p53 mutant
Quaternary structure of the specific p53 DNA complex reveals the mechanism of p53 mutant dominance
... bound p53 particles, we used a DNA target with several contiguous p53 binding ...consecutive p53 CON REs (Figure ...revealed p53–DNA complexes with 3–4 protein particles attached to DNA ...
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HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status
... of mutant p53 [34], and SAHA inhibited cell growth in mutant p53 human cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-HSP90 chaperone axis ...containing ...
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SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B
... in p53 mutant astro- cytoma cells led to G1 phase ...a p53 null cell line-induced G1 phase arrest ...that p53 status is crit- ical for the regulation of the cell cycle by ...
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Modulation of MDR/MRP by wild type and mutant p53
... wild-type p53 activity and acquisition of a multidrug resistance (MDR) phenotype, two apparently key factors in the resistance of human can- cers to chemotherapy, may be interre- ...Wild-type p53 represses ...
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Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
... how p53 is down-regulated after cell ...to p53 disruption in tumourigenesis. Enforced differentiation in p53 mutant cancer may become a powerful therapeutic tool in cancer chemotherapy and ...
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ERβ decreases the invasiveness of triple-negative breast cancer cells by regulating mutant p53 oncogenic function
... on mutant p53 signaling since p53 is frequently mutated in TNBC and mutant p53 proteins promote tumor metastasis [10, 12, 17, ...of mutant p53 gain-of-function the ...
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Functional p53 Signaling in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas: Implications for Therapy
... intact p53 signaling as well as elevated levels of Hdm2 contribute to the marked sensitivity of PEL to ...of p53 tar- get genes in response to Nutlin-3 treatment is tumor type dependent (16, 41, 60, ...the ...
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Adenovirus E1B 55-Kilodalton Protein Is a p53-SUMO1 E3 Ligase That Represses p53 and Stimulates Its Nuclear Export through Interactions with Promyelocytic Leukemia Nuclear Bodies
... a mutant form of p53 unable to form tetramers and therefore to gener- ate a network such as that diagrammed in ...WT p53, as measured by FRAP (Fig. 7e). However, this p53 mutation would not be ...
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DNA-Mediated Oxidation of Transcription Factor p53
... within p53, N239Y has been observed in colorectal cancer somatic cell ...C277-p53′ mutant binds Gadd45 DNA with comparable affinity as p53′ but does not to dissociate as readily at 22% and not ...
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Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo
... of 5 to 10 mM 2-DG plus 0.5 mM phenformin (Figure 2B and 2C). Morphological cell death was obvious after 24 hours of treatment (representative microscopic pictures are shown in Figure 2D). In a wound healing assay to ...
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GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner
... and p53 with different mutational status. GTSE1 regu- lates p53 function to promote breast cancer progression mainly by the following three ...type p53 was restrained by oncogene GTSE1 via ...
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p53 Expression in Triple Negative Breast Carcinomas: Evidence of Age Related and Racial Differences
... their p53 status and this “p53 signature” predicts mutation status and patient survival in different patient subsets inde- pendent of other risk factors ...and p53 in mam- mary stem cell progenitors ...
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... of p53 protein tended to be ...the mutant p53 expression in N cell culture will not show any significant increase or de- crease, so that the results of data analysis mutant p53 ...
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CP 31398 restores mutant p53 tumor suppressor function and inhibits UVB induced skin carcinogenesis in mice
... of p53 target, cell- cycle regulatory, and apoptosis-related proteins in the skin of mice chronically irradiated with ...of p53 and its downstream target gene p21 CIP1 in UVB-irradiated skin of ...
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Functional repair of p53 mutation in colorectal cancer cells using trans-splicing
... Available p53-based gene therapy as a therapeutic strategy contains the administration of wt-p53 or the suppression of mutant p53 expression in p53-defective cancer ...of ...
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Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.
... To determine whether p53 can influence the growth of normal human genital epithelial cells, wild-type and mutant p53 genes were cotransfected with the neomycin resistance gene into early[r] ...
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Role of spirulina platensis on mitomycin c induced genotoxicity in ehrlich ascites carcinoma bearing albino mice: single cell gel electrophoresis (comet assay) and semiquantitative rt pcr analysis
... Bcl-2, P53, and P21 expression in the hepatic cells at the dose of 1% of the rat diet and also the results were in agreement with (Ismail et ...of P53 mRNA in liver of doxorubicin treated ...
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Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene
... This suggested that the interaction be- tween mdm-2 and mutant p53 may be similar to the interaction between mdm-2 and wild-type p53 (i.e., mdm-2 in binding to the N-terminal transactiva[r] ...
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The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism
... the p53 gene that abrogate its DNA binding and transactivation activity ...that mutant p53 gain-of-function activity is dependent on its de novo ability to activate gene expression [23, ...that ...
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Targeting p53 by small molecules in hematological malignancies
... type p53-dependent apoptosis of Hodgkin’s lymphoma (HL) [67,68], mantle cell lymphoma (MCL) [69-72], ALK-positive anaplastic large cell lymphoma (ALCL) [73], B-cell lymphoma (BCL) [74,75], Burkitt’s and follicular ...
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