhanced ...
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Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood
... that P. yoelii sporo- zoite 18S rRNA does not persistently circulate in periph- eral blood and suggests that timing and concentration of the pre-erythrocytic 18S rDNA positivity 24 h post- challenge in the ...
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In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate
... of P. yoelii M2-MAEBL antisera pool was investi- gated as previous described [39], to recognize blood schizonts of ...b, P. yoelii antisera raised against M2-MAEBL recombinant protein ...
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Suppressive and additive effects in protection mediated by combinations of monoclonal antibodies specific for merozoite surface protein 1 of Plasmodium yoelii
... The mechanism(s) by which these three antibodies pro- vide protection following passive immunization is unknown. There are several mechanisms that have been suggested to explain the protective effect of antibodies to ...
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Long-Lasting Protective Immune Response to the 19-Kilodalton Carboxy-Terminal Fragment of Plasmodium yoelii Merozoite Surface Protein 1 in Mice
... against P. yoelii infection even though some mice experienced some patent parasitemia, but in the presence of CpG ODN 1826, complete protection is ...
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