Paneth cells
Macaque Paneth Cells Express Lymphoid Chemokine CXCL13 and Other Antimicrobial Peptides Not Previously Described as Expressed in Intestinal Crypts
... CXCL13 is a constitutively expressed chemokine that controls migration of immune cells to lymphoid follicles. Previously, we found CXCL13 mRNA levels increased in rhesus macaque spleen tissues during AIDS. This ...
9
Plasticity of Paneth cells and their ability to regulate intestinal stem cells
... Paneth cells affect intestinal stem cells in ageing Ageing is an inevitable biological event and is usually ac- companied by decreased function, including diminished self-renewal ability of stem ...
13
Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge
... these cells did not up-regulate IL‑23 mRNA expression in vivo within the first 2h of infection whereas primary epithelial cells did in our in vivo and in vitro model ...epithelial cells, similar in ...
16
Paneth cell defects in Crohn’s disease patients promote dysbiosis
... I Paneth cell phenotype is associ- ated with reduced expression of genes involved in oxidative ...17) Paneth CD ...with Paneth cell phenotype in CD patients (n = 38) but not in non-IBD patients (n = ...
16
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice
... stem cells maintains a functional intestinal mucosa for a ...stem cells had cell division defects, reduced capacity for clonal expansion and differentia- tion into Paneth cells, and increased ...
15
Intestinal Structure and Injury of Extremely Premature Lambs During Artificial Placenta Support
... . Paneth cells first appear in the first trimester of pregnancy, mature by the age of viability (22-24 weeks), and then increase in number by full term gestation 32 ...mature paneth cells that ...
31
Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft versus host disease
... of Paneth cells (Figure 1, A–C) and observed a similar inverse correlation in 2 mouse models of GVHD (Figure 1, D–I, and Supplemental Figure 1; supplemental material available online with this article; ...
11
Ileal antimicrobial peptide expression is dysregulated in old age
... In an effort to understand the mechanisms underlying the high prevalence of gastrointestinal tract disorders in old age, we investigated the expression of intestinal antimicrobial peptides in the terminal small intestine ...
5
Gastroesophageal junction Paneth cell carcinoma with extensive cystic and secretory features – case report and literature review
... of Paneth cell lesion has not been carefully examined. Paneth cell metaplasia in pre-neoplastic lesions seems to render a favorable progno- ...of Paneth cell metaplasia in Barrett esophagus was ...
6
Gut microbiota, probiotics and diabetes
... of Paneth cells [96]. Paneth cells are constitu- ents of the intestinal barrier which produce antimicrobial proteins, contributing to reduce intestinal permeability ...
13
LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn’s disease patients
... normal Paneth cells between North American CD and Japanese CD were compared by unpaired t test, and the prevalence of type I Paneth cell phenotype between the 2 groups was compared using Fisher’s ...
15
Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis
... Paneth cells secrete antimicrobial peptides such as defensins and lysozyme to control the microbial content of the ...G). Paneth cells not only control populations of potentially pathogenic ...
19
Paneth cell metaplasia in newly diagnosed inflammatory bowel disease in children
... of Paneth cells in the first ten well-orientated crypts was counted by an experienced histopathologist (NS or ...which Paneth cells were counted, acute and chronic inflammation were scored ...
6
Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
... of Paneth cells from different animals tend to exhibit bipartite substructure with a peripheral halo of lower density around a large round central core of high electron density ...Intermediate ...
9
NOD2 up-regulates TLR2-mediated IL-23p19 expression via NF- κB subunit c-Rel in Paneth cell-like cells
... (PC)-like cells were generated by treatment of Caco2 cells with FGF9 (10 ng/ml) daily for 3 consecutive days as our described previously [35, ...These cells were cultured in Dulbecco’s modified Eagle ...
10
Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn’s disease
... abnormal Paneth cells do not yet have mouse models of their respective genetic ...that Paneth cell defects are induced in hypomorphic Atg16l1 mice after MNV infection, we are unable to yet identify ...
14
Original Article Stem Cells might Participate in the Cell Turnover of Duodenal Adenomas
... stem cells, spatially confined to the lower part of the crypt, are able to self-renew through life generating several types of more committed precursor cells that actively divide within the proliferative ...
5
A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells
... stem cells (hPSCs) can be induced to differentiate into various cell types by manipulat- ing developmental signals, first to generate germ layers and then to produce distinct cell types, such as pancre- atic β ...
14
Regulatory role of defensins in inflammatory bowel disease
... phagocytes, Paneth cells, and intestinal epithelial ...various cells, including neutrophils, monocytes, T-lymphocytes, den- dritic cells, and epithelial ...by Paneth cells ...
7
The role of TGFß-Activated Kinase 1 Signaling in Reactive Oxygen Species and Intestinal Homeostasis.
... epithelium, Paneth cells, was depleted in the Tak1-deficient small intestine (shown in the current ...study). Paneth cells reside at the base of the crypts in the small intestine and are ...
116