Pegylated interferon alfa-2a
Quantification of serum hepatitis B surface antigen in predicting the response of pegylated interferon alfa 2a in HBeAg positive chronic hepatitis B with prior lamivudine exposure
... received pegylated interferon alfa-2a for recurring antiviral therapy were screened in this study, all of them were followed up at the Digestion Department of Chengdu Military General Hospital ...
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A prospective Study on Adverse Drug Reactions from Pegylated Interferon Alfa-2a and Alfa-2b in Combination with Ribavirin in Hepatitis B and C
... is pegylated interferon (peg interferon) and ribavirin for 24 or 48 ...Two pegylated formulations was studied in the present study for the treatment of hepatitis C: PEG-IFN-α 2a, with a ...
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Short versus standard treatment with pegylated interferon alfa-2A plus ribavirin in patients with hepatitis C virus genotype 2 or 3: the cleo trial
... Our study confirmed the hypothesis that in patients with HCV genotype 2 or 3, a strategy of variable-dura- tion treatment with PEG-IFN- a -2a and ribavirin achieves rates of SVR similar to those achieved with ...
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Simeprevir with pegylated interferon alfa 2a plus ribavirin for treatment of hepatitis C virus genotype 1 in patients with HIV: a meta analysis and historical comparison
... methodological limitations have to be considered. One major limitation is that every historical comparison is subject to potential biases that do not exist for random- ized head-to-head comparisons. The evidence from ...
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Pegylated interferon alfa 2a monotherapy in patients infected with HCV genotype 2 and importance of rapid virological response
... of pegylated-interferon (PEG- IFN) and ribavirin (RBV) for 48 weeks, and this treat- ment results in ~50% sustained virological response (SVR) in patients with HCV genotype 1 and high viral loads ...
6
Safety and Efficacy of Pegylated Interferon Alfa-2a for the Treatment of Hepatitis C in Patients with Major Thalassemia
... previous interferon monotherapy, and 12 subjects (23%) were non-responder to previous combination therapy with ...2,type 2a: 2, type 3a: 19, and type 3b: 1) were found in 30 (51%) ...
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Pharmacokinetics comparison of two pegylated interferon alfa formulations in healthy volunteers
... BIP48: Pegylated interferon alfa-2b; CAV: Absorptiometry; CGEB: Center of genetic engineering and biotechnology; CL: Clearance; Cmax: Maximum concentration; CONEP: National research ethics ...
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Cost-effectiveness analysis of treatment with peginterferon-alfa-2a versus peginterferon-alfa-2b for patients with chronic hepatitis C under the public payer perspective in Brazil
... with pegylated interferon alfa-2a or 2b weekly and ribavirin 15 mg/kg daily for 48-72-week treatment ...conventional interferon alfa-2a or 2b, 3 times a week and ribavirin ...
9
Telaprevir-containing regimen for treatment of hepatitis C virus infection in patients with hepatocellular carcinoma awaiting liver transplantation: a case series
... telaprevir, pegylated interferon alfa-2a (PegIFN alfa-2a), and ribavirin in three patients with HCV-associated hepatocellular carcinoma (HCC) awaiting ...(PegIFN ...
6
HDV RNA and HBsAg Evolution during peg IFN Treatment in Three HBV HDV HCV HIV Coinfected Patients
... on pegylated interferon treatment in this setting are limited, with predictive factors for HDV virologic success being un- ...underwent pegylated alfa-2a interferon (peg-IFN) ...
6
Predictors of Complete Early Virological Response to Pegylated Interferon and Ribavirin in Egyptian Patients with Chronic Hepatitis C Genotype 4
... peg interferon alfa-2a/Ribavirin treatment in HCV genotype 1 patients representative of the general chronic hepatitis C population and found that out of the 1550 patients treated with peg ...
6
Comparison of peginterferon alfa-2a and alfa-2b for treatment of patients with chronic hepatitis C:a retrospective study using the Japanese Interferon Database
... Our study also has several limitations. First, there were residual confounders, which could persist due to unmeasured or imprecisely measured potential confounding factors. To adjust for potential confounders, we used ...
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Improved Sustained Virological Response Following Treatment with Pegylated Interferon Alpha 2b Compared with Alpha 2a, Both with Ribavirin, for Chronic Hepatitis C Infection with Genotypes 2 and 3
... Given the limitations of other studies and their associ- ated meta-analyses, the present study, involving over 350 patients in a “real-world” clinical environment extends the literature on this topic. As in the Genotype ...
7
Pegylated interferon alpha 2a and 2b in combination with ribavirin in the treatment of chronic hepatitis C : a systematic review and economic evaluation
... attempt to prevent histological progression, reduce the development of hepatocellular carcinoma and lessen the need for hepatic transplantation. The trial is supported by the US National Institute of Diabetes and ...
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Short-Term Pegylated Interferon α2a Treatment Does Not Significantly Reduce the Viral Reservoir of Simian Immunodeficiency Virus-Infected, Antiretroviral Therapy-Treated Rhesus Macaques
... of pegylated IFN- ␣ 2a (pIFN- ␣ 2a) to reduce the viral reser- voir in simian immunodeficiency virus (SIV)-infected, ART-treated rhesus macaques ...␣ 2a treatment of animals in which virus ...
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IL28B SNP rs12979860 is the Critical Predictor for Sustained Viral Response in Chinese Children Aged 1 to 6 Years with Chronic Hepatitis C
... It is well known that CHC treatment for the hepatitis C patients in childhood can effectively reduce the risk of progression to cirrhosis in their adulthood. However, there remains a dearth of evidence for such ...
6
Original Article Depression scores of delta hepatitis patients treated with pegylated interferon alfa
... Chronic HDV appears to be a long-lasting infec- tion with a relatively high tendency to evolve to cir- rhosis [17]. It is the most severe form of chronic hepatitis and and the only treatment option is interferon-α ...
5
Economic evaluation of pegylated interferon plus ribavirin for treatment of chronic hepatitis C in Thailand: genotype 1 and 6
... Methods: A cost-utility analysis using a model-based economic evaluation was conducted based on a societal perspective. A Markov model was developed to estimate costs and quality-adjusted life years (QALYs) comparing ...
9
Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a Child
... At 4 years of age, because continuous transaminase elevation was observed, PEG-IFN monotherapy was started after obtaining written informed consent from his parents. When the antiviral therapy was started, his serum ...
5
Interferon alfa (pegylated and non pegylated) and ribavirin for the treatment of mild chronic hepatitis C : a systematic review and economic evaluation
... It is assumed, in the watchful waiting strategy, that patients have their initial evaluation and are also assessed for treatment, as it is at this point that they undergo biopsy to stage their liver disease. As all ...
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