pegylated interferon-alpha
Pegylated interferon alpha-2b as adjuvant treatment of Stage III malignant melanoma: an evidence-based review
... defined. Interferon alpha-2b remains to date the most promising approach ...of interferon in its pegylated subcutaneous ...of pegylated interferon alpha-2b in Stage III ...
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Treatment of Hepatitis C with Pegylated Interferon Alpha 2a and Ribavirin: Experience from Benin
... DOI: 10.4236/ojgas.2018.88030 277 Open Journal of Gastroenterology CNHU-HKM in Cotonou. This was a cross-sectional study, retrospective from November 1, 2010 to December 31, 2015 (62 months) and prospective from January ...
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Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a Child
... Copyright © 2012 Takeshi Endo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
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HCV NS5A region and response to pegylated interferon alpha plus ribavirin therapy: mutational analyses in patients with chronic HCV infection
... the alpha helix were found to be ...the alpha helix were found to be ...of alpha helix in NS5A sequence was slightly lesser in consensus sequence as compared to most of the patients’ ...to ...
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Differential expression of interferon induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha
... It is reasonable, therefore, to speculate that IFN treat- ment as well as HCV infection could affect the expres- sion of these miRNAs in the liver more than in the PBMCs. In this regard, it has recently been shown that ...
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Long-term pegylated interferon-α and its potential in the treatment of melanoma
... including interferon- α (IFN- α ) are cytokines used for years in the treatment of solid tumors and hematological ...short. Pegylated forms of IFN- α present an improved pharmacokinetic profi le that ...
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Nanomedicines in the treatment of chronic hepatitis C – focus on pegylated interferon alpha-2a
... PEG chains may be attached at a single or multiple sites on the protein molecule. It is preferable for there to be a single attachment site as excessive pegylation will decrease the activity of the drug (Fung et al 1997; ...
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Changes in peripheral blood lymphocytes in polycythemia vera and essential thrombocythemia patients treated with pegylated-interferon alpha and correlation with JAK2 V617F allelic burden
... high‑dose interferon Alfa‑2b versus cisplatin, vinblastine, and dacarbazine, plus interleukin‑2 and interferon in patients with high‑risk melanoma—an intergroup study of cancer and leukemia Group B, ...
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Improved Sustained Virological Response Following Treatment with Pegylated Interferon Alpha 2b Compared with Alpha 2a, Both with Ribavirin, for Chronic Hepatitis C Infection with Genotypes 2 and 3
... of pegylated interferon α (PEG-IFα) as a part of combination therapy with ribavirin (RBV) is uncertain for patients infected with hepatitis C Genotypes 2 and ...
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The effect of antiviral therapy on hepatitis C virus related thrombocytopenia: a case report
... thrombocytopenic purpura were ruled out. A corticosteroid treatment was started and led to an increase in platelet count. The patient was then treated with pegylated-interferon alpha 2a and ...
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Functional Analysis of Hepatitis C Virus (HCV) Envelope Protein E1 Using a trans-Complementation System Reveals a Dual Role of a Putative Fusion Peptide of E1 in both HCV Entry and Morphogenesis
... For a long time, standard therapy for chronic HCV infection consisted of the administration of pegylated interferon alpha April 2017 Volume 91 Issue 7 e02468-16 Journal of Virology jvi.a[r] ...
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Relationship of TRIM5 and TRIM22 polymorphisms with liver disease and HCV clearance after antiviral therapy in HIV/HCV coinfected patients
... pegIFNα/RBV: pegylated interferon‑alpha plus ribavirin; SVR: sustained virological response; DAAs: direct‑acting antivirals; TRIM: tripartite motif; TRIM5: tripartite motif‑containing 5; TRIM22: ...
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Study on the Presence of HCV RNA in PBMC as Compared with Plasma of Hepatitis C Patients after Treatment
... Also, 25 patients with HCV chronic infection which were positive for anti -HCV ELISA test and HCV- RNA RT-PCR in plasma were selected as positive control group. All patients were treated with Pegylated ...
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Economic evaluation of pegylated interferon plus ribavirin for treatment of chronic hepatitis C in Thailand: genotype 1 and 6
... compare pegylated interferon alpha 2a plus ribavirin and alpha 2b plus ribavirin in CHC genotype 6 patients, the SVR and RVR rate were calculated using the relative risk (RR) in HCV genotype 1 ...
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Influence of insulin resistance on the development of hepatocellular carcinoma after antiviral treatment for non-cirrhotic patients with chronic hepatitis C
... HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma; PEG-IFN α : Pegylated interferon-alpha; SVR: Sustained virological response; AFP: Alpha-fetoprotein; HOMA-IR: Homeostasis model ass[r] ...
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Pharmacogenetics of hepatitis C: transition from interferon-based therapies to direct-acting antiviral agents
... comprising PEGylated interferon-alpha and riba- virin has been the standard of care for patients with chronic hepatitis C for more than a ...augment PEGylated interferon and ribavirin, ...
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Overwhelming Postsplenectomy Infection for Splenectomized HCV Patients
... 2007 Pegylated Interferon Alpha-2b plus Ribavirin in Patients with Genotype 4 Chronic Hepatitis C: The Role of Rapid and Early Virologic Response.. Di Bisceglie, A.M.[r] ...
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Clinical implications of immunecell infiltration in vulvar intraepithelial neoplasia
... The innate immune system acts as the first line of defense against invading viruses. Keratinocytes express pathogen recognition receptors (PRRs), including the membrane bound toll-like receptors (TLR), the cytoplasmic ...
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Effects of Host and virus related factors on Interferon α+ribavirin and Pegylated interferon+ribavirin treatment outcomes in Chronic Hepatitis C patients
... of Interferon (3 Million units per ml) 3 injections per week and Ribavirin 10 mg/day/ kg of the body weight, While 50 patients (second group) received pegylated interferon (PegIFN 80 million units ...
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Rationale and design of a randomized controlled trial of directly observed hepatitis C treatment delivered in methadone clinics
... reducing pegylated interferon from 80% to less than 60% did not have an impact, but reducing ribavirin from 80% to less than 60% was asso- ciated with significant decline in sustained viral response ...
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