PDGF receptor
Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor α expression
... detect PDGF receptor ␣ expression in the mutant oligodendrocyte precursors, arguing that PDGF receptor ␣ is under transcriptional control of Sox9 and ...Altered PDGF receptor ␣ ...
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Systematic Analysis of Crosstalk in the PDGF Receptor Signal Transduction Network
... Figure 3.7. Computational modeling and analysis of the PDGF receptor signaling network. a. Minimal conceptual model of the network with crosstalk interactions from PI3K lipid products (3’ PIs) affecting ...
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Kinetic Analysis of PDGF Receptor Signaling Pathways in Fibroblasts
... maximal PDGF stimulation in Fibroblast (data not ...a PDGF receptor to GEF activity, Ras-GTP is much more concentrated in the vicinity of the receptor compared to the ...
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Coexpression of platelet derived growth factor (PDGF) and PDGF receptor genes by primary human astrocytomas may contribute to their development and maintenance
... two PDGF genes (c-sis/PDGF-2 and PDGF-1) and the PDGF-receptor b gene (PDGF-R) in 34 primary human ...the PDGF-R gene in all astrocytomas ...the PDGF-1 ...two ...
11
An activating mutation in the PDGF receptor beta causes abnormal morphology in the mouse placenta
... mutant receptor but not in the wild-type or D849N mutant receptor under non-stimulating conditions ...of PDGF-BB, as expected (Fig. 2C). A strict dependence on PDGF-BB for cellular ...
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Essential role for PDGF signaling in ophthalmic trigeminal placode induction
... for PDGF signaling in opV trigeminal placode formation using an alternative ...(dn) PDGF receptor β that was truncated and thus bound the ligand but failed to ...
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Roles of PDGF in animal development
... receptors, PDGF receptor alpha and PDGF receptor beta (Pdgfra, Pdgfrb), have been knocked out in the ...the receptor cytoplasmic domains have been mutated to ...of receptor ...
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Targeting the PDGF signaling pathway in tumor treatment
... The PDGF receptor genes have also been found to be mutated in certain ...the receptor causing activation of the kinase ...related receptor Kit, is even more common. PDGF receptor ...
18
PDGF signaling in pulmonary arterial hypertension
... As PDGF has been implicated in these processes, Schermuly et ...altered PDGF signaling may be involved in the vascular remodeling observed in ...the PDGF receptor inhibitor STI571 in 2 ...
5
FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway
... (PDGF)/PDGF receptor (PDGFR) signaling pathway promotes breast cancer tumorigenesis, but the mechanisms for its dysregulation in breast cancer are largely ...identified PDGF-A as a novel ...
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A role for PDGF signaling in expansion of the extra embryonic endoderm lineage of the mouse blastocyst
... the supplementary material) or in embryos prior to the 16-cell stage (Plusa et al., 2008). Alternatively, PDGFR, the second member of the PDGF receptor family, could be expressed during this period. Pdgfrb ...
12
Review Article PDGF signaling in cancer progression
... against PDGF or PDGFR have gradually been used to test whether they can delay and improve tumor ...human PDGF receptor α (PDGFRα) with high affinity and blocks PDGF ligand binding and PDGFRα ...
12
PDGF/PDGFR effects in osteosarcoma and the “add-on” strategy
... cognate receptor, and osteosarcomas meet these criteria ...of PDGF and PDGFRs has been confirmed in osteosarcoma cell lines, as well as in human osteosarcoma samples, as mentioned ...for PDGF/PDGFR ...
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Reversal of experimental pulmonary hypertension by PDGF inhibition
... the PDGF receptor was found to be significantly increased in lung tissue from pulmonary arterial hypertension patients compared with healthy donor lung ...
12
Original Article Xanthohumol inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppression of PDGF signaling pathway
... of PDGF receptor (PDGF-R) β, AKT and ERK1/2 in PDGF-BB-stimulated ...inhibits PDGF-BB-induced HASMC proliferation and migration through suppression of PDGF signaling ...
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Expression of platelet derived growth factor (PDGF) related transcripts and synthesis of biologically active PDGF like proteins by human malignant epithelial cell lines
... both PDGF-1 and PDGF-2 genes. The levels of both PDGF-1 and PDGF-2 transcripts were superinduced when these cells were treated with cycloheximide, an inhibitor of protein ...125I-labeled ...
9
PDGF upregulates CLEC-2 to induce T regulatory cells
... releases PDGF which not only causes platelet aggregation and angiogenesis but also induces tolerance in DCs via induction of ...CLEC-2. PDGF is also known to upregulate the expression of CLEC-2 on ...
12
A differential role for CD248 (Endosialin) in PDGF-mediated skeletal muscle angiogenesis
... that PDGF signalling can occur normally in the absence of CD248 in most situations, and in cells where CD248 is not expressed (such as endothelial cells ...the PDGF-B or PDGFRb knockout mice, both of which ...
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EXPRESSION AND PARTIAL PURIFICATION OF RECOMBINANT PDGF-BB EXPRESSED IN E.COLI
... Platelet Derived Growth Factor (PDGF) is a 24.3 kDa disulfide linked homodimer of two B chains, 218 total amino acids (2) potent mitogen for a wide range of cell types including fibroblasts, smooth muscle and ...
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Safety and tolerability of intracerebroventricular PDGF BB in Parkinson’s disease patients
... of PDGF-BB seen in preclinical models led us to evaluate PDGF-BB as a potential novel therapy for patients with ...human PDGF-BB (rhPDGF-BB) for ...
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