p21-activated kinase (PAK)
A Hydrophobic Binding Surface on the Human Immunodeficiency Virus Type 1 Nef Core Is Critical for Association with p21-Activated Kinase 2
... with p21-activated kinase 2 (Pak2), a cel- lular serine/threonine kinase, has been proposed to play an important role in T-cell activation ...
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Original Article p21-activated kinase 4 promotes proliferation, migration, and invasion of human gastric cancer cells
... Abstract: Background/Aim: p21-activated kinase 4 (PAK4) overexpression has been observed in many cancers, including metastatic gastric cancer (GC). However, the precise role of PAK4 in GC remains ...
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Nef Associates with p21-Activated Kinase 2 in a p21-GTPase-Dependent Dynamic Activation Complex within Lipid Rafts
... of p21-activated kinase 2 ...Nef-associated kinase (NAK) complex was found to be due to an autoregu- latory ...with p21-mediated activation rather than kinase activity per se was ...
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Inca: a novel p21 activated kinase associated protein required for cranial neural crest development
... a p21-activated kinase downstream of the Rho GTPases Cdc42 and Rac1, previously implicated in cytoskeletal organization and apoptosis (Bokoch, 2003; Jaffer and Chernoff, 2002) as well as control of ...
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Activation of p21-Activated Kinase 2 by Human Immunodeficiency Virus Type 1 Nef Induces Merlin Phosphorylation
... The accessory human immunodeficiency virus type 1 (HIV-1) protein Nef activates the autophosphor- ylation activity of p21-activated kinase 2 (PAK2). Merlin, a cellular substrate of PAK2, is ...
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p21 activated kinase signaling in breast cancer
... factors, PAK signaling could also be stimulated by its upstream ...effector PAK, might be constitutively activated in patients with aggressive breast cancer ...Similarly, PAK interacting ...
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Gringel, Alexandra (2009): Regulation podosomaler Adhäsionen in primären humanen Makrophagen durch p21-activated kinase (PAK)-abhängige Signalwege. Dissertation, LMU München: Medizinische Fakultät
... GIT1 PAK aktivieren kann, dieser Prozess jedoch unabhängig von einer direkten Bindung dieser beiden Komponenten ist (Loo et ...müsste PAK auch bei einer unterbundenen α-PIX-GIT1 Bindung nahezu unverändert ...
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The p21 activated kinase Mbt is a component of the apical protein complex in central brain neuroblasts and controls cell proliferation
... Drosophila PAK protein Mushroom bodies tiny (Mbt) is expressed in central brain progenitor cells (neuroblasts) and becomes enriched to the apical cortex of neuroblasts in a cell cycle- and Cdc42-dependent ...
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Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family.
... Nef-associated kinase identify it as a member of the PAK ...mammalian PAK members: (i) rat p65PAK or rat a PAK (36) and human PAK1 (10a) (GenBank accession number U24152), predominantly ex- ...
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p21-activated kinase 1: PAK’ed with potential
... regimen [29]. While erlotinib is approved for use in unselected patients, there is evidence that erlotinib and a related drug, gefitinib, show greater activity and efficacy in cancers that harbour specific mutations in ...
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Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization
... the kinase that phospho- rylates merlin on serine 518, NIH3T3 cells were co-transfected with expression vectors for merlin and the constitutively active forms of Rac/cdc42 kinase ...LIM kinase, ...
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Pathogenic Escherichia coli Hijacks GTPase Activated p21 Activated Kinase for Actin Pedestal Formation
... of PAK by cellular Rho GTPases both concentrates PAK in the membrane and exposes the I ␣ 3 ...active PAK to the site of bacterial attachment. In complex with EspG, PAK is protected from ...
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Reconstitution and Molecular Analysis of an Active Human Immunodeficiency Virus Type 1 Nef/p21-Activated Kinase 2 Complex
... of PAK-2 activation by ...of PAK-2 are actually required for this Nef ...in PAK-2 activation by Nef or that there are alternative cellular ...
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p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta- analysis
... (Cdc42/Rac)-activated kinase 1 (PAK1) is a member of the PAK family of proteins, which are effectors of small Rho GTPases (Cdc42 and Rac1) [1, ...
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Activation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancer
... Objective: p21-activated kinase (PAK) 2, as a member of the PAK family kinases, is involved in a number of hallmark processes including cell proliferation, survival, mitosis, apoptosis, ...
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Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA mediated motor axon guidance
... The small GTPase Rac and its downstream effector p21 activated kinase PAK can regulate receptor GCs to raise cellular cGMP levels in fibroblasts in vitro, and the kinase domain of PAK in[r] ...
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GTPase-Activating Proteins for Cdc42
... The Rho-type GTPase, Cdc42, has been implicated in a variety of functions in the yeast life cycle, including septin organization for cytokinesis, pheromone response, and haploid invasive growth. A group of proteins ...
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Neuroimmune modulation following traumatic stress in rats: evidence for an immunoregulatory cascade mediated by c-Src, miRNA222 and PAK1
... where p21-activated kinase 1 (PAK1) is one of its targets ...by activated cells of the innate immune system such as monocytes, macro- phages, and brain microglia - plays an important role in ...
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Mechanism-Based Screen Establishes Signalling Framework for DNA Damage-Associated G1 Checkpoint Response
... and p21 CIP1/WAF1 (group I) co-clustered with TP53 knockdown, a second group containing DYRK1A, PRKACG and HK1 (group II) aligned separately from the former (Figure ...consequential p21 CIP1/WAF1 induction ...
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MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts
... receptor-like kinase 5; AP-1: Activator protein-1; BM: Bone marrow; ChIP: Chromatin immunoprecipitation; CTGF: Connective tissue growth factor; CXCR4: CXC receptor 4; ECM: Extracellular matrix; ERK: Extracellular ...
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