PDGF-R, PDGF receptor
Coexpression of platelet derived growth factor (PDGF) and PDGF receptor genes by primary human astrocytomas may contribute to their development and maintenance
... two PDGF genes (c-sis/PDGF-2 and PDGF-1) and the PDGF-receptor b gene (PDGF-R) in 34 primary human ...the PDGF-R gene in all astrocytomas ...the ...
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Systematic Analysis of Crosstalk in the PDGF Receptor Signal Transduction Network
... Figure 3.7. Computational modeling and analysis of the PDGF receptor signaling network. a. Minimal conceptual model of the network with crosstalk interactions from PI3K lipid products (3’ PIs) affecting ...
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Kinetic Analysis of PDGF Receptor Signaling Pathways in Fibroblasts
... maximal PDGF stimulation in Fibroblast (data not ...relative R 1/ 2 * values of ...a PDGF receptor to GEF activity, Ras-GTP is much more concentrated in the vicinity of the receptor ...
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An activating mutation in the PDGF receptor beta causes abnormal morphology in the mouse placenta
... of PDGF-BB ...the receptor was only phosphorylated in the presence of ligand ...the receptor and pro- liferation of cells even in the absence of ...total receptor phosphorylation and ...
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Integration of Soluble and Adhesive Signals During Fibroblast Migration
... of PDGF through specific, receptor tyrosine kinases while integrins mediate attachment to ...Ligated PDGF receptors are potent activators of phosphoinositide (PI) 3-kinase (PI3K) at the plasma ...
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Coagulation factor Xa stimulates platelet derived growth factor release and mitogenesis in cultured vascular smooth muscle cells of rat
... the PDGF receptor tyrosine kinase pathway since the pathway’s components, Ras, Raf-1, MAPK (both 42 and 44 kD), and the transcription factors, c-Fos and c-Jun, were ...of PDGF did not affect the ...
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Roles of PDGF in animal development
... receptors, PDGF receptor alpha and PDGF receptor beta (Pdgfra, Pdgfrb), have been knocked out in the ...the receptor cytoplasmic domains have been mutated to ...of receptor ...
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Original Article PDGF-Rb and microRNA-329 are associated with endometrial dysfunctionvia targeting CD146
... the PDGF receptors PDGF-Ra and PDGF-Rb, and the level of PDGF- Rb was significantly higher than PDGF-Ra in ESCs and endothelial ...Importantly, PDGF-Ra and PDGF-Rb were ...
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Growth factors in periodontal regeneration: A review
... while PDGF-B appears later (Green et al., 1997). The biologic effects of PDGF are mainly initiated via two tyrosine kinase receptors termed alpha and beta PDGF receptors (Rosenkranz and kazlauskas ...
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Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation
... tumoral PDGF-B’s effect on the vascular maturity has become controversial ...as PDGF receptor β (PDGFR-β), to induce the cell survival, proliferation and migration ...endothelial PDGF-B ...
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Expression of platelet derived growth factor (PDGF) related transcripts and synthesis of biologically active PDGF like proteins by human malignant epithelial cell lines
... both PDGF-1 and PDGF-2 genes. The levels of both PDGF-1 and PDGF-2 transcripts were superinduced when these cells were treated with cycloheximide, an inhibitor of protein ...125I-labeled ...
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Regional expression of the platelet derived growth factor and its receptors in a primate graft model of vessel wall assembly
... express PDGF mRNA in the ...contain PDGF-like mitogenic ...the PDGF protein isoforms and their receptors in this prosthetic graft ...both PDGF-A and PDGF-B were identified in ...
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Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats
... with receptor tyrosine kinase to regulate multiple signal- ing pathways linked with cellular development and di- verse pathological processes ...of receptor protein tyrosine kinase of PDGF ...
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Ribozyme mediated gene knock down strategy to dissect the consequences of PDGF stimulation in vascular smooth muscle cells
... by PDGF-BB on both pro- ...different PDGF receptors. It is well-known that PDGF-BB binds both structurally similar protein- tyrosine kinase receptor subunits (PDGFR-α and PDGFR-β) and that ...
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Human keratinocytes are a major source of cutaneous platelet derived growth factor
... that PDGF does not play an autocrine role in keratinocyte ...for PDGF showed that both PDGF A and B chain is constitutively expressed in normal epidermis, as well as in newly reconstituted wound ...
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Productive Interaction between Transmembrane Mutants of the Bovine Papillomavirus E5 Protein and the Platelet-Derived Growth Factor β Receptor
... the PDGF  receptor within 1 day ...of PDGF  -receptor tyrosine phosphoryla- tion ...of PDGF  -receptor tyrosine ...the PDGF  receptor and morphological ...
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Endothelial and nonendothelial sources of PDGF B regulate pericyte recruitment and influence vascular pattern formation in tumors
... multiple receptor tyro- sine kinases (RTKs) may exert their antitumor activity in part by reducing pericyte density in the tumor vessels, thereby sensitizing them to inhibition of endothelial RTKs ...
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PDGF upregulates CLEC-2 to induce T regulatory cells
... demonstrate PDGF inhibited the maturation of human DCs and induced IL-10 ...of PDGF-DCs with T cells induced the polarization of T cells towards FoxP3 expressing T regulatory cells that secreted ...that ...
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Tissue localization of beta receptors for platelet derived growth factor and platelet derived growth factor B chain during wound repair in humans
... of PDGF beta receptor protein and PDGF-AB/BB were analyzed in wound margin biopsies using the PDGFR-B2 and PDGF 007 ...antibodies. PDGF beta receptor expression was minor in ...
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Antiproliferative Activity of Acerogenin C, a Macrocyclicdiarylheptanoid, on PDGF Induced Human Aortic Smooth Muscle Cells Proliferation
... ng/mL PDGF-BB. As shown in Figure 3, PDGF-BB markedly increased phosphorylation levels on the PDGF-Rβ but acerogenin C treatment had no sig- nificant ...of PDGF-BB, we determined the ...
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