Paracrine Factors
Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation
... contains paracrine factors which can recruit osteoprogenitors (MSCs and osteoblasts) from the niche to the site of loading, enhance proliferation of progenitors to ensure sufficient numbers and lastly ...
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Use of paracrine factors from stem cells to treat local radiation burns in rats
... The paracrine bioactive factors are produced by mesen- chymal stem cells (MSCs) that deploy their task by paracrine factors as an essential mechanism, but their efficiency to regenerate still ...
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Adipose stem cells and their paracrine factors are therapeutic for early retinal complications of diabetes in the Ins2Akita mouse
... MSC-secreted factors coordinate with controlled re- cruitment of immune regulators with influence over their phenotype and function at the site of injury while simul- taneously initiating the process of tissue ...
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Adult mouse epicardium modulates myocardial injury by secreting paracrine factors
... and paracrine contributions to the growth of the fetal myocardium and the formation of the coronary ...secreted paracrine factors that strongly promoted angio- ...
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Cell plasticity in wound healing: paracrine factors of M1/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts
... of paracrine fac- tors secreted by human M1 and M2 macrophages on primary adult human dermal fibroblasts (HDFs) with re- spect to proliferation, myofibroblast formation, collagen synthesis and degradation, as well ...
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Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development
... Creating complex multicellular kidney organoids from pluripotent stem cells show great promise. Further improvements in differentiation outcomes, patterning, and maturation of specific cell types are, however, ...
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Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity?
... growth factors. A role for paracrine signaling pathways in mammary gland development was first sug- gested by studies in which there was a dissociation of the localization of estrogen receptor (ER)-positive ...
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Biology of primate relaxin: A paracrine signal in early pregnancy?
... that paracrine factors associated with this response may be responsible for limitation of the reaction to specific areas despite high circulating levels of CG ...local paracrine effect of relaxin at ...
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Role and therapeutic effects of skeletal muscle-derived non-myogenic cells in a rat myocardial infarction model
... angiogenic factors in vitro and promoted angiogenesis in vitro and in a rat MI model, suggesting that NMCs exhibited therapeutic effects based on the production of angiogenic paracrine factors and ...
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The art of oocyte meiotic arrest regulation
... like factors. The EGF or EGF-like factors in the mural granulosa cells act as autocrine factors to binds to its membrane EGF receptor (EGFR) to cause the decrease of NPPC; On the other side, these ...
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Preconditioning diabetic mesenchymal stem cells with myogenic medium increases their ability to repair diabetic heart
... with paracrine factors (IGF-1, HGF, SDF-1, FGF-2) and, in addition, reduced fibrosis, apoptosis, and increased angiogenesis was observed in diabetic hearts 4 weeks after transplantation of preconditioned ...
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Adolescent Varicocele: Who Is at Risk?
... The prevalence of varicocele among all investigated chil- dren was 4.1%. Only left-sided varicocele was found. The presenting complaint was asymptomatic in almost all affected boys. The frequency of the disease was ex- ...
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Dental pulp stem cells : an attractive alternative for cell therapy in ischemic stroke
... During ischemia, neurons are unable to maintain normal transmembrane ion gradient and balance, resulting in cell death by apoptosis, excitatory toxicity, and oxidative stress. Inflammatory reactions contribute to cell ...
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Gene Expression Profiling in Surrogate Tissues to Identify Biomarkers Following Conazole Exposure
... Six of the 48 significantly changed genes from the blood microarray data encode proteins involved in nucleic acid binding or act as transcription factors (Table 4). Histone 2A, Pituitary- tumor transforming 1, ...
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Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee
... Background: Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a ...
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Paracrine effect of bone marrow mesenchymal stem cells on proliferation, apoptosis, and alpha-actin-2 expression in hepatic stellate cells.
... MSC paracrine material contained something with a therapeutic ...MSC paracrine material can inhibit HSC proliferation and induce HSC apoptosis by the HGF/c-met signal, RohA, ...
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Régulation paracrine des fonctions leydigiennes
... C o m m e dans les modules animaux, les cellules de Sertoli appa- raissent capables de favoriser l'expression des fonctions diffErenciEes des cellules de Leydig, m~me si dans [r] ...
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Disentangling juxtacrine from paracrine signalling in dynamic tissue
... in Materials and Methods. With three replicated datasets, the solid horizontal lines represent the means of upper and lower bounds, whose precise definitions are given in Materials and Methods, while the shade is defined ...
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Rotavirus NSP1 Protein Inhibits Interferon-Mediated STAT1 Activation
... and paracrine manner, are early critical mediators of this host antiviral program in most cell ...transcription factors IFN regulatory factor 3 (IRF3) and NF- B, both of which are required for the ...
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Search | Preprints
... MSC are active participants of tissue formation since ontogenetic development [12]. Early stages of development are driven by embryonic stem cells’ (ESCs) ability for self-organization yet later they rely on other cells ...
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