PDGF-B
Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma
... In summary, the data presented here show that mouse BSG and a subset of human BSG highly express Pax3, dis- tinguishing these tumors from gliomas arising in the cere- bral cortex. This expression pattern of Pax3 is ...
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XPD suppresses cell proliferation and migration via miR-29a-3p-Mdm2/PDGF-B axis in HCC
... and PDGF-B (1:1000; Abcam, Cambridge, UK), furthermore, it was incubated for 2 h with horseradish peroxidase (HRP) conjugated secondary antibodies at room temper- ature and the ECL kit was used to detect ...
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Excessive activation of the TLR9/TGF β1/PDGF B pathway in the peripheral blood of patients with systemic lupus erythematosus
... anti-human PDGF-B (homodimer) polyclonal antibody (R&D Systems) and isotype control antibody (R&D Sys- tems) were added into the culture at a final concentra- tion of 1 or 10 μg/ml; detailed ...
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Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation
... and PDGF-B ...Besides, PDGF-B was screened out by transcriptome sequencing, and angiogenesis was greatly inhibited by PDGF-B knock- ...the PDGF-B expression level ...
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Endothelial and nonendothelial sources of PDGF B regulate pericyte recruitment and influence vascular pattern formation in tumors
... of PDGF-B and PDGF-Rb in pericyte recruitment in a mouse fibrosarcoma ...into PDGF-B retention motif–deficient (pdgf-b ret/ret ) mice, pericytes were fewer and were ...
11
Original Article Effects of low-molecular-weight heparin on lung and pulmonary artery injuries in acute pulmonary embolism rat model via platelet-derived growth factor-B
... assess PDGF-B expression at various time ...RVP. PDGF-B expression were decreased in the LMWH group at all time points compared with the sham and APE groups (P < ...Decreased ...
8
Investigation of VEGF and PDGF signals in vascular formation by 3D culture models using mouse ES cells
... in PDGF B showed immunoreactivities of either Eph B2 (an arterial marker) or Flt4 (a lymphatic ...in PDGF B (Figure ...the PDGF B group, the mRNA of Vegf a was higher in the ...
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Cold shock proteins: from cellular mechanisms to pathophysiology and disease
... For inflammatory and fibrotic diseases, the data for the role of cold shock proteins appears more associative. The initial data came from animal studies on Ybx1 heterozy- gous mice, which express only half the amount of ...
14
Growth factors in periodontal regeneration: A review
... while PDGF-B appears later (Green et ...of PDGF are mainly initiated via two tyrosine kinase receptors termed alpha and beta PDGF receptors (Rosenkranz and kazlauskas 1999) which are ...
6
β-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer
... of PDGF/Src signaling predicts poor clinical outcome in pancreatic cancer ...of PDGF-B and p-Src in pancreatic tumor ...Serum PDGF level (Mean ± ...tumor PDGF/p-Src (+/+) was determined ...
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Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling
... anti-human PDGF-B IgG (Thermo Scientific; Rockford, IL) which cross reacts with mouse PDGF-B overnight at ...visualize PDGF-B/PDGFRb interac- ...
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Growth factor expression in aorta of normotensive and hypertensive rats
... (PDGF) B chain and PDGF A chain, insulin-like growth factor (IGF)-I and IGF-II, endothelial cell growth factor (ECGF), basic fibroblast growth factor (bFGF), and transforming growth factor- beta ...
6
Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation
... homozygous mutant kidneys are reduced in size. These lesions are accompanied by local up-regulation of PDGF-B and TGF-beta1 mRNA in the cortex and down-regulation of PDGF-A mRNA in the papilla. The ...
9
EXPRESSION AND PARTIAL PURIFICATION OF RECOMBINANT PDGF-BB EXPRESSED IN E.COLI
... Refolded PDGF-B Protein samples were transferred from SDS- PAGE gel onto PVDF membrane and western blotting was proceeded as per the standard protocol using 1 0 antibodies raised against PGDF in rabbit and ...
9
Recombinant platelet derived growth factor B gene expression in porcine arteries induce intimal hyperplasia in vivo
... in PDGF B gene transfected arteries compared with control transfected arteries (P = ...recombinant PDGF B gene in vivo can play a role in the induction of intimal hyperplasia, which can lead ...
9
Regional expression of the platelet derived growth factor and its receptors in a primate graft model of vessel wall assembly
... express PDGF mRNA in the ...contain PDGF-like mitogenic ...the PDGF protein isoforms and their receptors in this prosthetic graft ...both PDGF-A and PDGF-B were identified in ...
12
Human keratinocytes are a major source of cutaneous platelet derived growth factor
... of PDGF in human dermal wound repair, the production of PDGF by human keratinocytes has not yet been ...of PDGF by cultured human keratinocytes. Both PDGF A and B chain mRNA can be ...
9
Intracellular signaling pathways required for rat vascular smooth muscle cell migration Interactions between basic fibroblast growth factor and platelet derived growth factor
... (CamKinase II), an intracellular event that we have previously shown to be important in the regulation of VSMC migration. Neutralizing antibodies to bFGF caused a dramatic reduction in the size of the intracellular ...
12
Productive Interaction between Transmembrane Mutants of the Bovine Papillomavirus E5 Protein and the Platelet-Derived Growth Factor β Receptor
... for PDGF  -receptor activation was based primarily on the examination of tyrosine phosphorylation of the precursor form of the PDGF  receptor (1, ...more PDGF  receptor was immunoprecipitated by ...
6
Applications of Quantitative Live-cell Microscopy to Study Intracellular Signaling Dynamics.
... Our substrate model successfully predicted, at least qualitatively, the outcome of this experiment with no additional parameter fitting. The stimulation factor (S) in the model was varied as a proxy for PDGF dose, ...
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