p47-phox
A p47 phox pseudogene carries the most common mutation causing p47 phox deficient chronic granulomatous disease
... the p47-phox gene revealed a considerable number of discrepancies between different cDNA clones and an apparently high number of polymor- phisms (17, 18, 32, ...for p47-phox re- vealed (based ...
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In vitro molecular reconstitution of the respiratory burst in B lymphoblasts from p47 phox deficient chronic granulomatous disease
... Both p47-phox and p67-phox were detected by immunoblot in the cytosol of control and parent cell lines and, as in neutrophils, these proteins had affinity for ...detectable p47-phox by ...
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Virulence of catalase deficient aspergillus nidulans in p47(phox) / mice Implications for fungal pathogenicity and host defense in chronic granulomatous disease
... Chronic granulomatous disease (CGD) is a rare genetic dis- order in which phagocytes fail to produce superoxide be- cause of defects in one of several components of the NADPH oxidase complex. As a result, patients ...
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A point mutation in gp91 phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47 phox and p67 phox
... components: p47-phox and p67-phox, residing in the cytosol of resting phagocytes, and gp91-phox and p22-phox, constituting the membrane-bound cytochrome ...proteins ...
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Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly Translocation of p47 phox and p67 phox requires interaction between p47 phox and cytochrome b558
... oxidase), p47-phox, and ...neither p47-phox nor p67-phox translocated to the membrane in PMA-stimulated CGD neutrophils which lack cytochrome ...with p47-phox deficiency, ...
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Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phoxsubunit of NADPH oxidase
... gp91 phox in WT neutrophils was determined by comparing it with that of gp91 phox-/- ...gp91 phox sig- nificantly decreased naloxone binding to neutrophils in both whole cell and cell membranes ...
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NADPH oxidase 2-derived reactive oxygen species signal contributes to bradykinin-induced matrix metalloproteinase-9 expression and cell migration in brain astrocytes
... Moreover, Nox is considered to be a major source of ROS in several physiological and pathological processes [8,24]. To date, there are five isoforms of Nox have been discovered, including Nox1-5 [24]. Nox1, Nox2, and ...
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Identification of a thermolabile component of the human neutrophil NADPH oxidase A model for chronic granulomatous disease caused by deficiency of the p67 phox cytosolic component
... either p47- phox or p67-phox suggested that the defective component of heat-inactivated cytosol was ...not p47-phox, exhibited lability at 46 degrees C and completely reconstituted ...
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Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells
... of p47 phox , p67 phox , and p40 phox ...of p47 phox leads to a conformational change allowing its interaction with p22 phox ...that p47 phox organizes the ...
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Sepsis-induced selective parvalbumin interneuron phenotype loss and cognitive impairments may be mediated by NADPH oxidase 2 activation in mice
... (gp91 phox and p22 phox ) and four cytoplasmic subunits (p40 phox , p47 phox , p67 phox , and the small G-protein Rac) [27, ...
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NADPH oxidase-mediated redox signal contributes to lipoteichoic acid-induced MMP-9 upregulation in brain astrocytes
... or p47 phox inhibitor apocynin (Apo, 10 μM) significantly attenuated the LTA-induced MMP-9 pro- tein and mRNA expression in RBA-1 ...stimulates p47 phox -mediated Nox activity, as shown in ...
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Colitis susceptibility in p47phox−/− mice is mediated by the microbiome
... in p47 phox−/− mice using DSS ...in p47 phox−/− ...bred p47 phox−/− and B6Tac mice have distinct microbiome signatures, which can be normalized by co- housing or heterozygous ...
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Regulation of Fungal Infection by a Combination of Amphotericin B and Peptide 2, a Lactoferrin Peptide That Activates Neutrophils
... The accurate mechanism is unclear, but the decrease in neutrophil function obtained with 50 g of peptide 2/ml was consistent with the decreased levels of expression of p47 phox and p67[r] ...
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The p67 phox cytosolic peptide of the respiratory burst oxidase from human neutrophils Functional aspects
... described in which the failure of O2- production was associated with the absence of a 67-kD polypeptide (p67-phox) from the cytosol of affected neutrophils. Using neutrophils obtained from a patient with this form ...
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Aldosterone Induces Oxidative Stress Via NADPH Oxidase and Downregulates the Endothelial NO Synthesase in Human Endothelial Cells
... (Nox2, p47 phox and p22 phox protein levels), and these alterations were significantly abolished on pre-incubation with the MR antagonist, ...
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Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
... anti-p47 phox antibody was obtained from Upstate (Lake Placid, ...gp91 phox antibody was purchased from BD Transduction Laboratories (San Jose, ...
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Nicorandil prevents endothelial dysfunction due to antioxidative effects via normalisation of NADPH oxidase and nitric oxide synthase in streptozotocin diabetic rats
... subunit p47 phox was increased in femoral artery (Figure 3A) as well as apocynin significantly decreased high glucose-induced ROS production in HCAECs (Fig- ure 4H), indicating that the endothelial ...
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Eighteen baculovirus genes, including lef-11, p35, 39K, and p47, support late gene expression.
... of p47, 39K, and a gene upstream of 39K in late gene ...genes, p47, an ORF encoding a predicted 43-kDa protein (5), and 39K (13) are shown as arrows below the ...(pETL7/SB, p47, and pPstI-K) are ...
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Land-use influences phosphatase gene microdiversity in soils
... and PhoX (Cosgrove, 1980) which also acts upon other phosphate ...however phoX is less widely distributed but more abundant in terrestrial settings than marine (Ragot et ...
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Characterization of the adaptor-related protein complex, AP-3.
... uitously expressed isoform of b -NAP to form complexes with p47A. Using a heterologous in vitro system we showed that the p47/ b -NAP complex can be recruited from brain cytosol onto membranes prepared from tissue ...
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