PATHOGENESIS AND IMMUNITY
A Mouse Model for the Evaluation of Pathogenesis and Immunity to Influenza A (H5N1) Viruses Isolated from Humans
... Although the ferret model has been widely used for the study of other influenza A viruses, it has not yet been shown to be a suitable animal model for the study of human H5N1 viruses in vivo. In contrast, the BALB/c ...
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Role of innate immunity and microbial component in the skin and pathogenesis of psoriasis
... the pathogenesis of this dermatosis is the antigenic stimulation of immune competent cells, which results in development of inflammatory process in the surface layers of the ...innate immunity, namely ...
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T Lymphocytes Contribute to Antiviral Immunity and Pathogenesis in Experimental Human Metapneumovirus Infection
... the pathogenesis of hMPV-induced lower airway disease are largely ...viral immunity against hMPV, as well as contributing to lung disease, is not fully ...the pathogenesis of ...
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Impact of host immunity on HTLV 1 pathogenesis: potential of Tax targeted immunotherapy against ATL
... innate immunity in the switch between lymphoproliferative and inflammatory diseases as well as the regulation of HTLV-1 ...HTLV-1 pathogenesis, at least in part, and encour- age Tax-targeted immunotherapy ...
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Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral Evasion
... WNV pathogenesis and im- mune system-mediated ...innate immunity, humoral immunity, and T-cell-mediated im- munity are all required to orchestrate effective control of ...
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<p>Innate Immunity and Cell Surface Receptors in the Pathogenesis of COPD: Insights from Mouse Smoking Models</p>
... of Immunity in the Pathogenesis of Pulmonary Lesions Many elements of the innate and adaptive immune responses are abnormal in ...COPD pathogenesis; however, some experimental evi- dence supports a ...
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Subinhibitory Antibiotic Therapy Alters Recurrent Urinary Tract Infection Pathogenesis through Modulation of Bacterial Virulence and Host Immunity
... IMPORTANCE Antibiotics are the mainstay treatment for bacterial infections; however, evidence is emerging that argues these agents may have off-target effects if sublethal concentrations are present. Most studies have ...
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A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity
... HSV-1 pathogenesis and ocular pathology is prophylactic vac- cine-mediated humoral ...humoral immunity against HSV-1 that prevents expansion of T cells in draining lymph nodes upon viral challenge and ...
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Animal Models of Zika Virus Infection, Pathogenesis, and Immunity
... ABSTRACT Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has received global attention because of some of its ...
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Investigation of the interaction of European porcine reproductive and respiratory syndrome virus with porcine antigen-presenting cells: implications for pathogenesis and immunity
... clearly observable in infected samples (data not illustrated, data-set in Figure 4.9) When assessing AMΦ and monocyte-derived cell surface marker expression in the context of PRRSV-1[r] ...
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Innate immunity in COVID-19: Drivers of pathogenesis and potential therapeutic targets
... Abstract A novel severe acute respiratory syndrome COVID-19 caused by coronavirus SARS-CoV-2 has been confirmed to in- fect more than 100 million people globally, with mortality reaching nearly 3 million as of March ...
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Cellular and Humoral Immunity in the Pathogenesis of Recurrent Herpes Viral Infections in Patients with Lymphoma
... Cellular immunity to the viral antigens was measured by in vitro lymphocyte transformation and interferon ...cellular immunity, including T-cell quantitation and transformation ...
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Gut barrier structure, mucosal immunity and intestinal microbiota in the pathogenesis and treatment of HIV infection
... Camilla Tincati 1 , Daniel C. Douek 2 and Giulia Marchetti 1* Abstract Over the past 10 years, extensive work has been carried out in the field of microbial translocation in HIV infection, ranging from studies on its ...
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The role of virus-specific T cell immunity in the pathogenesis of acute and chronic Hepatitis B virus infection
... exceeded the clearance capacity of the virus-specific CTL, lung pathology resulted. Interestingly, treatment with anti-IFN-y antibody prevented lung pathology by blocking the recruitment of large numbers of activated ...
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The Cotton Rat (Sigmodon hispidus) Is a Permissive Small Animal Model of Human Metapneumovirus Infection, Pathogenesis, and Protective Immunity
... Appropriate animal models are critical to investigate the roles of these factors in pathogenesis. Inbred strains of mice, particularly the BALB/c strain, have been used extensively as small animal models of RSV ...
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Severe Malarial Anemia: Innate Immunity and Pathogenesis
... Abstract Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in im- mune-naïve infants and young ...
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Antibody Responses to DNA in Normal Immunity and Aberrant Immunity
... This serologic approach could be especially useful for evaluat- ing infections caused by organisms that are difficult to culture. The role of immunostimulatory DNA in the pathogenesis of infection is a topic of ...
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Altered homeostatic regulation of innate and adaptive immunity in lower gastrointestinal tract GVHD pathogenesis
... the microbiome, leading to changes in metabolites and the dimin- ished function of immunosuppressive mechanisms and cells such as Tregs. Our increased understanding of this complex system has led to a new understanding ...
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Pathogenesis of Periodontitis. Periodontal Medicine. Pathogenesis of Periodontitis. Pathogenesis of Periodontitis. Pathogenesis of Peri-implantitis
... – Absolute reduction in HbA1c in type 2 subjects who had periodontal treatment was 0.95% greater than control group (p=0.004). – No significant difference in HbA1c in type 1 DM subject[r] ...
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