Patient Derived Xenograft Model
Application of a patient-derived xenograft model in cytolytic viral activation therapy for nasopharyngeal carcinoma
... EBV is considered a therapeutic target in EBV-related cancers, including lymphoma and NPC [25]. Valproic acid, a short chain fatty acid used clinically as an anti-epilepsy drug, could have some HDAC-inhibitory effects ...
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Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model
... PDX model GA0087 established in this study revealed particularly high gene expression of VEGF-A and B, both of which have been recognized as having a significant role in early tumor development [9] and ...
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PCSD1, a new patient derived model of bone metastatic prostate cancer, is castrate resistant in the bone niche
... PCSD1 is a patient-derived xenograft model previously described in Raheem et al. [14]. Approval was received from the UCSD institutional review board (IRB) to col- lect surgical bone ...
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A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers
... Our model allows the study of intertumoral and interpa- tient heterogeneity by creating PDX models for different regions of disease from one patient and different patients, ...our model demonstrates ...
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Current status and perspectives of patient-derived xenograft models in cancer research
... PDX model of acute lymphoblastic leukemia (ALL), a rare unfavorable ALL subpopulation has been defined which is dormant and treatment resistant and mimics patients’ primary cells at minimal residual disease ...
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Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer
... 14 patient sam- ples of GC, out of which, 9 were successfully established the zPDX ...zPDX model [19], but much higher than that of the reported (34%) on mPDX model of GC ...
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Establishment and evaluation of four different types of patient-derived xenograft models
... years, patient derived xenografts (PDXs) have been used to evaluate targeted treatments for dif- ferent types of tumors, such as breast and non-small cell lung cancer, esophageal squamous cell ...the ...
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Evaluation of anti tumorigenic activity of BP3B against colon cancer with patient derived tumor xenograft model
... PDTX model exhibited very similar hist- ology and immunohistochemical phenotypes of patient ’ s original tumors and maintained the invasive/metastatic features even during serial subtransplantations in ...
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Identifying biomarkers of breast cancer micrometastatic disease in bone marrow using a patient derived xenograft mouse model
... a patient population at very high risk of recurrence, rela- tive to those patients who clear their DTCs with chemo- therapy [5, 27, ...cancer patient management, primarily due to the limited num- ber of ...
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Patient-derived xenograft models of colorectal cancer in pre- clinical research: a systematic review
... PDX model (by revealing clonal dynamics) rather than limit its usefulness [30], findings from the present review suggest that the risk of selection bias in CRC PDX models may be ...original patient samples ...
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Antitumor activity of the multikinase inhibitor regorafenib in patient-derived xenograft models of gastric cancer
... GC09-0109 model, levels of p-Ser 473 AKT, p-Thr 359 /Ser 363 p90RSK, p- Thr 421 /Ser 424 p70S6K, p-Ser 235/236 S6R, and p-Thr 70 4EBP1 appeared to be consistently reduced in the GC17- 0409 and GC28-1107 models, ...
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Establishment of patient derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract
... tumor morphology was well preserved in the PDXs showing strong resemblance to the respective human counterpart (Figure 1). Differentiation grades scored by a pathologist showed that tumor grade of the PDX model ...
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Novel patient derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin
... the patient, with a decrease in serum lipase and improvement in his quality of life ...PDTX model demonstrated growth inhibition to liposomal doxorubicin but the overall outcome was not significant (P = ...
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Characterization and assessment of the sensitivity and resistance of a newly established human gastrointestinal stromal tumour xenograft model to treatment with tyrosine kinase inhibitors
... GIST xenograft models described in the literature that have shown resistance to multiple ...GIST xenograft models reflecting the resistance pattern observed in the ...new model UZLX-GIST9 is ...
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Original Article Optimizing dosage regimen for FP3 based on vascular normalization window monitored by ratio of Ang-1 to Ang-2
... a patient-derived colorectal cancer xenograft model, which was demonstrated as FP3-sensitive, thus reliable for vascular normalization ...PDX model to both single FP3 and combined with ...
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Patient derived xenograft models of breast cancer and their predictive power
... Derivation of patient-derived xenograft models The use of preclinical models to test hypotheses is central to cancer research. Unfortunately, long-established human cell lines, and many transgenic ...
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Development of a Patient-Derived Xenograft (PDX) of Breast Cancer Bone Metastasis in a Zebrafish Model
... The patient was diagnosed with breast cancer in 1999 and a left radical mastectomy was performed, revealing invasive ductal carcinoma G2, pT1c (m), pN0, ...the patient developed pain in her left arm and an ...
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Failure of a patient-derived xenograft for brain tumor model prepared by implantation of tissue fragments
... using patient-derived tumorspheres [10, 22–24] and enzymatically dissociated cells ...GBM patient tumors may instead require injection of patient-derived tumor tissue ...
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Targeting heterogeneity of adrenocortical carcinoma: Evaluation and extension of preclinical tumor models to improve clinical translation
... pediatric xenograft model (SJ-ACC3) being available for this highly heterogeneous ...of patient-individual tumor models. During these studies, one xenograft (MUC-1) displayed marked ...
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Original Article Establishing a patient-derived colorectal cancer xenograft model for translational research
... original patient tumors (C74, C05, C11) with the fastest engraft- ment speed were compared with another 3 (C06, C54, C04) with the slowest engraft- ment speed (Supplemental Figure 1) in terms of tumor associated ...
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