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p38 MAPK, apoptosis pathway

Evodiamine Induces Extrinsic Apoptosis Through P38
Mapk Pathway and Inhibits Autophagy in Gallbladder Cancer

Evodiamine Induces Extrinsic Apoptosis Through P38 Mapk Pathway and Inhibits Autophagy in Gallbladder Cancer

... increase apoptosis by augmentation of caspase-8 activity [33,34] In our research, the inhibition of autophagy caused by EVO may have the same effect on strengthening apoptosis with up-regulation of cleaved ...

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Original Article Emodin inhibits formation of hypertrophic scars through regulating the p38/MAPK signaling pathway

Original Article Emodin inhibits formation of hypertrophic scars through regulating the p38/MAPK signaling pathway

... induces apoptosis, and represses Col I, Col III, and α-SMA expression in in vitro and ex vivo in an HS ...attenuates p38 phosphorylation in a dose-dependent ...the p38/MAPK signaling ...

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Original Article Polydatin reduces IL-1β-induced chondrocytes apoptosis and inflammatory response via p38 MAPK signaling pathway in a rat model of osteoarthritis

Original Article Polydatin reduces IL-1β-induced chondrocytes apoptosis and inflammatory response via p38 MAPK signaling pathway in a rat model of osteoarthritis

... IL-1β-induced apoptosis and inflammatory response, Real-time PCR and Western blot analyses were performed to study changes in Bax, Bcl-2, MMP13 and p38 MAPK ...and p38 expression was measured ...

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Involvement of the p38 MAPK-NF-κB Signal Transduction Pathway and COX-2 in the Pathobiology of Meniscus Degeneration in Humans

Involvement of the p38 MAPK-NF-κB Signal Transduction Pathway and COX-2 in the Pathobiology of Meniscus Degeneration in Humans

... [ERK], p38) are well-conserved serine/threonine kinases that convert extracellular stimuli into specific cellular ...and apoptosis (30,31). The p38 MAPK signaling pathway is also ...

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Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells

Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells

... and p38-mediated apoptosis of cancer cells such as breast cancer [26], colon cancer [23] and lung cancer cells ...of MAPK members in anti-cancer drugs-induced apoptosis may depend on cell ...

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Differential profile of p38 mapk pathway in changeoxidative stress, nitric oxide production and celldeath in llc pk1 and mdck cells: case amphotericin b and cyclosporine

Differential profile of p38 mapk pathway in changeoxidative stress, nitric oxide production and celldeath in llc pk1 and mdck cells: case amphotericin b and cyclosporine

... the p38 MAPK signaling pathway is involved in a variety of cellular responses, including inflammation, cell cycle, cell death and cell differentiation, emphasis on p38 MAPK functions ...

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Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH 1) through p38 MAPK FOXO3a pathway

Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH 1) through p38 MAPK FOXO3a pathway

... p38 MAPK inhibitor SB203580 and NAC can alleviate resveratrol-induced apoptosis and ROS accumulation Next, cells were treated with the p38 MAPK inhibitor SB203580 to investigate whether ...

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p38 mitogen-activated protein kinase determines the susceptibility to cigarette smoke-induced emphysema in mice

p38 mitogen-activated protein kinase determines the susceptibility to cigarette smoke-induced emphysema in mice

... the p38 MAPK inhibitor suppressed smoke-induced changes leading to lung ...the p38 MAPK pathway regulates apoptosis, inflammation, and fibrosis, which are potentially associated ...

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Calcitonin gene-related peptide promotes proliferation and inhibits apoptosis in endothelial progenitor cells via inhibiting MAPK signaling

Calcitonin gene-related peptide promotes proliferation and inhibits apoptosis in endothelial progenitor cells via inhibiting MAPK signaling

... and apoptosis by MAPK signalling in other cell types [25 – 28, 31], although the pathways controlling apop- tosis activation and inhibition are ...inconsistent. p38 functions in an anti-apoptotic ...

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Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway

Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway

... induced apoptosis in a time-dependent and dose-dependent manner in CRC ...obvious apoptosis in tumors excised from mice receiving oral deguelin treatment compared to those from the control ...of p38 ...

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Original Article Resveratrol protects human renal proximal tubular cells from high glucose and hypoxia/ reoxygenation induced injury via inhibiting p38-MAPK and thioredoxin-interacting protein (TXNIP) pathways

Original Article Resveratrol protects human renal proximal tubular cells from high glucose and hypoxia/ reoxygenation induced injury via inhibiting p38-MAPK and thioredoxin-interacting protein (TXNIP) pathways

... of p38-MAPK pathway by SB203580 in cul- tured HK-2 cells could not only markedly reduced p38-MAPK activation, but also de- creased HH/R-induced TXNIP expression and oxidative stress ...

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CD95 induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen activated protein kinase

CD95 induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen activated protein kinase

... Activated p38 in turn phosphor- ylates transcriptional factors, thereby transducing signals into the nucleus to alter gene expression ...that p38 MAPK is essential for regulating hypertrophy and ...

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Murine Coronavirus Replication-Induced p38 Mitogen-Activated Protein Kinase Activation Promotes Interleukin-6 Production and Virus Replication in Cultured Cells

Murine Coronavirus Replication-Induced p38 Mitogen-Activated Protein Kinase Activation Promotes Interleukin-6 Production and Virus Replication in Cultured Cells

... with p38 activation in this cell line, Mnk1 phosphorylation occurred ...of p38 MAPK ...activated p38 MAPK, MHV- infected J774.1 cells were treated with the p38-specific inhibi- ...

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Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells

Plumbagin induces G<span style="font-size: 8.3333330154419px">2</span>/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells

... distribution, apoptosis, and autophagy, and the underlying mechanisms in the human TSCC cell line ...arrest, apoptosis, and autophagy in SCC25 ...induced apoptosis and autophagy in SCC25 ...and ...

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SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation

SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation

... Recent data implicated SFKs in the NOTCH pathway, showing that SFK inhibition decreased the active cleaved form of NOTCH1 in pancreatic cancer cells [16]. This is particularly intriguing because NOTCH signaling is ...

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Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes

Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes

... The underlying mechanism through which obesity contributes to the development of cardiac fibrosis in cardiovascular disease, however, remains poorly understood. Moreover, the mechanism through which leptin affects ...

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The role of the Grb2–p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis

The role of the Grb2–p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis

... activate MAPK cascades via an interaction with the Ras guanine nucleotide exchange factor SOS and with other signaling ...and p38 MAPK in cardiac ...cardiac p38 MAPK and JNK activation ...

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Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP

Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP

... (ERK) MAPk cascade, but not that of p38 MAPk. A specific p38 MAPk inhibitor (SK&F 86002) blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis ...

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Interactions between integrin αIIbβ3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans

Interactions between integrin αIIbβ3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans

... by MAPK inhibition (31), suggesting that activated MAPKs could play a role in the Pro33 regulation of ...of MAPK signaling in the enhancement of SERT activity by incubating SERT/Leu33 and SERT/Pro33 cells ...

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Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction

Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction

... in p38-MAPK phosphorylation along with NOS upregula- tion in kidney cortex and thoracic ...between p38-MAPK upregulation, ET-1 and NO mechanisms and development of renal and vas- cular ...

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