Pancreatic beta cell mass
Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass
... Besides an increased b-cell mass during the adaptation to insulin resistance, the most immediate response is the optimisation of the insulin secretion. The data from this study showed that ...
17
Re expression of IGF II is important for beta cell regeneration in adult mice
... enhance beta cell numbers or even to mitigate against the consequences of beta cell ...during beta cell regeneration in vivo has received limited attention to ...which ...
9
Pancreatic Beta Cell Plasticity and Involvement of Insulin- Expressing Progenitor Cells
... coincides with the developmental shift to larger islets and fewer β-cell aggregates as demonstrated here. We propose that in addition to the hormonal demands and somatic growth necessary at this age (26), ...
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Effect of protein glycation by methylglyoxal on pancreatic beta cell function
... on beta cells and involvement in early stage dysfunction and development of type 2 diabetes mellitus are not ...on beta cell function and related involvement in the development of ...of beta ...
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Bcl-2-functionalized ultrasmall superparamagnetic iron oxide nanoparticles coated with amphiphilic polymer enhance the labeling efficiency of islets for detection by magnetic resonance imaging
... transplanted pancreatic beta cells or islets have become a major ...of beta cells before transplantation could be a valuable pathway for moni- toring the islet transplant mass and function in ...
14
Impaired pancreatic beta cell function in the fetal GK rat Impact of diabetic inheritance
... b cell mass has been investigated in the this study by performing crossing ex- periments between diabetic GK and normoglycemic W ...their pancreatic insulin content and b cell mass, ...
7
glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
... β cell mass. In arxaMO-injected islets, we expect that α cell progenitors are diverted to δ and β cell identities, as in the mouse Arx knockout, where increases of 200% and 31%, respectively, ...
11
Transplanted beta cell response to increased metabolic demand Changes in beta cell replication and mass
... transplanted beta cells to modify their replication and mass when stimulated by changes in metabolic ...transplanted beta cells increased in Tx-Px ...normal pancreatic beta cells (0.38 ...
7
Stem cell approaches for diabetes: towards beta cell replacement
... the pancreatic duct epithelium could be stimulated therapeutically to make new islets ...after pancreatic injury ...the beta cell mass and reversal of ...from beta cell ...
9
Increasing beta cell mass to treat diabetes mellitus
... human pancreatic beta cells is an incredibly small basal proliferation index ...of pancreatic beta cells are ...quiescent beta cells is reduced to ...human beta cells exhibit ...
7
Detailed transcriptome atlas of the pancreatic beta cell
... the pancreatic islet ...β cell-specific genes such as PDX1, NEUROD1, IAPP, TCF1, NKX6-1 and ICA- 512 [see Additional File ...β cell death takes place during T1D and to a certain extent in T2D, ...
11
Advancement in Therapeutic Efforts and Tools for Prevention and Treatment of Insulin Dependent Diabetes Mellitis
... of beta cell mass, non -endocrine cell production, antigen-based therapy, pancreatic transplantation, use of immunosuppressive monocyte and control of IDDM by using naturally found CD4 ...
11
Antidiabetic effects of Eucalyptus globulus on pancreatic islets: a stereological study
... in pancreatic islet mass was probably due to an in- crease in the mass of its cells, especially beta cells, because they are the predominant cell type in the islet, and changes in their ...
7
A simple matter of life and death : the trials of postnatal beta cell mass regulation
... cited. Pancreatic beta-cells, which secrete the hormone insulin, are the key arbiters of glucose ...Defective beta-cell numbers and/or function underlie essentially all major forms of diabetes ...
21
Evaluation of serum c-peptide levels in type 2 diabetics in Punjabi population
... and pancreatic beta cell function than insulin measurements, this study suggests routine c-peptide testing in patients with poor glycaemic control so that treatment modality can be modified based on ...
5
2D QSAR ANALYSIS OF PHTHALIMIDE DERIVATIVES AS POTENT HYPOGLYCEMIC AGENTS
... in pancreatic beta cells), because they stimulate the release of insulin from the pancreatic beta cells through a different binding site on the “sulfonylurea receptor” ...
7
The transcription factors Nkx6 1 and Nkx6 2 possess equivalent activities in promoting beta cell fate specification in Pdx1+ pancreatic progenitor cells
... insulin-producing pancreatic beta-cells from stem cells is by recapitulating embryonic beta-cell differentiation (D’Amour et ...functional beta-cells for transplantation, however, will ...
10
Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
... the pancreatic b cell after pro- longed exposure to elevated concentrations of FFA has been previously suggested (15, 17, ...rat pancreatic is- lets cultured under hyperglycemic and hyperlipacidemic ...
9
Taurine regulates insulin release from pancreatic beta cell lines
... (p<0.001) compared to controls. As with the Hit cells, insulin immunoreactivity in the presence of 3 mM glu- cose, while significantly lower than controls, were not significantly different from each other (p>0.05). ...
8
The Role of OATP-Mediated Statin Transport in Pancreatic Beta Cell Function
... β cell-failure. Moreover, islets of mice with β-cell specific deficiency of Hnf4a showed impaired insulin secretion after stimulation by glucose or sulfonylurea derivatives (Miura et ...
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