p38 MAPK
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease
... of p38 MAPK in microglia, astrocytes, and neurons can all be induced through osmotic stress and the release of cytokines such as tumour-necrosis-factor- (TNF-) α and interleukin (IL) 1- α / β , which ...
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Original Article Impacts of SB203580 on the spatial memory and the expression of phosphorylated p38 MAPK and Homer1a in the hippocampus in rats with diffuse brain injury
... of p38 MAPK which mediates the nerve injury after ...of p38 MAPK, and p38 MAPK activation is indispensable in this ...of p38 MAPK pathway by SB203580 ...of ...
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The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
... the p38 MAPK pathway is required for normal skeletogenesis in mice, as mice with deletion of any of the MAPK pathway member–encoding genes MAPK kinase 3 (Mkk3), Mkk6, p38a, or p38b displayed ...
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Role of Regulatory Elements and the MAPK/ERK or p38 MAPK Pathways for Activation of Human Cytomegalovirus Gene Expression
... the MAPK/ERK pathway or the p38 MAPK pathway has an effect on the activation of the UL4- CAT promoter, we pretreated serum-starved HFFs with the kinase inhibitors for 1 h before ...inhibitor. ...
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Original Article Epinephrine increases malignancy of breast cancer through p38 MAPK signaling pathway in depressive disorders
... of p38 MAPK in cells and enhanced the growth of tumor in ...epinephrine-induced p38 MAPK signaling pathway enhances the malignancy of breast cancer in depressive ...
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Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors
... Mouse models with genetically or chemically- induced colon tumors have greatly enriched our knowledge of the basic biology of CRC but these models usually lack the complexity of the human tumors. Moreover, murine tumors ...
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Chondrocyte response to growth factors is modulated by p38 mitogen activated protein kinase inhibition
... which p38 MAPK inhibition restores prolif- eration in IL-1-activated/stressed human chondrocytes may thus be different from those described for lapine prepara- tions (current studies) or for bovine ...
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Effect of p38 Mitogen-Activated Protein Kinase on the Replication of Encephalomyocarditis Virus
... and MAPK inhibitors on the produc- tion of EMC progeny ...the p38 MAPK inhibitors SB203580 and SB202190, but not by the ERK inhibitor ...of MAPK inhibitors, because the ERK inhibitor did not ...
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Regulation of dematin by the p38 MAPK and the adaptor protein 14 3 3
... 114 phosphorylated. The number of sites detected varies with species and cell type, and so sites have to be validated on an individual basis. Detection of the same peptide can also be inconsistent. We have demonstrated ...
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Phosphorylation and Function of the Kaposin B Direct Repeats of Kaposi's Sarcoma-Associated Herpesvirus
... activator of p38 MAPK and MK2 (11, 16). Figure 2D shows that MK2 kinase activity was indeed augmented by expression of the kaposin B monomer. We conclude that oligomerization of the kaposin B direct repeats ...
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CD95 induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen activated protein kinase
... Activated p38 in turn phosphor- ylates transcriptional factors, thereby transducing signals into the nucleus to alter gene expression ...that p38 MAPK is essential for regulating hypertrophy and ...
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Hyperosmotic and thermal stresses activate p38 MAPK in the perfused amphibian heart
... Since any disturbance of intracellular and extracellular osmolarity is paralleled by alterations of cell volume (Lang et al., 1998), the role of the latter should be considered in order to elucidate the possible ...
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Tolfenamic Acid Inhibits the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma: Involvement of p38 Mediated Down Regulation of Slug
... the p38 MAPK and JNK ...of p38, and the inhibition of p38 with SB203580 reversed the cy- totoxic, anti-invasive, and anti-migratory effects of TA treat- ment in NPC cell ...of p38 also ...
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The role of the Grb2–p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis
... activate MAPK cascades via an interaction with the Ras guanine nucleotide exchange factor SOS and with other signaling ...and p38 MAPK in cardiac ...cardiac p38 MAPK and JNK activation ...
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Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen activated protein kinase signaling pathway
... the p38 MAPK has emerged as a key signaling molecule in the regulation of cancer invasion and metastasis by modulating the expression and activity of molecules governing the degradation of extracellular ...
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siRNA transfection in larvae of the barnacle Amphibalanus amphitrite
... The siRNA for A. amphitrite p38 MAPK (KC287236) spans nucleotides 472–490 and the target sequence is 5′-GACTGCGAGCTCAAGATCC-3′ (Hu et al., 2007). A BLAST search of the NCBI database confirmed this segment ...
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HoxA10 Facilitates SHP-1-Catalyzed Dephosphorylation of p38 MAPK/STAT3 To Repress Hepatitis B Virus Replication by a Feedback Regulatory Mechanism
... stimuli, p38 MAPK is activated by phosphorylation, enters the nucleus, and phosphorylates ...with p38 MAPK to repress the signaling ...facilitate p38 MAPK dephosphorylation, ...
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Extracellular pH changes activate the p38 MAPK signalling pathway in the amphibian heart
... the p38-MAPK activation. However, SB203580, the specific p38-MAPK inhibitor, did not affect the increase in HSP70 protein levels induced by alkalosis ...was p38-MAPK ...
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Hepatitis B Virus X Protein Activates the p38 Mitogen-Activated Protein Kinase Pathway in Dedifferentiated Hepatocytes
... the p38 MAPK enzyme by immunocomplex kinase assays of cellular extracts (3pX-1 and 4pX-1 cells) in a time course (6 to 24 h) following pX expression, using the phospho-active p38 kinase antibody and ...
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SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation
... phospho-p38 MAPK (Thr180/Tyr182), p38 MAPK (Cell Signaling); BLK, FGR, HCK, MYH, myogenin, NOTCH3, GAPDH (Santa Cruz Biotechnology); and ...
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