p38 and JNK
Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways
... the P38 and JNK cascades, thus inhibiting inflammation and the release of inflammatory mediators, and alleviating apoptosis and autophagy as well, thereby reducing hepatocytes injury and liver enzymes ...
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Original Article Xanthotoxol inhibits cerebral ischemia/reperfusion injury-induced hippocampal neuronal cell apoptosis through suppressing the p38 MAPK and JNK signaling pathways
... of p38 MAPK changes in ischemic brain tissue and that inhibition of the p38 MAPK activation can provide protection in a variety of in vitro and in vivo models of brain injury by prevention of cell death ...
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Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen activated protein kinases in articular chondrocytes
... for p38 and JNK MAPK in iNOS activation was observed by Mendes and coworkers using IL-1β stimula- tion ...the p38 and p42/ 44 MAPK pathways have been reported to be involved in iNOS induction by ...
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Herpes Simplex Virus ICP27 Activation of Stress Kinases JNK and p38
... of p38 kinase activity by treatment of infected cells with the specific inhibitor SB203580 did not affect the viral transcription program ...of p38 and JNK in the virus life ...a p38-dependent ...
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Original Article Opposing role of JNK-p38 kinase and ERK1/2 in hydrogen peroxide-induced oxidative damage of human trophoblast-like JEG-3 cells
... ERK1/2, JNK and p38 kinase, were all activated under H 2 O 2 -induced oxidative ...of JNK and p38 kinase increased cell viability and decreased apoptosis induced by H 2 O 2 with their ...
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Original Article Electroacupuncture promotes locomotor recovery by inhibiting the activation of JNK and p38 MAPK signaling pathways in spinal cord injury rats
... of JNK and p38 MAPK, and apoptosis were detected using western blotting through measuring the levels of p-JNK, JNK, p-c-Jun, c-Jun, p-p38, p38 and activated caspase 3, ...of ...
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Portulacerebroside A inhibits adhesion, migration, and invasion of human leukemia HL60 cells and U937 cells through the regulation of p38/JNK signaling pathway
... of JNK and P38 protein level was measured by Western ...and P38 mitogen-activated protein kinase (P38) was decreased dra- matically in HL60 cells and U937 cells after PCA ...the ...
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Original Article Paeoniflorin inhibits PDGF-BB induced pulmonary arterial smooth muscle cells proliferation via p38 MAPK/JNK pathways and alleviate inflammation
... of p38 MAPK, ERK1/2, JNK, phospho-p38 MAPK (p-p38 MAPK), phospho-ERK1/2 (p-ERK1/2), and phospho-JNK ...of p38 MAPK and JNK, but not ...of p38 MAPK/JNK ...
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JNK and p38 Mitogen-Activated Protein Kinase Pathways Contribute to Porcine Circovirus Type 2 Infection
... of JNK/SAPK and p38 MAPK activation prevents PCV2-mediated caspase ...and p38 MAPK activation is required for PCV2-induced apoptosis, caspase-3 activity was assayed in the PCV2-infected PK15 cells at ...
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Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells
... in JNK, p38 and MAPK/ERK pathways were up ...while p38 and JNK phosphorylations were increased, ERK phosphorylations were decreased after using Quercetin + ...
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Original Article Sinomenine protects mice against ischemia reperfusion induced renal injury by attenuating inflammatory response and tubular cell apoptosis
... IR-induced p38 and ERK1/2 activation, and by which it provided protection for cardiomyocytes against IR-induced apoptosis ...suppressing JNK activity ...inhibited JNK, p38 and ERK1/2 ...
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LPS Induced Proliferation and Chemokine Secretion from BEAS 2B Cells
... MAP-Kinases p38 and JNK, tyrosine kinases, and PI3-kinase are involved in the signaling cascade from the LPS-CD14-complex on the cell surface to the increased cell proliferation and expression of IL-8; ...
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Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells
... MAPK p38 and JNK. Both the phosphorylations of MAPK p38 and JNK were increased following magno- lol treatment in a dose-responsive manner, whereas the dramatic decrease of phosphorylation was ...
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Varicella-Zoster Virus ORF12 Protein Triggers Phosphorylation of ERK1/2 and Inhibits Apoptosis
... (ERK1/2), p38, and c-Jun N-terminal kinase (JNK), results in stimulation of activator protein 1 (AP-1), which promotes gene ...ERK1/2, p38, and JNK to promote viral replication, but the ...
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Curcuminoid WZ35 synergize with cisplatin by inducing ROS production and inhibiting TrxR1 activity in gastric cancer cells
... growth was mediated through inhibiting TrxR1 activity. By inhibiting TrxR1 activity, WZ35 combined with cis- platin markedly induced the production of ROS, acti- vated p38 and JNK signaling pathways, and ...
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Attenuation of the macrophage inflammatory activity by TiO<sub>2</sub> nanotubes via inhibition of MAPK and NF-κB pathways
... (ie, p38, ERK1/2, and JNK) in both standard and LPS-stimulated culture conditions, by ELISA ...of p38 and ERK1/2 that peaks at 10 minutes and decreases for the 30 minutes incubation ...of JNK, ...
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MAPK/FoxA2-mediated cigarette smoke-induced squamous metaplasia of bronchial epithelial cells
... ERK1/2, p38 and JNK were mea- sured using an enzyme-linked immunosorbent assay (ELISA) reagent kit (ab119674; Abcam, Cambridge, UK) as described in the manufacturer’s ...
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Combination of Hypertension and High Fat and Cholesterol Diet Induces Severe Hepatic Inflammation in Rats via a Signaling Network Comprising NF- B, MAPK, and Nrf2 Pathways
... of p38 and JNK p54, which are involved with MAPK signaling, in the hypertensive SHRSP5/Dmcr strain compared with the normotensive WKY, thereby suggesting that the increased activation of TAK1-dependent MAPK ...
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Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis
... Extracellular-signal regulated kinase (ERK) activation by MEK plays a key role in many of the cellular processes that underlie progressive kidney fibrosis including cell proliferation, apoptosis and transforming growth ...
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Original Article 10% HA/SPEEK/PEEK composite promotes proliferation and differentiation of osteoblast cells through the MAPK and PI3K/AKT signaling pathways
... ERK, JNK, and P38 signaling pathways were activated by 10% HA/SPEEK/PEEK ...the P38 signaling pathway, HA also increases BMP-2 expression level to promote differentiation of periodontal ligament ...
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