Paraoxonase 1
Original Article Comparison of maternal serum vitamin D and paraoxonase 1 levels and neutrophil to lymphocyte ratios of preeclamptic and severe preeclamptic, and normal pregnant women
... Preeclampsia is a pregnancy-specific multisys- tem disorder characterized by de novo-onset hypertension with a spectrum of systemic de- rangements. Despite intensive research activi- ty to delineate the pathophysiology ...
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“Paraoxonase 1 in Type 2 Diabetes Mellitus - A Review” by A. Jamuna Rani, S.V.Mythili, India.
... by Paraoxonase 1 (PON 1). 1 In fact, previous studies have shown that PON1 is able to hydrolyze preformed lipid hydroperoxides and to delay or inhibit the initiation of oxidation induced by ...
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Original Article Risk association of polycystic ovary syndrome with paraoxonase 1 and TNF-α gene polymorphisms: a meta-analysis
... Enzyme paraoxonase 1 (PON-1) is a calcium- dependent multifunctional enzyme mainly ex- pressed by the liver, which is associated with high density lipoproteins (HDLP) and impeded atherogenic ...
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Paraoxonase 1 Activity, Lipid Profile, and Atherogenic Indexes Status in Coronary Heart Disease
... 11. Van Himbergen TM, van Tits LJ, Hectors MP, de Graaf J, Roest M, Stalenhoef AF. Paraoxonase-1 and linoleic acid oxidation in familial hypercholesterolemia. Biochem Biophys Res Commun. 2005; 333(3): ...
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Reduced serum paraoxonase 1 (PON1) activity in patients with schizophrenia treated with olanzapine but not quetiapine
... rising. Paraoxonase 1 (PON1) is an enzyme mostly located on high-density lipoprotein particles, and has been shown to protect or inhibit lipoprotein ...
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Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response
... Background: The metabolic activation of clopidogrel is a two-step process. It has been suggested that paraoxonase-1 (PON1) is a rate-limiting enzyme in the conversion of 2- oxo-clopidogrel to an active ...
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Paraoxonase 1 Response to a High-Fat Diet: Gender Differences in the Factors Involved
... serum Paraoxonase 1 (PON1) activity, and given the pro-atherogenic effects described for saturated fatty acids (SFA), as opposed to the beneficial ones conferred to mo- nounsaturated fatty acids (MUFA), the ...
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The Effect of Exercise on Paraoxonase-1 Activity and Lipid Profile in Obesity and Insulin Resistance Conditions
... in cerebral vascular diseases, resulting in decreased blood flow to the brain and irreversible changes of the brain tissue, which is an important case of ischemic stroke (24). The PON-1 activity is markedly ...
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Relationship between MPV and paraoxonase-1 activity, brachial artery diameter and IMT in patients with diabetes mellitus
... Human paraoxonase 1/arylesterase (PON1), which has antioxidant and antiatherogenic properties, is documented in high oxidative stress conditions like uncontrolled ...and paraoxonase-1 ...
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Increased Levels of Acetylcholinesterase, Paraoxonase 1, and Copper in Patients with Moderate Depression- a Preliminary Study
... Serum paraoxonase and arylesterase activities and oxidative stress levels in patients with SSRI ...of paraoxonase-1 activity and major depressive disorder in patients with metabolic ...
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The Relation of Lumbar Disc Herniation With Increased Lipid Hydroperoxide, Paraoxonase 1 and Total Oxidative Status
... Objective: Lumbar disc herniation (LDH) is well known low back disorder. Beside a lot of reason, the chronic inflammation is stated to have a role in the importance of LDH. As known, there is a complex connection between ...
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Review Article Genetic variants of the paraoxonase 1 gene and risk of coronary heart disease and stroke in the Chinese population: a meta-analysis
... of paraoxonase 1 (PON1) - Q192R and L55M - have been implicated as po- tential risk factors for these diseases; however, the results from individual studies are ...
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Two common nonsynonymous paraoxonase 1 (PON1) gene polymorphisms and brain astrocytoma and meningioma
... Human serum paraoxonase 1 (PON1), a enzyme encoded by the polymorphic gene PON1 on chromo- some 7q21.3, is an aryldialkylphosphatase, synthesized mainly in the liver, that plays a major role in the meta- ...
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Original Article Amendment of amino acid in Q192R genetic polymorphism of paraoxonase 1 is a conventional risk factor for type 2 diabetes mellitus in the Saudi population
... The paraoxonase 1 (PON1) gene polymorphism Q192R has been found to be consistent with multiple metabolic diseases comprising type 2 diabetes mellitus ...
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A Study of Serum Paraoxonase-1 Activity in Patients with Metabolic Syndrome
... SERUM PARAOXONASE-1 ACTIVITY IN PATIENTS WITH METABOLIC SYNDROME” was done by me at Thanjavur Medical College and Hospital, Thanjavur under the Supervision and Guidance of my Professor and Head of the ...
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Ocimum sanctum Linn leaves ameliorates cardiac toxicity by enhancing paraoxonase 1 activity and expression of heart type fatty acid binding protein
... of paraoxonase 1 (PON1) and mRNA expression of heart type fatty acid binding protein (H-FABP) in isoproterenol (ISP) induced cardiac ...follows: 1) Control, 2) MOS (15mg/100g ...
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Myeloperoxidase, paraoxonase 1, and HDL form a functional ternary complex
... in paraoxonase 1 (PON1), an atheroprotec- tive protein (14), have been linked to the antioxidative, antiinflam- matory, and lipid cargo–carrying functions of HDL (7, 12, ...
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Salt overload in fructose-fed insulin-resistant rats decreases paraoxonase-1 activity
... Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a ...
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Paraoxonase 1 polymorphism Q192R affects the pro inflammatory cytokine TNF alpha in healthy males
... In addition to TNF alpha, we found that levels of a second pro-inflammatory cytokine MCP-1 were slightly although not significantly enhanced in R192 carriers that usually express PON1 allozymes with less antioxi- ...
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Tratment With Folic Acid Increases Paraoxonase 1 Activity Thereby Improving Chronic Kidney Disease
... Table 1 shows the baseline characteristics of CKD patients treated with and without folic acid. There were no significant differences between both treatment groups in any of the demographic data including age, ...
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