parasitic worm
Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus
... the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus ...of parasitic worms can exhibit therapeutic potential as a novel ...
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Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis
... Rzepecka, J., Pineda, M.A., Al-Riyami, L., Rodgers, D.T., Huggan, J.K., Lumb, F.E., Khalaf, A.I., Meakin, P.J., Corbet, M., Ashford, M.L., Suckling, C.J., Harnett, M.M. and Harnett, W. (2015b) Prophylactic and ...
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The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma
... the parasitic worm Acanthocheilonema viteae, can prevent pathology associated with chronic asthma (cellular infiltration of the lungs, particularly neutrophils and mast cells, mucus hyper-production and ...
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The parasitic worm product ES-62 up-regulates IL-22 production by γδ T cells in the murine model of collagen-induced arthritis
... ES-62 is a phosphorylcholine (PC)-containing glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that acts to modulate the host immune response to promote the establishment of chronic helminth ...
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The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model.
... defined parasitic worm product with therapeutic potential in atherosclerosis: ES-62-based drugs may represent a novel approach to control accelerated atherosclerosis in ...
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IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62
... secreted parasitic worm-derived immunomodulator that exhibits therapeutic potential in allergy by downregulating aberrant MyD88 signalling to normalise the inflammatory phenotype and mast cell ...the ...
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Small molecule analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling
... ES-62 is a protein secreted by the parasitic worm Acanthocheilonema viteae that is anti-inflammatory by virtue of covalently attached phosphorylcholine. Previously we have reported that drug-like Small ...
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Site-specific glycoproteomic characterization of ES-62 : the major secreted product of the parasitic worm Acanthocheilonema viteae
... developing parasitic worm- derived molecules as therapeutics for the treatment of a range of human ailments associated with aberrant inflammatory responses (reviewed by Harnett and Harnett ...
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Failure of the anti-inflammatory parasitic worm product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory bowel disease
... Abstract: Parasitic helminths and their isolated secreted products show promise as novel treatments for allergic and autoimmune conditions in humans. Foremost amongst the secreted products is ES-62, a glycoprotein ...
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Protection against arthritis by the parasitic worm product ES-62, and its drug-like small molecule analogues, is associated with inhibition of osteoclastogenesis
... The differential effects of ES-62 and the SMAs in vitro with respect to differentiation of OCs from BM derived from naïve C57BL/6 mice may simply reflect the higher (~10-fold) molar concentrations of the SMAs relative to ...
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Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62
... the parasitic filarial nematode Acanthocheilonema viteae, subverts host immune responses towards anti-inflammatory phenotypes by virtue of covalently attached phosphorylcholine ...
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The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62
... ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, has been shown to modulate the immune system through subversion of signal transduction pathways operating in various immune system cells. ...
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The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis
... The human immune system has evolved in the context of our colonisation by bacteria, viruses, fungi and parasitic helminths. Reflecting this, the rapid eradication of pathogens appears to have resulted in reduced ...
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The role played by alternative splicing in antigenic variability in human endo parasites
... as parasitic infections affect the host immune system resulting in higher HIV infection rates, faster disease progression, and an increase in the severity of infections and complications in HIV ...the ...
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Earthworms: Interactions with management; impacting plant growth?
... Aporrectodea caliginosa = Grey worm Field worm, found north to Finnmark 71°N Aporrectodea rosea = Rosy-tipped worm, found north to Tromsø 69° N Lumbricus rubellus = Red worm, found north[r] ...
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ADIEU ! GUINEA WORM
... guinea worm cases such as bandaging of ulcers and distribution of drugs like antibiotic ointments, analgesics ...Guinea Worm disease from Pakistan is the year ...
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Does a Restricted Quintic Polynomial in Minimum Time Step (Planck Time Interval) Being Solvable in a Galois Theory Sense Affect the Closing of a Wormhole Throat if (Kaluza Klein Theory) Is Assumed and Impact Admissible Gravitational Wave Polarization?
... and Valev indicates in his article that this gives a light year, or more length GW of unimaginably low frequency. Obviously, in terms of experimental conditions, this breaks down, i . e . in the limit of say a simulated ...
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THE V-NETWORK: A TESTBED FOR MALWARE ANALYSIS
... a worm daemon developed by Shahzad and Woodhead (2014) with the capabilities of facilitating a worm attack event using chosen worm ...The worm system consists of both client and server modules ...
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virus-worm-trojan_horse.docx
... Does this software qualify as Trojan Horse software?.. The Sony DRM Fiasco[r] ...
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EDOWA Worm Classification
... Static analysis is also known as white box analysis. It involves analyzing and understanding source code. If only binary code available, the binary code has to be compiled to get the source code. White box analysis is ...
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