Peginterferon alfa-2a
Cost-effectiveness analysis of treatment with peginterferon-alfa-2a versus peginterferon-alfa-2b for patients with chronic hepatitis C under the public payer perspective in Brazil
... The objective of this analysis was to compare treatment costs and outcomes of pegylated interferon-alfa-2a versus pegylated interferon-alfa-2b, both associated with ribavirin, in the therapeutic ...
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Evaluation of pharmacokinetics, user handling, and tolerability of peginterferon alfa-2a (40 kDa) delivered via a disposable autoinjector device
... of peginterferon alfa-2a when administered via an ...of peginterferon alfa-2a in healthy ...following peginterferon alfa-2a autoinjector administration were: ...
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Comparison of peginterferon alfa-2a and alfa-2b for treatment of patients with chronic hepatitis C:a retrospective study using the Japanese Interferon Database
... PEG-IFN alfa-2a and alfa-2b, using a t-test for age, the Wilcoxon rank-sum test for duration of therapy, the Mantel–Haenszel chi-square statistic for genotype, and the chi-square test for the other ...
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Serum hepatitis B virus RNA levels as a predictor of HBeAg seroconversion during treatment with peginterferon alfa 2a
... RNA and covalently closed circular DNA (cccDNA) [34 – 36]. CccDNA reflects the number of hepatocytes in- fected with the virus and acts as a template for tran- scription of viral genes [37 – 39]. The ongoing presence of ...
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Long term effects of peginterferon alfa 2a therapy in Japanese patients with chronic hepatitis B virus infection
... PEG-IFN alfa-2a at 180 μg for 48 weeks was the most efficacious and beneficial treatment regimen for HBeAg-positive patients predominantly infected with genotypes B or C, compared with lower doses and ...
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A prospective Study on Adverse Drug Reactions from Pegylated Interferon Alfa-2a and Alfa-2b in Combination with Ribavirin in Hepatitis B and C
... of peginterferon alfa-2a and ribavirin have been reported ...with peginterferon alfa-2a and ribavirin, peginterferon alfa-2a and placebo, or standard ...
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Treatment emergent depression and anxiety between peginterferon alpha 2a versus alpha 2b plus ribavirin for chronic hepatitis C
... are peginterferon alfa-2a (PegIFN-α-2a) and peginterferon alfa-2b (PegIFN-α-2b), which differ in their pharmaco- kinetics and chemical properties; both are cost-effective and ...
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Warfarin and boceprevir interaction causing subtherapeutic international normalized ratio: a case report
... He underwent a transjugular liver biopsy in April 2012 due to possible cirrhosis and for guidance of possible HCV treatment. The biopsy showed mild fatty infiltration of his liver and received a grade of stage F4 with ...
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Pharmacogenetics of hepatitis C: transition from interferon-based therapies to direct-acting antiviral agents
... PEGylated interferon alpha-2b plus ribavirin in patients with genotype 4 chronic hepatitis C: the role of rapid and early virologic response. Peginterferon alfa-2a an[r] ...
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The effectiveness of retreatment with peginterferon alfa and ribavirin in patients with chronic viral hepatitis C genotype 2 and 3: a prospective cohort study in Brazil
... IFN- 2a: Interferon alfa-2a; IFN-2b: Interferon alfa-2b; PCR: Polymerase Chain Reaction; PEG-IFN 2a: Peginterferon alfa-2a; PEG-IFN 2b: Peginterferon ...
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Safety and Efficacy of Pegylated Interferon Alfa-2a for the Treatment of Hepatitis C in Patients with Major Thalassemia
... 3 Peginterferon treatment has been shown to be more effective than conventional interferon as an antiviral agent in non- thalassemic ...about peginterferon treatment in polytransfused patients with chronic ...
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Pegylated interferon alfa 2a monotherapy in patients infected with HCV genotype 2 and importance of rapid virological response
... genotype 2, especially those who become negative for HCV RNA by week 4 of treatment. On the other hand, RBV combination therapy should be considered in those whose HCV RNA becomes seropositive by week 4 of treatment. Our ...
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Predictors of Complete Early Virological Response to Pegylated Interferon and Ribavirin in Egyptian Patients with Chronic Hepatitis C Genotype 4
... We studied retrospectively the data of 1861 Egyptian patients with chronic hepatitis C who received antiviral therapy (pegylated-interferon alpha plus Ribavirin) at Cairo-Fatemic Hospital, Ministry of Health and Popula- ...
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Short versus standard treatment with pegylated interferon alfa-2A plus ribavirin in patients with hepatitis C virus genotype 2 or 3: the cleo trial
... In conclusion, our findings suggest that patients with HCV infection with genotype 2 or 3 who have undetect- able HCV-RNA levels after 4 weeks of treatment with PEG-IFN-a-2a and ribavirin may achieve high ...
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<p>Danoprevir for the Treatment of Hepatitis C Virus Infection: Design, Development, and Place in Therapy</p>
... plus peginterferon alpha-2a and ribavirin offered ...of peginterferon alpha-2a and ribavirin in the danoprevir-based ...with peginterferon alpha-2a and ribavirin, thereby driving ...
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Sustained virological response and its treatment predictors in hepatitis C virus genotype 4 compared to genotypes 1, 2, and 3: a meta analysis
... A randomized trial of 24 versus 48 weeks of peginterferon alpha-2a plus ribavirin in Egyptian patients with hepatitis C virus genotype 4 and rapid viral response.. El Makhzangy H, Esmat [r] ...
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HAEMATOLOGICAL EFFECTS AND SAFETY BEHAVIOUR OF 20 kDa PEGINTERFERON ALPHA-2A (UNIPEG®) IN HEALTHY HUMAN SUBJECTS
... Change in PEG chains (either linear or branched) attached to the protein molecule; results in pegylated interferons (IFN-alpha-2a) with different chemical properties, molecular weight, pharmacokinetic and ...
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Sustained serological and complete responses in HBeAg-positive patients treated with Peginterferon alfa-2b: a 6-year long-term follow-up of a multicenter, randomized, controlled trial in China
... response, respectively, at the end of follow-up [21]. Okanoue et al. (2016) showed that patients with CHB infection (N = 137) sustained a good response (normal ATL levels and low-level of hepatitis B virus) five years ...
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Simeprevir with pegylated interferon alfa 2a plus ribavirin for treatment of hepatitis C virus genotype 1 in patients with HIV: a meta analysis and historical comparison
... Treatment recommendations for chronic hepatitis C have changed dramatically during the last few years, based on the availability of new direct acting antiviral agents such as telaprevir, boceprevir, simeprevir, ...
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An evidence-based review of the potential benefits of taliglucerase alfa in the treatment of patients with Gaucher disease
... Taliglucerase alfa is not yet an authorized treatment for Gaucher ...taliglucerase alfa, and market- ing applications for taliglucerase alfa have been filed in the United States, Europe, Israel, ...
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