P300/CBP-Associated Factor
Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain
... The P300/CBP-associated factor plays a central role in retroviral infection and cancer development, and the C-terminal bromodomain provides an opportunity for selective ...
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RACK1 is a candidate gene associated with the prognosis of patients with early stage non-small cell lung cancer
... were associated with both OS and DFS with P L-R < ...rs2287845T>C, p300/CBP-associated factor [PCAF] rs17006625A>G, and pericentriolar material 1 [PCM1] rs17691523C>G) were ...
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Down Regulation of the Interleukin-8 Promoter by Human Papillomavirus Type 16 E6 and E7 through Effects on CREB Binding Protein/p300 and P/CAF
... coactivators p300 and CBP, causing the modulation of the transcription of certain genes controlled by NF- B (p65 or relA) and ...necrosis factor alpha and requires the cooperation of the ...
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Transcription Factor YY1 and Its Associated Acetyltransferases CBP and p300 Interact with Hepatitis Delta Antigens and Modulate Hepatitis Delta Virus RNA Replication
... acetyltransferases CBP and p300 associate and form large nuclear complexes with both LHDAg and SHDAg in vivo ...YY1, CBP, p300, B23, and ...of CBP, p300, or nucleolin in the HDV ...
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The HTLV 1 Tax interactome
... HATs: p300, its homologous CREB binding protein (CBP) and p300/CBP associated factor (P/CAF) ...the CBP/p300 and P/CAF once the Tax1-CREB- TxRE complex is ...
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A CRISPR Interference of CBP and p300 Selectively Induced Synthetic Lethality in Bladder Cancer Cells In Vitro
... paralogs, CBP and p300 are identified as a promising paralog for targeting therapy in cancer ...treatment. CBP and p300 are homologous transcriptional coactivator which possesses histone ...
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Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53
... pathways associated with tumor progression ...stress factor within the tumour microenvironment to induce increased amounts of EVs from melanoma cells ...
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Latent viruses can cause disease by disrupting the competition for the limiting factor p300/CBP
... A recent paper by Zuo et al. [10] showed that the copy number of latent EBV, a virus that binds GABP•p300/CBP during latency, is strongly associated with oncogenicity [11, 12]. What determines the ...
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Human Immunodeficiency Virus Type 1 (HIV-1) Accessory Protein Vpr Induces Transcription of the HIV-1 and Glucocorticoid-Responsive Promoters by Binding Directly to p300/CBP Coactivators
... homologous p300 and CBP, may serve as macromolecular docking platforms for transcription factors from several signal transduction cascades, including, in addi- tion to nuclear receptors, CREB, AP-1, NF-B, ...
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Green tea polyphenol treatment is chondroprotective, anti inflammatory and palliative in a mouse posttraumatic osteoarthritis model
... was associated with reduced staining for aggrecan and type II collagen cleavage epitopes, and reduced staining for MMP-13 and ADAMTS5 in the articular ...necrosis factor alpha (Tnfa) mRNA and elevated gene ...
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CREB-Binding Protein and Histone Deacetylase Regulate the Transcriptional Activity of Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50
... growth factor  receptor-activated Smad 2 and 4 signaling proteins move into the nucleus and associate with CBP to activate transcription, while activated Smads can also be in- duced by tumor growth ...
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Recruitment of CBP/p300, TATA-Binding Protein, and S8 to Distinct Regions at the N Terminus of Adenovirus E1A
... for CBP, p300, TATA-binding protein (TBP), S4, S8, hGcn5, P/CAF, and Ran within the first 30 amino acids of the Ad5 12S E1A ...or CBP/p300 can exist as functional complexes, RNA interference ...
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Two Independent Regions of Simian Virus 40 T Antigen Increase CBP/p300 Levels, Alter Patterns of Cellular Histone Acetylation, and Immortalize Primary Cells
... binds CBP/p300 and that SVT complements adenovirus E1A mutants defective for CBP/p300 association in transformation assays ...with CBP/p300 requires SVT binding to p53, and ...
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Regulation of DNA Damage Processing by Covalent Modification of Thymine DNA Glycosylase
... transcription factor unwinds approximately 30 base pairs surrounding the lesion, at which point xeroderma pigmentosum complementation group A (XPA) verifies that repair is needed ...
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p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization
... We next investigated the molecular mechanism by which A-485 ameliorated the inflammatory response in the macrophage model challenged by LPS. To gain a more global view of gene expression changes after A-485 treatment, we ...
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The Kaposi's Sarcoma-Associated Herpesvirus K8 Protein Interacts with CREB-Binding Protein (CBP) and Represses CBP-Mediated Transcription
... and CBP. (A) The coimmunoprecipitation of in vivo-synthesized K8 and CBP was analyzed by Western ...HA-tagged CBP expression vector and either a blank (pEBG) vector or an expression vector carrying ...
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HIV-1 Nef-induced lncRNA AK006025 regulates CXCL9/10/11 cluster gene expression in astrocytes through interaction with CBP/P300
... be associated with HIV-asso- ciated neurocognitive disorders (HAND) that is charac- terized by degenerative loss of neurons and ultimately develops into HIV-associated dementia (HAD), the most severe form ...
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Varicella-Zoster Virus Activates CREB, and Inhibition of the pCREB-p300/CBP Interaction Inhibits Viral Replication In Vitro and Skin Pathogenesis In Vivo
... The purpose of this study was to investigate the consequences of disrupting pCREB transcriptional activity on VZV infection, us- ing fibroblasts in vitro and human tissue xenografts in SCID mice as an in vivo system to ...
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Integration as a two-way process in the EU? Assessing the Relationship between the European Integration Fund and the Common Basic Principles on Integration. CEPS Paperbacks, July 2011
... This section provides new perspectives as regards the interpretation of the two-way process principle (CBP 1) and its implementation through the financial support provided by the EIF. Based on examples given by ...
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Separation and Localisation of P300 Sources and Their Subcomponents Using Constrained Blind Source Separation
... The basic form of the constrained algorithm can be mod- ified to mitigate some inherent problems with this approach. Firstly, the present form of the algorithm tries to produce n outputs that are as close as possible to ...
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