Peroxiredoxin (PRDX) 4
Role of Peroxiredoxin 1 and Peroxiredoxin 4 in Protection of Respiratory Syncytial Virus-Induced Cysteinyl Oxidation of Nuclear Cytoskeletal Proteins
... cytoplasmic Prdx-1 targeting inhibits induc- ...in Prdx-1- or Prdx-4-silenced A549 ...factor 4 (tax-responsive enhancer element B67); ATP5A1, ATP synthase, H ⫹ transporting, ...
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Peroxiredoxin 4: a multifunctional biomarker worthy of further exploration
... enzyme peroxiredoxin 4 (Prx4) has culminated in the recognition that Prx4 levels are different in blood drawn from the healthy general population and patients with acute or chronic ...
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Peroxiredoxin 4 (PRDX4): Its Critical In Vivo Roles in Animal Models of Metabolic Syndrome Using Our Unique PRDX4 Transgenic Mice
... Peroxiredoxin 4 (PRDX4): Its Critical In Vivo Roles in Animal Models of Metabolic.. Syndrome Using Our Unique PRDX4 Transgenic Mice.[r] ...
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Original Article Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma
... Objectives: Peroxiredoxin 4 (Prx 4) is a newly emerging antioxidant protein that has been studied in several human ...Prx 4 is highly expressed in human lung cancer and is needed for the ...
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The overexpression of peroxiredoxin-4 affects the progression of idiopathic pulmonary fibrosis
... The oxidant–antioxidant imbalance plays an important role in the pathogenesis of IPF [40], and an increased ex- pression of 8-OHdG, a marker of oxidative stress, is observed in the lungs of patients with IPF [41]. The ...
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Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage
... at 4 °C with primary antibodies against Iba-1 (1:1000, Abcam), MyD88 (1:2000, Abcam), p65 (1:1000, Cell Signal- ing Technology), Prx2 (1:5000, Abcam), and TLR4 (1:200, Santa Cruz) in ...
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<p>The Prognosis Of Peroxiredoxin Family In Breast Cancer</p>
... into 4 µm parts on the silanised glass ...using PRDX antibodies (Table 1) for 2 hrs at a temperature of 37°C, followed by washing again using PBS (thrice for 3 mins ...
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Gamma tocotrienol treatment increased peroxiredoxin 4 expression in HepG2 liver cancer cell line
... Differential analysis of 2DE protein maps of HepG2 cells The expression patterns of protein spots from HepG2 cells treated with GTT were compared to untreated con- trol using 2DE image analysis software. Differential ...
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Interaction of peroxiredoxin V with dihydrolipoamide branched chain transacylase E2 (DBT) in mouse kidney under hypoxia
... that Prdx V exerted pro- tective effects in the hypoxic kidney by regulating a var- iety of individual proteins in a protein ...down Prdx V influences the expression of a variety of protein groups ...
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Original Article Peroxiredoxin-1 attenuates hepatic fibrosis by inhibiting TGF-β1/Smad3 and ROS signal pathways
... Billerica, MA). The membranes were immersed in a blocking solution composed of 5% skim milk and TBS-T (0.05% Tween 20, 20 mM Tris-HCl, and 150 mM NaCl (pH 7.6)) for 1 h at room temperature before incubation with the ...
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Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma
... a 4% to 20% gradient sodium dodecyl sulfate (SDS) polyacrylamide gel (PAGE) (GenScript Corp, Piscataway, NJ, USA) and transferred onto polyvi- nylidene difluoride membranes (Millipore, Billerica, MA, ...
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Peroxiredoxin 1 induces inflammatory cytokine response and predicts outcome of cardiogenic shock patients necessitating extracorporeal membrane oxygenation: an observational cohort study and translational approach
... Human peripheral blood mononuclear cells (PBMCs) were isolated from healthy volunteers using BD Vacu- tainer Cell Preparation Tubes. Monocytes were isolated from PBMCs by plastic adherence method [21], and cul- tured in ...
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Increasing extracellular H2O2 produces a bi phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2 buffering capacity is overwhelmed
... eukaryotes, these Prx disul fi des are reduced by the thioredoxin system. However, the sulfenylated peroxidatic cysteines of thior- edoxin-coupled Prx are highly susceptible to further ‘ hyperoxida- tion ’ to ...
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Migrating leukocytes are the source of Peroxiredoxin V during inflammation in the airways
... Experiments were first performed in the alveolar epithelial cell line A549, co-cultured with mouse macrophage cell line RAW264.7, both with and without the presence of serum. Western blot analyses demonstrated that ...
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Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer
... exposed axillary MFP of anesthetized athymic mice. The cells in PRDX6 knockdown groups were inoculated 4 weeks after transfection. Animals were monitored every 2 days for tumor growth and general health. The rate ...
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Peroxiredoxin 1 Is Required for Efficient Transcription and Replication of Measles Virus
... Prdx1 suppression by RNA interference repressed MeV growth. To analyze the role of Prdx1 on the MeV life cycle, the effect of Prdx1 suppression on MeV growth was examined in HEK293 cells expressing a marmoset SLAM ...
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A New Family of Membrane Electron Transporters and Its Substrates, Including a New Cell Envelope Peroxiredoxin, Reveal a Broadened Reductive Capacity of the Oxidative Bacterial Cell Envelope
... C. crescentus ScsC forms a homodimer in a different way from DsbC. The dimeric nature of DsbC is important for its pro- tein disulfide isomerization activity (48–50). To determine whether CcScsC also forms dimers, we ...
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In the present A work on selective breeding aimed at further consolidation of key qualities of the race of Zalaajinst Edren white goats towards increased length and fineness of fibers and upgrading phenotypic characteristics (Dorjbat Yo, 2013) resulted i
... LeTPx1 peroxiredoxin clone, in the effort to understand the intracellular functions of these ...homologous Peroxiredoxin with a unique N-terminal extension which likely codes for a chloroplastic sequence ...
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Proteomic analysis of retinal pigment epithelium cells after exposure to UVA radiation
... including peroxiredoxin-1 (PRDX1), heat-shock protein 27 (Hsp27), protein disulfide-isomerase (PDI), calreticulin (CALR), 78 kDa glucose-regulated protein (GRP78), alpha crystalline B chain, cell division protein ...
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Plasma level of peroxiredoxin 3 in patients with polycystic ovarian syndrome
... The Beta-TC-6 mouse islet cell line was purchased from the Cell Bank of Chinese Academy of Sciences (Shanghai, China) and maintained in Dulbecco’s modified Eagle’s medium containing 15% fetal bovine serum, 100 U/L ...
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