P53 status
p53 status correlates with the risk of progression in stage T1 bladder cancer: a meta analysis
... The main outcome measures for this meta-analysis were rates of progression. The primary aim was to search the effect of p53 status (positive or negative) detected by IHC on progression rates. For ...
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Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells
... the p53 status and the susceptibility to dl1520 infec- ...normal p53 function but not cells (primary cells and tumor cells) with normal p53 function ...some p53-positive tumor cells are ...
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Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
... the p53 status on the extrinsic apoptosis cascade activated by death inducing ligands like TRAIL is much more ...of p53 on extrin- sic apoptosis induction and the distribution of the three phenotypes ...
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MRI Texture Analysis Predicts p53 Status in Head and Neck Squamous Cell Carcinoma
... Image analysis has the potential to be complementary to tissue biopsy. On the one hand, tissue biopsy followed by immunohis- tochemistry analysis provides extensive genetic information, but only for a single anatomic ...
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Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status.
... Head and neck squamous cell carcinoma (HNSCC) is a significant cause of cancer deaths. Cisplatin-based chemoradiotherapy is a standard of care for locally advanced disease. ATR and DNA-PK inhibition (DNA-PKi) are ...
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Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors
... Here, we re-analyzed mRNA array profiling data obtained for > 100 primary NB to search for cell- cycle regulated genes correlating with patient outcome and MYCN status. Among these candidate genes, we ...
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The p53 status can influence the role of Sam68 in tumorigenesis
... Total genomic DNA was extracted from mouse earpiece using AccuStart II Mouse Genotyping Kit (Quanta) following the manufacturer’s protocol. Genomic PCR was performed with the following primers: Sam68 (forward 1) 5ʹ- GAT ...
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Tumor Suppressor Gene p53 status in Upper Gastro Intestinal Malignancies
... mutant p53 expression in the tissue studied from the endemic Hebei ...of p53 protein and over- expression of p21, telomerase and cyclin D proteins were early molecular events during the development of ...
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Original Article Prognostic value of p53 alterations in human osteosarcoma: a meta analysis
... surgery. p53 status was shown as p53 gene/protein expres- sion in 13 studies, while remaining 4 studies only showed p53 mutation [13, 16, 18, ...26]. p53 gene/protein expression was ...
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Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells
... the p53 status be- tween MDA-MB-231 and MDA-MB-157 cells, as well as potential defects in the phosphorylation events stabilising microtubule-associated proteins in a manner involving CYP2E1-mediated ROS, ...
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MDM2 and CDK4 amplifications are rare events in salivary duct carcinomas
... downregulation of wildtype p53 protein. In contrast, in tumors harboring particular TP53 mutations and retaining their wildtype TP53 allele, MDM2 amplification might contribute to oncogenesis by additionally ...
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Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor
... on p53-status. In control cells that express p53, IGF-1R inhibition reduced p53-dependent senescence in response to CP but increased p53-dependent ...in p53 knockdown cells and ...
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Integrating mechanisms of response and resistance against the tubulin binding agent Eribulin in preclinical models of osteosarcoma
... different p53 status and metastatic properties and the PPTP osteosarcoma xenograft tumor panel to study effects of eribulin on microtubule structure, mitotic cell cycle blockade, mitochondria activity and ...
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Original Article Overexpression of enhancer of zeste homolog 2 (EZH2) and focal adhesion kinase (FAK) is associated with cancer metastasis and poor prognosis in breast cancer
... (ER status: hazard ratio (HR) = ...PR status: HR = 0.790, 95% CI: 0.338-1.061; AR status: HR = ...EZH2 status: HR = 1.376, 95% CI: 0.845-2.242; FAK status: HR = ...EGFR status, ...
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SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B
... in p53 mutant astro- cytoma cells led to G1 phase ...a p53 null cell line-induced G1 phase arrest ...that p53 status is crit- ical for the regulation of the cell cycle by ...
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Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy
... Despite the promising results we obtained from this study, there were some limitations. First, the antineoplastic potential of pramlintide was tested only using the short-term MTT assay. Second, we utilized only two ...
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Determination of p53 role in cancer biology and therapy through interactome development and analysis
... Comparing differential expression profiles of apoptotic and angiogenic factors in silico to ‘omics’ p53 wild type and null profiles has derived several important predictions of therapeutic relevance. For example, ...
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Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients
... 1. P53 protein expression data were available for two of the four studies (Table ...anti-human p53-antibody (DO-7, DAKO) (Table 1). Missing p53 data could be attributed to missing tumor blocks, loss ...
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Mathematical modelling of the core regulatory feedback mechanisms of p53 protein that decide cell fate
... on p53 basal dynamics with one or two spontaneous pulses were reported in 2010 (Loewer et ...for p53 basal dynamics incorporating stochasticities in DNA damage and repair processes, and stochastic delay ...
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The double benefit of Spalax p53: surviving underground hypoxia while defying lung cancer cells in vitro via autophagy and caspase-dependent cell death
... the p53- null human non small cell lung cancer model (H1299), a valuable platform for researching p53-related ...Spalax p53 plasmids were transiently transfected into the ...type p53 plasmid ...
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