Paneth cell
Gastroesophageal junction Paneth cell carcinoma with extensive cystic and secretory features – case report and literature review
... of Paneth cell lesion has not been carefully examined. Paneth cell metaplasia in pre-neoplastic lesions seems to render a favorable progno- ...of Paneth cell metaplasia in ...
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NOD2 up-regulates TLR2-mediated IL-23p19 expression via NF- κB subunit c-Rel in Paneth cell-like cells
... Paneth cell (PC)-like cells were generated by treatment of Caco2 cells with FGF9 (10 ng/ml) daily for 3 consecutive days as our described previously [35, ...sub-confluent cell density onto 6-well ...
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LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn’s disease patients
... of Paneth cell pheno- type in CD, a more detailed understanding of the genet- ic determinants of Paneth cell phenotype and further clinical validation are ...of Paneth cell ...of ...
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Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn’s disease
... abnormal Paneth cells do not yet have mouse models of their respective genetic ...that Paneth cell defects are induced in hypomorphic Atg16l1 mice after MNV infection, we are unable to yet identify ...
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Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
... of Paneth cells from different animals tend to exhibit bipartite substructure with a peripheral halo of lower density around a large round central core of high electron density ...Intermediate Paneth/goblet ...
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Paneth cell metaplasia in newly diagnosed inflammatory bowel disease in children
... Decreased Paneth cell activity in the terminal ileum in a subset of patients with ileal CD who have mutations of the susceptibility gene NOD2 may be an early or initiating factor in their disease ...of ...
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Paneth cell defects in Crohn’s disease patients promote dysbiosis
... intestinal Paneth cells are a candidate biomarker. Paneth cells are secretory epithelial cells important in innate immunity ...processing Paneth cell α-defensins in mice, increases ...
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Enteroendocrine cells sensory sentinels of the intestinal environment and orchestrators of mucosal immunity
... to Paneth cell occurrence in the colon 138 , gastrin+ cells are strangely found in the repairing small intestine of CD patients 131 and subsets of IBD patients have autoantibodies to gastrin 139 ...via ...
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Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice
... Although Paneth cell granules were present in the crypts of double heterozygous mice (Figure 8, B and C), the electron intensities of Paneth cell granules were markedly reduced in comparison ...
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Zwarycz_unc_0153D_17727.pdf
... Isomaltase), Paneth (Lyz2, Lysozyme2), goblet, (Muc2, Mucin2), and enteroendocrine (ChgA, Chromogranin A) (Figure ...with Paneth cell lineage, was significantly ...the Paneth cell ...
152
Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis
... regulates Paneth cell differentiation and ...of Paneth cells in the Dvl1 mutant (Figure 4) is strongly supported by multiple studies focused on the effect of Wnt signaling on Paneth ...and ...
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Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft versus host disease
... Figure 2. Time course of REG3γ and IL-22 expression during GVHD. (A–C) B6D2F1 mice underwent BMT from syngeneic B6D2F1 donors (no GVHD, white circles) or allogeneic B6 donors (GVHD, black or blue circles), and samples ...
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Regulatory role of defensins in inflammatory bowel disease
... showed Paneth cell products remained unchanged or ...and Paneth cell α-defensins [45]. It is reported a decrease of Paneth cell α-defensin mRNA expression in mice lacking the ...
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Ileal antimicrobial peptide expression is dysregulated in old age
... the cell wall-degrading enzyme lysozyme) were chosen for comparative gene expression analyses in the terminal ...creased Paneth cell numbers, transcript levels for Defa20 (a member of the α-defensins ...
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A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells
... the Paneth cell–specific protein, defensin α-6 (DEFA6) (Figure 3A), and were shown to contain secretory granules by TEM (Figure ...enteroendocrine cell marker, was lower in gut organoids than in the ...
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Original Article Stem Cells might Participate in the Cell Turnover of Duodenal Adenomas
... Mature Paneth cells were those showing coarse brightly red cytoplasmic granules in H&E stain and Paneth cell precursors were those lysozyme-expressing cells that had remained undetected in ...
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Intestinal Structure and Injury of Extremely Premature Lambs During Artificial Placenta Support
... . Paneth cells first appear in the first trimester of pregnancy, mature by the age of viability (22-24 weeks), and then increase in number by full term gestation 32 ...mature paneth cells that then work as ...
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Macaque Paneth Cells Express Lymphoid Chemokine CXCL13 and Other Antimicrobial Peptides Not Previously Described as Expressed in Intestinal Crypts
... by Paneth cells. Paneth cells are specialized intestinal epithelial cells that express AMPs and proinflammatory cytokines that contribute to innate immunity ...by Paneth cells have several ...
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The role of TGFß-Activated Kinase 1 Signaling in Reactive Oxygen Species and Intestinal Homeostasis.
... specific cell type of the intestinal epithelium, Paneth cells, was depleted in the Tak1-deficient small intestine (shown in the current ...study). Paneth cells reside at the base of the crypts in the ...
116
Celecoxib suppresses cutaneous squamous-cell carcinoma cell migration via inhibition of SDF1-induced endocytosis of CXCR4
... further, cell migration was examined by chemotaxis assay in response to SDF1 with/without MDC or ...the cell migration induced by SDF1 (Figure 2A and ...on cell migration induced by SDF1, but did not ...
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