P450 genes
Pyrethroid Resistance in Malaysian Populations of Dengue Vector Aedes aegypti Is Mediated by CYP9 Family of Cytochrome P450 Genes
... the genes associated with metabolic resistance in these ...204 genes were commonly over-expressed with monooxygenase P450 genes (CYP9J27, CYP6CB1, CYP9J26 and CYP9M4) consis- tently the most ...
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Permethrin Induction of Multiple Cytochrome P450 Genes in Insecticide Resistant Mosquitoes, Culex quinquefasciatus
... chrome P450 CYP6D1 in house flies. Abass et al. [66] reported that some P450 genes (CYP3A4, CYP2B6 and CYP2A6) in HepaRG cells could be induced by pyre- throids through both PXR and CAR, and PXP is ...
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Sex specific induction of CYP6 cytochrome P450 genes in cadmium and lead tolerant Anopheles gambiae
... cytochrome p450 genes in ...cytochrome p450 gene ...cytochrome p450 gene, precipitating observed reduced expression of the ...cytochrome p450, and subsequently re- duced cadmium induced ...
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Steroid biotransformations in biphasic systems with Yarrowia lipolytica expressing human liver cytochrome P450 genes
... codon-optimized P450 2D6syn (A) or P450 3A4syn (B) in combination with the wild-type human or ...cytochrome P450 reductase (CPR) activity (determined as NADPH-cytochrome c reductase, NCR) ...
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Associations of Polymorphisms of the CYP1A1 and CYP1B1 Cytochrome P450 Genes with Breast Cancer in Kazakhstan
... In the Kazakh ethnic group no associations of geno- types distribution and allele frequency at rs1056836 site of CYP1B1 gene with BC were found. These findings are in agreement with the results of similar studies ...
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Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the Brown Planthopper
... Wild-type (CYP6ER1vL) and mutant CYP6ER1 variants were synthesized and provided in the pUASTattB40 plasmid (Geneart, CA, USA). Using the PhiC31 system, clones were transformed into the germline of a D. melanogaster ...
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Genome wide survey of cytochrome P450 genes in the salmon louse Lepeophtheirus salmonis (Krøyer, 1837)
... Compared to the number of CYP genes in free-living crustaceans, e.g. 75 in the phyllopod D. pulex [51] and 52 and 46 in the non-parasitic copepods T. japonicus and P. nana [49, 50], respectively, the L. salmonis ...
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Allelic variation and multigenic metabolic activity of cytochrome P450s confer insecticide resistance in field populations of anopheles funestus s.s., a major malaria vector in Africa
... coding genes of which 10 are P450s from CYP6 family and four of these genes (CYP6P9, CYP6P4, CYP6AA4 and CYP6P1) are overexpressed in pyrethroid resistant ...that P450 genes and their ...
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Bioluminescent Cytochrome P450 Assays
... Cytochrome P450 enzymes (P450s) are the major catalyst for the oxidative metabolism of a vast array of hydrophobic chemicals including therapeutic drugs ...because P450 inhibition can alter drug disposition ...
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Molecular basis of permethrin and DDT resistance in an Anopheles funestus population from Benin
... these P450 genes were highly upregulated in pyrethroid- resistant laboratory and field population from southern Africa [9, 15, 16, 31, 46, 47] while a lower level of over- expression was recorded in ...
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Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector
... cytochrome P450 genes is the most important driver of pyrethroid resistance in the major African malaria vector Anopheles funestus and detected key mutations controlling this ...duplicated genes ...
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Restriction to gene flow is associated with changes in the molecular basis of pyrethroid resistance in the malaria vector Anopheles funestus
... cytochrome P450 genes was the main mechanism driving this ...up-regulated genes included CYP6P9a, CYP6P9b and ...these genes was detected across a south/north transect with CYP6P9a and CYP6P9b ...
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Characterization of diverse natural variants of CYP102A1 found within a species of Bacillus megaterium
... into P450 diversity in bacteria. Extensive diversity of P450 genes has been found in bacteria, including a large set of strains of the genus Bacillus (Porwal et ...bacterial P450 enzymes ...
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Gene Expression Profiling Reveals That PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice
... cytochrome p450 genes and corresponding nuclear receptors in mouse liver. Pregnane X 485[r] ...
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Molecular cloning and expression of a vernalisation-induced cytochrome P450 gene from Arabidopsis thaliana
... Consequently, the aims of my project were: 1 to isolate cDNA clones encoding KAH and the other Cyt P450 genes involved in the early GA biosynthetic pathway between Kaurene and GA12, 2 to[r] ...
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Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production
... cDNA and placed under the control of A. oryzae promoters (Fig. 3A). Twelve independent transformants were screened for their ability to inhibit B. subtilis growth via plate-based bioassay. Eleven strains showed ...
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Identification of reliable reference genes for quantitative real-time PCR normalization in pitaya
... Pitaya or pitahaya, also known as dragon fruit, origi- nated from rainforest in tropical and subtropical areas of Central America and Mexico. Pitaya belongs to the genus Hylocereus in the Cactaceae family. Currently, ...
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Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver
... Cyp2a4 gene is highly related to Cyp2a5 (>98% identity in the amino acid sequences of their coding region) and both are expressed in the mouse liver. Despite their high degree of similarity, Cyp2a4 and Cyp2a5 ...
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Liver-Metabolizing Genes and Their Relationship to the Performance of Elite Spanish Male Endurance Athletes; a Prospective Transversal Study
... candidate genes year by year ...metabolizing genes, referring to their help in the sys- temic detoxification of drugs and potentially harmful chemicals and cancer inducers ...
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Microarray and RNAi Analysis of P450s in Anopheles gambiae Male and Female Steroidogenic Tissues: CYP307A1 Is Required for Ecdysteroid Synthesis.
... encoding CYP307A1 has been first described in the Drosophila Halloween mutants [13] and further identified in a differential display PCR screen in the PG of the Lepidoptera Bombyx mori [18]. In D. melanogaster, unlike ...
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