P53 tumor suppressor gene
Investigation of solvent effect and NMR shielding tensors of p53 tumor-suppressor gene in drug design
... The p53 tumor-suppressor gene encodes a nuclear phosphoprotein with cancer- inhibiting ...this suppressor function through various mechanisms including gene deletions and point ...
6
Solvent effects on structural and thermochemical properties of p53 tumor-suppressor gene: a molecular modeling approach in drug design
... The p53 tumor-suppressor protein is a cellular phosphoprotein and a negative regu- lator of cell ...Most p53 mutations occur in exons 5–8 within the DNA-binding ...Therefore, p53 can ...
7
Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages
... The p53 tumor suppressor gene plays an important role in protecting cells against DNA damage and strand breaks [14], and the im- pact of UVB on p53 has been experimentally verified ...
7
EXPRESSION OF TUMOR SUPPRESSOR GENE P53 CORRELATION WITH GASTRIC ADENOCARCINOMA PATIENTS BY USING IMMUNOHISTOCHEMICAL ASSAY
... protein monoclonal antibody. Our studied patients mean age 59 years, ranged between (30- 70) years, 26 patients aged over 50 years, and the other 17 patients were falling under 50 years, male: female ratio was 2 : 1, ...
8
Chondrosarcoma of the spine: A rare case with unusual presentation
... c-met gene which encodes for a transmembrane tyrosine kinase has been shown to be associated with the development of cartilag- inous tumors ...the tumor suppressor genes, several studies have shown ...
5
5-Fluorouracil-induced RNA stress engages a TRAIL-DISC- dependent apoptosis axis facilitated by p53
... sensitive tumor cell ...the p53 tumor suppressor plays a central role in DNA damage responses, including DNA repair, the cell cycle regulations and apoptosis, a key focus has been on how these ...
19
The association of apoptotic protein expressions sensitive to apoptosis gene, p73 and p53 with the prognosis of cervical carcinoma
... apoptosis gene [SAG]), mitochondrial apoptotic proteins (B-cell lymphoma-extra-large [Bcl-xL] and Bcl-2 homologous antagonist/killer [Bak]), and tumor suppressor proteins (p73 and p53) were ...
8
Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors
... Pten tumor suppressor gene in the thyroid follicular cells exhibit constitutive PI3K pathway activation and develop, from birth, hyperplastic glands that progress to nodular lesions by 6-10 months of ...
18
Immunohistochemical Evaluation of Human p53 Tumor Suppressor Protein Content in Ductal Carcinoma in Situ of the Breast
... the p53 gene are present in 27-54% of primary invasive breast carcinomas ...of p53 expression in ductal carcinoma in situ (DCIS) have been limited ...
6
Inhibition of p53 Tumor Suppressor by Viral Interferon Regulatory Factor
... human tumor virus, is associated with the pathogenesis of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease (5, 6, ...and tumor induction in nude mice (13, 26). Thus, the K9 ...
11
Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor
... mutated gene in human cancer ...stress, p53 acts as a sequence-specific transcription factor and orchestrates the appropriate cellular response by inducing cell-cycle arrest, apoptosis, senescence, or ...
10
P53 Alteration Studies and Tumor Suppressor Gene in Human Bladder Cancer of Subjects Exposed to High Levels of Chlordane
... protein p53 which is present in the bladder cancer subjects do have it active domain to perform its anticarcinigenic functions in its body or ...on p53 concentrates on gene sequencing studies but ...
18
Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73
... of p53 and p73 binding sites within promoter-proximal regions, we have found that approximately 50% of the p53-associated promoters con- tain a p53 consensus site [30], whereas only 20% of the ...
16
Original Article Regulation of exogenous P53 combined with Dickkopf-1 on human osteosarcoma MG-63 cells
... exogenous P53 gene and Dickkopf-1 and to explore its possible mechanisms in order to provide the refer- ence for clinical treatment of ...exogenous P53 and Dickkopf-1 were used separately or jointly ...
7
CTS1: a p53 derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties
... and p53 constitute major suscepti- bility genes (35 and 50% of human cancers, respectively) (1, ...2). Gene therapy has been considered for these two types of genetic defects, but, despite ongoing clinical ...
9
Tumor Suppressor Gene p53 (mt) Expression in Mancozeb treated Mouse Liver
... The tumor suppressor gene p53 is located, on the short arm of chromosome ...These gene codes for anti- proliferation signals and proteins (p53), this protein composed of 393 ...
5
Cellular Reproduction
... When tumor suppressor genes don't work properly, cells can grow out of control. – More than 50% of tumors contain a mutation in the tumor suppressor gene p53..[r] ...
23
Loss of Heterozygosity at the Ink4a/ArfLocus Facilitates Abelson Virus Transformation of Pre-B Cells
... Mdm2 gene which maps about 6 cM distal to Xmv31 (data not ...a tumor suppressor already known to play an important role in the Ab-MLV transformation process ...wild-type p53 have very low to ...
9
Transcriptome-wide characterization of the endogenous miR- 34A-p53 tumor suppressor network
... target gene [12] - is down-regulated in response to miR-34A mimic transfection to a similar extent in TP53 mutant lines and TP53 wild-type lines (TP53 mutant: log 10 fold-change = ...
12
Tumor Suppressor Gene p53 status in Upper Gastro Intestinal Malignancies
... the p53 protein is kept at low concentration by its relatively short half life of about 20 ...of p53 in the cell and activation of p53 as a transcription factor (11, ...activated p53 acts to ...
77