PAI-2: Plasminogen activator inhibitor 2
Interaction between plasminogen activator inhibitor type 1 (PAI 1) bound to fibrin and either tissue type plasminogen activator (t PA) or urokinase type plasminogen activator (u PA) Binding of t PA/PAI 1 complexes to fibrin mediated by both the finger and the kringle 2 domain of t PA
... urokinase-type plasminogen activator ...by plasminogen activator inhibitor type 1 (PAI-1) that is either present in plasma or bound to fibrin, present in a ...by PAI-1 ...
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Genetic and Metabolic Determinants of Plasminogen Activator Inhibitor 1 (PAI 1) in Tunisian Type 2 Diabetes Patients
... [28] Saidi, S., Slamia, L.B., Mahjoub, T., Ammou, S.B. and Almawi, W.Y. (2007) Associ- ation of PAI-1 4G/5G and -844G/A Gene Polymorphism and Changes in PAI-1/tPA Levels in Stroke: A Case-Control Study. ...
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Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects
... increased PAI-1 concentration by 2 fold ...addition, PAI-1 may predict T2D independent of insulin resis- tance and other known risk factors for diabetes, which may be due to increase in PAI-1 ...
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Picornavirus Receptor Down-Regulation by Plasminogen Activator Inhibitor Type 2
... whether PAI-2- induced picornavirus receptor down-regulation was mediated by transcriptional or posttranscriptional activity, mRNA levels for ICAM-1, DAF, and PVR were examined in ...
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Plasminogen activator inhibitor-1 gene polymorphism as a risk factor for vascular complications in type 2 diabetes mellitus
... the PAI-1 4G/5G genotype had the highest prevalence of smoking, high BMI, high SBP and DBP, dyslipidemia, FBS, 2Hrs PBS, HbA1c %, total cholesterol, and ...and PAI-1 were found in patients with the 4G/5G ...
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Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin
... and PAI-1 regulate adhesion and migration of cells independently of, though influenced by, urokinase, implies an intrinsic duality of the uPA/plasmin sys- ...in plasminogen-defi- cient mice (2), in ...
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Successful treatment for disseminated intravascular coagulation (DIC) corresponding to phenotype changes in a heat stroke patient
... [1, 2], leading to dis- seminated intravascular coagulation (DIC) with a grave outcome ...the PAI-1 ...of plasminogen activator inhibitor-1 (PAI-1) that occurred in the later ...
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Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments
... of PAI-1 −/− mice showed the presence of six symptoms out of a list of seven in our behavioral screening system: anhedo- nia, apathy, weight loss, impairment in motivation/effort, self-centered behaviors deficit ...
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High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study
... tissue plasminogen activator (tPA) or high activity of its inhibitor (PAI-1), as independent risk factors for CVD is unclear, as these variables seem to mirror most compo- nents of the insulin ...
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Targeted expression of plasminogen activator inhibitor(PAI)-1 to the stomach inhibits gut-brain signalling by the satiety hormone cholecystokinin (CCK)
... The receptors (CCK-1 and CCK-2) at which CCK exerts its effects are both GPCRs, that when bound result in the activation of phospholipase C followed by an intracellular increase in Ca 2+ (Wank, 1995). It ...
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A suppressive effect of prostaglandin E<sub>2</sub> on the expression of <em>SERPINE1</em>/plasminogen activator inhibitor-1 in human articular chondrocytes: An <em>in vitro</em> pilot study
... PGE 2 suppressed the expression of SERPINE1/plasminogen activator inhibitor (PAI)-1 mRNA in chondrocytes, we focused on the effect of PGE 2 on PAI-1 in a panel of cultured ...
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Original Article Changes in spontaneous thrombolytic activity during progression of atherosclerosis in Apo and LDLR double knockout mice
... plasma PAI-1 concentration between the control and DKO groups. The plasma PAI-1 level at 14 weeks did not differ between ...plasma PAI-1 level at 22 weeks was significantly higher in DKO mice than ...
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"Hypoxia induced down regulation of microRNA 449a/b impairs control over targeted SERPINE1 (PAI 1) mRNA a mechanism involved in SERPINE1 (PAI 1) overexpression"
... the plasminogen activator urokinase-type (uPA) and -tissue-type (tPA) which mediate proteolysis of ECM components but also activation of latent, inactive MMPs ...protease inhibitor (serpin) protein ...
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Early changes in inflammatory and pro thrombotic biomarkers in patients initiating antiretroviral therapy with abacavir or tenofovir
... In the SMART study, two inflammatory biomarkers, high sensitivity C-reactive protein (hsCRP) and interleu- kin (IL)-6, were found to be higher among patients who were receiving abacavir than in those using other ...
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Engineering of serpins for vascular application
... serpins are capable of inhibiting thrombin: antithrombin (AT), heparin cofactor II (HCII), protease nexin-1 (PN-1), plasminogen activator inhibitor (PAI-1), and protein C inhibitor (PC[r] ...
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Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty
... with PAI-1 deficiency [28]. Important role of PAI-1 and vitronectin was also indicated in the vascular injury-associated occlu- sive thrombosis by regulating endogenous fibrinolysis ...between PAI-1 ...
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The neuroendocrine-like phenotype of gastric myofibroblasts and its significance in cancer.
... v/v 2-mercaptoethanol, 10% v/v glycerol, Bromophenol Blue) and heated for 4 min at 100 0 C (except for the media treated with StrataClean™ ...dH 2 O, 50ml 10xTBS, 500µl ...
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The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo
... and plasminogen activator inhibitor-1 (PAI-1), which are directly regulated by HIF-1 and are involved in the pathogenesis of kidney diseases, displayed significantly increased levels following ...
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Coagulation and anticoagulation in idiopathic pulmonary fibrosis
... from plasminogen in response to plasminogen activator, is a broad spectrum protease that is important in fibrinolysis but is also capable of degrading other extracellular proteins that leak into the ...
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Common TNF α, IL 1β, PAI 1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis
... pressure, temperature, lymphocyte count, platelet count, bilirubin and lactate dehydrogenase was not associated with in-hospital mortality. Variables were then grouped in two categories due to the many covariates ...
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