PD-1/PD-L1 pathway
Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy
... death-ligand 1 (PD-L1) is a coinhibitory ligand that is predominantly expressed by tumor ...of PD-L1 to its receptor PD-1 has been demonstrated to induce an immune escape ...
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The importance of the PD 1/PD L1 pathway at the maternal fetal interface
... of PD-1 receptor expressed by immune cells at the human MFI [43, ...of PD-1+ CD3+ T cells in the first-trimester decidua compared to the endometrium in non-pregnant controls ...elevated ...
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The relationship between the PD-1/PD-L1 pathway and DNA mismatch repair in cervical cancer and its clinical significance
... the PD-1/PD-L1 pathway could be activated when ...the PD-1/PD-L1 negative immune pathway was closely related to cervical cancer, and more incidences ...
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The use of the PD-1/PD-L1 pathway as an immunotherapy in oncological diseases, autoimmune diseases and infectious diseases
... of PD-1 with its ligands PD-L1 and PD-L2, in turn, inhibits the effector function of T cells in peripheral ...target PD-L1. The expression of PD-L1 on tumor ...
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PD 1/PD L1 pathway in non small cell lung cancer and its relation with EGFR mutation
... that PD-L1 expression plays a crit- ical role in differentiation of regulatory T cells (Tregs) and maintaining their suppressive function ...microenvironment, PD-1/PD-L1- ...
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Modulating PD-L1 expression in multiple myeloma: an alternative strategy to target the PD-1/PD-L1 pathway
... of PD-L1 IHC for predicting response to immune checkpoint ...of PD-L1 by IHC is generally associated with a higher proportion of objective response, [72] patients without expression of ...
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The anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients
... of PD-1 positive (+) TILs in cancer ...of PD-1(+) TILs were significantly associated with prolonged disease-free survival of pulmonary squamous cell carcinoma (SqCC) patients ...of ...
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High-Resolution PET Imaging with Therapeutic Antibody-based PD-1/PD-L1 Checkpoint Tracers
... the PD-1/PD-L1 pathway have revolutionized ...both PD-1 and PD-L1 in immunocompetent ...for PD-1 and PD-L1 in secondary lymphoid ...
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Host expression of PD L1 determines efficacy of PD L1 pathway blockade–mediated tumor regression
... protein 1 (PD-1) pathway blockade is a promising therapy for treating ...tumor PD-L1 and PD-1 signaling to the therapeutic efficacy of PD-L1 and ...
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Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma
... of PD-L1 expression on neutrophils both in vitro and in ...Although PD-L1 expression has been observed on neutro- phils in patients with infectious diseases, such as patients who are infected ...
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Autophagy inhibition enhances PD-L1 expression in gastric cancer
... NF-κB pathway in many cell systems ...file 1: Figure ...on PD-L1 expression in NCI-n87 cells ...of PD-L1 by autophagy inhibition was not detected in AGS cells (Additional file ...
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Macrophage PD L1 strikes back: PD 1/PD L1 interaction drives macrophages toward regulatory subsets
... alter PD-1 expression. PD-1 deficient (PD-1-/-) mice were generated by deletion of the transmembrane and cytoplasmic domain exons, and some studies show the inhibitory role of ...
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Kupffer cells in immune activation and tolerance toward HBV/HCV infection
... the PD-1/PD-L1 signaling pathway was blocked by a PD-L1 ...the PD-1/PD-L1 signaling pathway by the binding of PD- L1 ...
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Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade
... Because PD-Ligand-1 (PD-L1) expression in other tumor types has been associated with response to anti-PD-1, we investigated the expression of PD-L1 and its ...
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Oncolytic virus and PD-1/PD-L1 blockade combination therapy
... Abstract: Oncolytic viruses are lytic for many types of cancers but are attenuated or repli- cation-defective in normal tissues. Aside from tumor lysis, oncolytic viruses can induce host immune responses against cancer ...
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Ongoing clinical trials of PD-1 and PD-L1 inhibitors for lung cancer in China
... When PD-1 binds to its ligands, such as programmed cell death protein ligand 1 (PD-L1) and programmed cell death protein ligand 2, T cell activity and cytokine production is greatly ...
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Prognostic value of PD-L1 and PD-1 expression in pulmonary neuroendocrine tumors
... of PD-L1 and PD-1 in 80 patients diagnosed with PNETs were inves- ...of PD-L1 (58.8%) and PD-1 ...Meanwhile, PD-L1 expression was associated with ...
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PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis
... ligands, PD-L1 and PD-L2, which may be expressed by both stromal and tumor cells ...The PD-1/PD-L1 axis is an inhibitory signaling pathway, causing T-cells ...
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Targeting PD-1/PD-L1 in lung cancer: current perspectives
... This trial included patients regardless of their PD-L1 status, and the primary endpoint was OS. In January 2015, the trial was stopped based on an assessment conducted by the inde- pendent Data Monitoring ...
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Immunotherapy in Merkel cell carcinoma: role of Avelumab
... enrolled, and all these patients received at least one dose of Avelumab which was given intravenously at a dose of 10 mg/kg every 2 weeks. Overall response rate (ORR) (either complete or partial response), which was the ...
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