PDE, Phosphodiesterase
The Dunce cAMP Phosphodiesterase PDE-4 Negatively Regulates Gαs-Dependent and Gαs-Independent cAMP Pools in the Caenorhabditis elegans Synaptic Signaling Network
... of pde-4(ce268) suggests, PDE-4 normally func- tions to inhibit locomotion, then overexpression of PDE-4 might confer sluggish ...the pde- 4d(1) cDNA driven by the rab-3 ...
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“Ameliorative Effects of Phosphodiesterase (PDE) Inhibitors in Potassium Dichromate-Induced Acute Renal Failure in Rats” by Abeer A. A. Salama, Rasha E. Mostafa, Enayat A. Omara, Egypt.
... of PDE inhibitors revealed that they attenuated renal expression of inducible nitric oxide synthase (iNOS) and participated in depressing inflammatory processes through decreasing renal content of ...of PDE ...
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Rieder, Florian (2004): Wirkung der spezifischen Phosphodiesterase-Inhibitoren Roflumilast und Pumafentrine im Mausmodell der Dextran-Sodium-Sulfat-induzierten Kolitis. Dissertation, LMU München: Medizinische Fakultät
... der PDE- Inhibitoren ...von PDE-Inhibitoren auf die Apoptose ist nicht ...der PDE eine antiapoptotische Wirkung zeigte (Ottonello at ...der PDE-Inhibitoren eine Rolle spielt, bedarf weiterer ...
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Role of adenylate cyclase, guanylate cyclase enzyme and phosphodiesterase isozyme modulation in animal models of epilepsy.
... findings, PDE-3 inhibitors possess transmembrane influx of Ca 2+ ...specific PDE-3 inhibitors and increase the cellular level of cAMP and Ca 2+ ions with the generation of ...
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Inhibitors of cyclic nucleotide phosphodiesterase isozymes type III and type IV suppress mitogenesis of rat mesangial cells
... cAMP- phosphodiesterase (PDE) isozyme PDE-III, inhibited mitogenesis to similar extent as forskolin and DBcAMP and activated in situ PKA, but without detectable increase in cAMP ...isozyme ...
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International Journal of Scientific Research and Modern Education (IJSRME) ISSN (Online): 2455 – 5630 www.rdmodernresearch.com) Volume I, Issue I, 2016
... against PDE-IV for potential anti- asthmatic effect, and against DPP-IV and PTP1B for potential anti-diabetic ...using phosphodiesterase IV enzyme (PDE-IV)[22](Table-5) and the primary screening of ...
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Murine AKAP7 Has a 2′,5′ Phosphodiesterase Domain That Can Complement an Inactive Murine Coronavirus ns2 Gene
... AKAP7 PDE rescues ns2 mu- tant ...central PDE do- main typically localizes to the cytoplasm, or to both the cytoplasm and nuclei, after the N-terminal NLS is deleted ...
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Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV
... another PDE isozyme, PDE-IV, suppresses superoxide generation in glomeruli (Chini, ...tive PDE-III antagonist, lixazinone (LX), together with the specific PDE-IV antagonist, rolipram (RP), can ...
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Synthesis, Anticancer, Anti Tumor, Anti Diabetic and Anti Asthmatic Screening of Some Novel Clubbed Tetrazole Moiety Compounds
... against PDE-IV for potential anti-asthmatic effect, and against DPP-IV and PTP1B for potential anti- diabetic ...using phosphodiesterase IV enzyme (PDE-IV)[22](Table-5) and the primary screening of ...
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Phosphodiesitrase activity of some Egyptian snake venoms: biochemical and immunological characteristics and effect on blood coagulation of phosphodiesterase enzyme from Naja nigricollis venom
... of phosphodiesterase was expressed in nmol of p- nitrophenol/min/mg lyophilized ...of PDE is defined as the amount of the enzyme that hydrolyzes 1 nmole of bis (p-nitrophenyl) phosphate per min under the ...
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Ocimum gratissimum Linn Leaves reduce the key enzymes activities relevant to erectile dysfunction in isolated penile and testicular tissues of rats
... the phosphodiesterase-5 enzyme in diverse parts of corpus cavernosum [5]. PDE-5, an important enzyme of the NO/cGMP signaling pathway, that per- forms a key function in corpus cavernosum weakness, ...
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Cardiovascular Disease Risk Assessment and Treatment of Erectile Dysfunction in Men with Diabetes Mellitus
... Phosphodiesterase 5 inhibitors have been described as the mainstay of oral medical treatment of ED in diabetic patients and include Sildenafil, Vardenafil and Tadalafil [11]. This group of drugs acts by inhibiting ...
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Structural studies on substrate and inhibitor selectivity of phosphodiesterases
... The second messengers cAMP and cGMP mediate the response of cells to a wide variety of hormones and neurotransmitters and modulate many metabolic processes, including cardiac and smooth muscle contraction, ...
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Therapeutic strategies to address neuronal nitric oxide synthase deficiency and the loss of nitric oxide bioavailability in Duchenne Muscular Dystrophy.
... administration, phosphodiesterase (PDE) inhibition and nitrate supplementation, with a focus on the effects on the architecture, function and metabolism of dystrophin-deficient skeletal ...
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Advanced Mobiflage for PDE Enabled Storage
... encryption, PDE can be simplified as follows: different reasonable and innocuous plaintexts may be output from a given ciphertext, when decrypted under different decoy ...a PDE-enabled storage ...
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Sequential Programming for PDE Constrained Optimizations
... The plan of the presentation is as follows. In Chapter 2 we present the basic optimization theory for constrained and unconstrained optimizations. We discuss the existence of optimizers (Section 2.2.1) and formulate the ...
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Construction Solutions of PDE in Parametric Form
... The article contains several interesting solutions and whole classes of solutions for nonlinear differential equations with partial secondary derivatives PDE important in applications. Sometimes in the theory of ...
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True Navier–Stokes Vector PDE
... Abstract The additional equalities (additional differential equations) for the Navier – Stokes and other vector PDE are established in this paper. These equations are obligatory requirements (properties) of three ...
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Limit of the Solution of a PDE in the Degenerate Case
... Pardoux, “Homogenization of Linear and Semilinear Second Order Parabolic PDEs with Periodic Coefficients: A Probabilistic Approch,” Journal of Functional Analysis, Vol.. Pardoux, “BSDEs,[r] ...
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Particles and biomembranes : a variational PDE approach
... The right hand side of this equation is a delta function or a linear combination of delta functions, resulting from the point forces applied to the membrane. We also consider a similar minimisation problem involving ...
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