PENTOSE-PHOSPHATE PATHWAY
Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated
... creasing experimental support for the idea that other RNA helicases might play important roles in translation initiation, especially where long and complex 5’ UTR structures are encountered (reviewed in Parsyan et al., ...
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ROLES OF BUFFERING CAPACITY AND PENTOSE PHOSPHATE PATHWAY ACTIVITY IN THE GAS GLAND OF THE GULF TOADFISH OPSANUS BETA
... known as the hexose monophosphate shunt), respectively, contributes to gas exchange through pH and salting-out effects on the oxygen-carrying capacity of the blood. Second, a countercurrent multiplier system (i.e. a rete ...
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Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma
... the pentose phosphate pathway (PPP) in human clear cell-renal cell carcinoma (ccRCC) and evaluate the role of these pathways in sustaining cell proliferation, maintenance of NADPH levels, and ...
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Original Article Exosomes mediated pentose phosphate pathway in ovarian cancer metastasis: a proteomics analysis
... KEGG pathway results, we detected pro- teins related to pentose phosphate pathway (PPP), opening a significant key to further research (Table ...
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Vernonia amygdalina simultaneously suppresses gluconeogenesis and potentiates glucose oxidation via the pentose phosphate pathway in streptozotocin induced diabetic rats
... Methods: The chloroform fraction of VA (200 mg/kg and 400 mg/kg body weight) was administered to SDRs for 7 and 14 days. Thereafter, the expression (transcription) of key carbohydrate regulatory genes was evaluated in ...
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A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
... Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of ...
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Enzyme characterisation and kinetic modelling of the pentose phosphate pathway in yeast
... Figure 1: Pictorial representation of the pentose phosphate pathway in Systems Biology Graphical Notation format (SBGN, [Le Nov` ere et al., 2009])), where a circle represents a simple chemical, a ...
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Alterations in Energy/Redox Metabolism Induced by Mitochondrial and Environmental Toxins: A Specific Role for Glucose-6-Phosphate-Dehydrogenase and the Pentose Phosphate Pathway in Paraquat Toxicity
... the pentose phosphate pathway (PPP) ...glucose-6- phosphate, fructose-6-phosphate, glucono-1,5-lactone, and erythrose-4-phosphate were increased by paraquat treatment, which was ...
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Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes
... thesis. Such an outstanding exception is that of inosine-5'- monophosphate dehydrogenase, an essential enzyme in the purine metabolic pathway: it is transcribed too early to allow its translated product to be ...
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The return of metabolism : biochemistry and physiology of the pentose phosphate pathway
... The pentose phosphate pathway (PPP) is associated with several cancer- and cell-proliferation-related signalling ...p53 pathway can stimulate the PPP by inhibiting phosphofructokinase 1 (PFK1) ...
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The N Acetylmuramic Acid 6 Phosphate Phosphatase MupP Completes the Pseudomonas Peptidoglycan Recycling Pathway Leading to Intrinsic Fosfomycin Resistance
... MupP (PP_1764) was identified in this study and characterized as a specific MurNAc 6P phosphatase in P. putida that is required for anabolic PG recycling and intrinsic fosfomycin resistance (Fig. 1). We used fosfomycin ...
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The MEP pathway in Babesia orientalis apicoplast, a potential target for anti babesiosis drug development
... BoDXS is intronless, encoding 667 aa with a predicted size of 77 kDa. BoDXR contains a 184 bp intron because the se- quence obtained from cDNA is shorter than that of gDNA. It is the only intron gene in B. orientalis MEP ...
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The Competing Mechanisms of Phosphate Monoester Dianion Hydrolysis
... alyze phosphate hydrolysis with a poor leaving group, this could reasonably occur through either pathway, presumably with different local ...associative pathway would reduce the rate less if the same ...
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Inositol 1,4,5 trisphosphate and inositol 1,3,4,5 tetrakisphosphate are second messenger targets for cardioactive neuropeptides encoded on the FMRFamide gene
... mediated pathway shown in ...inositol phosphate production in the heart and are thought to mediate their physiological effects via an alternative signalling ...
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Pharmacometabolomic study of the human malaria parasite, Plasmodium falciparum: new insights into parasite biology and mode of drug action
... functionality of arginase in converting arginine to ornithine (Williams and Phang, 1982). Also, it has been reported that although RBC contributes to the production of ornithine, it is unlikely it has a significant role ...
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De novo synthesis of purine nucleotides in human peripheral blood leukocytes Excessive activity of the pathway in hypoxanthine guanine phosphoribosyltransferase deficiency
... the pathway of de novo synthesis of purine ...the pathway, either through decreasing the availability of PRPP, a substrate for this enzyme, or through exerting inhibition on this ...inorganic ...
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Original Article Proteomic identification of osteosarcoma-derived exosomes and their activation of pentose phosphate pathway
... Pantose phosphate pathway also play a anti-oxidant role and regulated by many oncogenes and tumor suppressor genes, such as p53, PTEN, CREM, p63, Myc, AKT, AMPK, PI3K , LKB1/AMPK, mTORC1, K-ras and so on ...
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Relationship between the Rate of H+ Transport and Pathways of Glucose Metabolism by Turtle Urinary Bladder
... relationship the metabolic and transport rates were simultaneously measured under several well-defined conditions. When H + transport was inhibited by either the application of an opposing pH gradient or by ...
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A systems biology approach for the identification of target genes for the improvement of itaconic acid production in Aspergillus species
... PP pathway genes in the same group as the itaconic acid pathway genes (group I; Additional file 1: Table S1) suggested that part of the PP pathway enzymes (Figure 1) positively influence the carbon ...
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CONTRIBUTION OF THE PENTOSE PHOSPHATE SHUNT TO THE FORMATION OF CO2 IN SWIMBLADDER TISSUE OF THE EEL
... the pentose phosphate shunt is not returned to glycolysis for conversion to ...the pentose was not returned to glycolysis but was used for anabolic metabolism, such as RNA production and protein ...
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