p21-activated kinase
Inca: a novel p21 activated kinase associated protein required for cranial neural crest development
... a p21-activated kinase downstream of the Rho GTPases Cdc42 and Rac1, previously implicated in cytoskeletal organization and apoptosis (Bokoch, 2003; Jaffer and Chernoff, 2002) as well as control of ...
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Nef Associates with p21-Activated Kinase 2 in a p21-GTPase-Dependent Dynamic Activation Complex within Lipid Rafts
... of p21-activated kinase 2 ...Nef-associated kinase (NAK) complex was found to be due to an autoregu- latory ...with p21-mediated activation rather than kinase activity per se was ...
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A Hydrophobic Binding Surface on the Human Immunodeficiency Virus Type 1 Nef Core Is Critical for Association with p21-Activated Kinase 2
... with p21-activated kinase 2 (Pak2), a cel- lular serine/threonine kinase, has been proposed to play an important role in T-cell activation ...
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Activation of p21-Activated Kinase 2 by Human Immunodeficiency Virus Type 1 Nef Induces Merlin Phosphorylation
... The accessory human immunodeficiency virus type 1 (HIV-1) protein Nef activates the autophosphor- ylation activity of p21-activated kinase 2 (PAK2). Merlin, a cellular substrate of PAK2, is ...
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Original Article p21-activated kinase 4 promotes proliferation, migration, and invasion of human gastric cancer cells
... p21-activated kinase 4 (PAK4) (chromosome 19q13.2) is a member of the serine/threonine kinase family of p21-activated kinases (PAKs). PAKs are involved in a variety of cellular ...
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Pathogenic Escherichia coli Hijacks GTPase Activated p21 Activated Kinase for Actin Pedestal Formation
... activate p21-activated kinase (PAK), a key cytoskeletal regulator, but the function of this interaction and whether it impacts pedestal as- sembly are ...
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Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family.
... p65 kinase, labeled by autophosphorylation in a complex with the modified Nef, was released into solution by elution with the FLAG ...human kinase, since partial digestion of 32 ...
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The p21 activated kinase Mbt is a component of the apical protein complex in central brain neuroblasts and controls cell proliferation
... protein kinase C (aPKC), localizes at the apical cortex and controls the basal localization of cell fate determinants, the orientation of the mitotic spindle along the apico-basal axis and asymmetry of the mitotic ...
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p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta- analysis
... (Cdc42/Rac)-activated kinase 1” / “PAK1” / “PAKalpha”, “cancer” / “tumor” / “neoplasm” / “carcinoma”, and “survival” / “prognosis” / “mortality” / “death” independently in PubMed and Web of ...
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Reconstitution and Molecular Analysis of an Active Human Immunodeficiency Virus Type 1 Nef/p21-Activated Kinase 2 Complex
... a p21 GTPase ...vitro kinase assay was performed ...and p21 GTPase protein expression ...PAK-2 kinase activity associated with Nef ...of activated GTPases endogenous to the cell- free ...
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p21 activated kinase signaling in breast cancer
... constitutively activated in patients with aggressive breast cancer ...PAK kinase activity, was also found to increase membrane ruffling and to upregulate in human breast cancer tissues ...
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p21-activated kinase 1: PAK’ed with potential
... a p21-binding domain (PBD), a serine/threonine kinase domain, an acidic region and multiple proline-rich regions that serve as binding sites for SH3 domain-containing ...
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Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization
... Rho kinase, and this phosphorylation can affect intramolecular association and cellular ...although activated Rho did not induce no- ticeable phosphorylation of merlin, activated forms of Rac and ...
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Neuroimmune modulation following traumatic stress in rats: evidence for an immunoregulatory cascade mediated by c-Src, miRNA222 and PAK1
... (p21-activated kinase 1); and (iii) the association between PAK1 and interleukin 1 b signaling, both in cortex of rats following traumatic stress and in primary cortical ...
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GTPase-Activating Proteins for Cdc42
... The Rho-type GTPase, Cdc42, has been implicated in a variety of functions in the yeast life cycle, including septin organization for cytokinesis, pheromone response, and haploid invasive growth. A group of proteins ...
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Activation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancer
... Objective: p21-activated kinase (PAK) 2, as a member of the PAK family kinases, is involved in a number of hallmark processes including cell proliferation, survival, mitosis, apoptosis, motility and ...
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Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA mediated motor axon guidance
... The small GTPase Rac and its downstream effector p21 activated kinase PAK can regulate receptor GCs to raise cellular cGMP levels in fibroblasts in vitro, and the kinase domain of PAK in[r] ...
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MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts
... protein kinase (MAPK), which subsequently induce sev- eral cellular responses including gene expression and pulmonary fibrosis [14, ...N-terminal kinase (JNK) signaling pathway ...
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Mechanism-Based Screen Establishes Signalling Framework for DNA Damage-Associated G1 Checkpoint Response
... Effect of target silencing on IR-associated cell survival G1 checkpoint activation is thought to play an important role in protecting cells against IR elicited death [6]. Importantly, loss of G1 checkpoint activity was ...
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Screening of potential diagnostic markers and therapeutic targets against colorectal cancer
... These genes with aber- rant methylation included some mitogen-activated protein kinase kinase kinase (MAPKKK)-encoding genes as well as mitogen-activated protein kinase (MAPK)-encoding[r] ...
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