Partial Hepatectomy
Original Article Efficacy and safety analysis of enhanced recovery after partial hepatectomy for hepatocellular carcinoma: a controlled study with propensity score matching
... because partial hepatectomy is often performed on patients with hepatocellular carcinoma (HCC), but it carries a high risk of postoperative mor- tality and ...
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Effect of 5-HT7receptor blockade on liver regeneration after 60-70% partial hepatectomy
... after partial hepatectomy greatly attenuated liver regeneration as evaluated by [ 3 H]-thymidine incorpor- ation into hepatic DNA at 24 h after partial hepatectomy (Figure ...after ...
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CCAAT enhancer binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy
... During the proliferative response posthepatectomy, the liver must also maintain organ-specific functions that are nec- essary for synthetic and metabolic homeostasis (1). In re- sponse to the abrupt loss of glycogen ...
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Expression profiles uncover the relationship between erythropoietin and cell proliferation in rat hepatocytes after a partial hepatectomy
... The liver has the unique capacity to regain its original and optimal mass after damage due to various events, such as partial hepatectomy (PH), viral infection, and intoxication [1, 2]. Liver regeneration ...
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Organogenesis: A New Theme to Study Genetic Expression in Adult Liver Regeneration After Partial Hepatectomy
... The liver has a unique ability to regenerate and to retain a specific three-dimensional shape after partial hepatectomy; researchers investigated the liver’s abilities because of the multiple factors ...
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Liver regeneration: immunohistochemichal study of intrinsic hepatic innervation after partial hepatectomy in rats
... Fifty six male Wistar rats, with a mean weight of 283 g, were purchased by the National Centre of Scientific Re- search “ DEMOKRITOS ” (Athens, Greece). The animals had free access to water and food, and 12 h before sur- ...
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Partial hepatectomy induces delayed hepatocyte proliferation and normal liver regeneration in ovariectomized mice
... Notes: (A) The time course of the OVXs and Phs are illustrated in B–D. (B and C) Control (Cont) and OVX B6 female mice underwent Ph operations; the liver weight recovery (B) and hepatocyte proliferation were analyzed by ...
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Partial hepatectomy for spontaneous tumor rupture in patients with hepatocellular carcinoma: a retrospective cohort study
... between the two groups. Patients with ruptured HCC were more likely to present with more intraoperative blood loss (P = 0.006) and intraoperative blood transfusion (P < 0.001) but without a longer duration of ...
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Does Simple Steatosis Affect Liver Regeneration after Partial Hepatectomy in Rats?
... 2/3 partial hepatectomy (n = 6 in each group) (65–70% of the liver tissue was removed comprising left lateral and median lobules of the liver) described by Higgins and An- derson (3) or laparotomy (sham ...
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Original Article Partial hepatectomy promotes pancreatic regeneration through HGF/Gab1 pathway in db/db mice
... in Hepatectomy group (p< ...and Hepatectomy). Meanwhile, insulin secretion in Hepatectomy group was significantly higher than Control and Sham group (Figure ...in Hepatectomy group (Figure ...
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Defective Initiation of Liver Regeneration in Osteopontin-Deficient Mice after Partial Hepatectomy due to Insufficient Activation of IL-6/Stat3 Pathway
... age-matched WT mice were subjected to two-thirds partial hepatectomy (PHx) as previously described [14]. Briefly, after anesthetization, the left lateral lobe and the median lobe plus gall bladder were ...
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Interleukin-6 is required for cell cycle arrest and activation of DNA repair enzymes after partial hepatectomy in mice
... IL-6 Is Important for Survival after 70% PH in Mice We performed 70% PH in WT mice, in IL-6 KO mice, and in IL-6 KO mice that were treated 30 minutes be- fore surgery with subcutaneous (SC) injections of re- combinant ...
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Original Article Nrf2 modulates cell proliferation and antioxidants defenses during liver regeneration induced by partial hepatectomy
... Abstract: The objective was to determine the regulatory dynamic of Nrf2 during liver regeneration and the admin- istration of EtOH and/or the G. schiedeanum extract. Male Wistar rats weighing 200-230 g were subjected to ...
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Original Article Partial hepatectomy promotes implanted mouse hepatic tumor growth by activating hedgehog signaling
... cant differences (P < 0.01). However, the im- planted tumor volumes were not significantly different between groups A and B (P > 0.05). Furthermore, group C had significantly larger tumor volumes than groups A and ...
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Immunohistochemical Study of the Ameliorative Effect of Vitamin E on Liver Regeneration after Different Periods of Partial Hepatectomy
... to partial hepatectomy, it was significantly elevated as compared to the control group to reach a maximal peak (90 ± ...the partial hepatectomy with vitamin E pretreatment subgroups, the PCNA ...
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Proteomic analysis of the regenerating liver following 2/3 partial hepatectomy in rats
... the removal of approximately 75% of liver volume was tolerable for normal rodents, but the resection of more than 75% of liver mass often leads to liver failure and death. Accordingly, to induce maximal hepatic regener- ...
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Early increases in plasminogen activator activity following partial hepatectomy in humans
... Zymography clearly showed several plasminogen activa- tors to be associated with the membrane fractions. As expected, the major bands corresponded to the high molecular weight uPA and tPA markers. Although uPA and its ...
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Metabolomics Analysis of the Responses to Partial Hepatectomy in Hepatocellular Carcinoma Patients
... It is important to note firstly that the number of patient cohort was small but still may be scientifically important, and bear further investigation in a large population. Sec- ondly, the sera were collected from pre- ...
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LYVE1 and PROX1 in the reconstruction of hepatic sinusoids after partial hepatectomy in mice
... PROX1, mainly present in hepatic progenitors [24], has an important role in the regulation of hepato- cyte proliferation and migration [11, 26]. However, PROX1 is absent from hepatic sinusoids or venous endothelia due to ...
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Modulation of Rat Liver Regeneration after Partial Hepatectomy by Dietary Cholesterol
... third partial hepatectomy (PH) and then were sacrificed 18 hours (8 + 8 rats, SLD-18, CHOL-18), and 24 hours (8 + 8 rats, SLD-24, CHOL-24) after partial hepa- tectomy ...
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