peroxisome proliferator
Interaction between peroxisome proliferator-activated receptor gamma polymorphism and obesity on type 2 diabetes in a Chinese Han population
... Aims: The aim of this study was to investigate the association of four single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptor gamma (PPARG) with type 2 di[r] ...
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Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma
... (Floyd et al. 2008) and curcumin from curcuma (Ejaz et al. 2009) suppressed adipogenesis on 3T3-L1 cell line through several mechanisms including attenuation of peroxisome proliferator-activated receptor c ...
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Activators of peroxisome proliferator activated receptor gamma have depot specific effects on human preadipocyte differentiation
... hanced markedly the differentiation of preadipocytes from SC sites, assessed by all three criteria. The rank order of po- tency of these agents in inducing differentiation matched their ability to activate transcription ...
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Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor δ from Peroxisome proliferator-activated receptor γ in the ob/obmouse
... PPAR δ agonist treated liver contained decreased linoleate and increased linoleate pathway intermediates, γ -linolenate and dihomo- γ -linolenate, and the pathway end product arachidonate (Figure 5b). The ∆ 6-desaturase ...
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Peroxisome proliferator activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin 1β in articular chondrocytes
... IL-1 downregulates PPAR γ 1 expression at the transcriptional level IL-1 downregulates PPAR γ 1 expression at the transcriptional level. (a) Osteoarthritis (OA) chondrocytes were treated with increasing concen- trations ...
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Fenretinide inhibits macrophage inflammatory mediators and controls hypertension in spontaneously hypertensive rats via the peroxisome proliferator-activated receptor gamma pathway
... Abstract: Fenretinide is a novel anticancer agent reported to exhibit anti-invasive and antimetastatic activities. It has also been shown to improve obesity and diabetes, although the effects of fenretinide on ...
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The C161T Polymorphism in Peroxisome Proliferator Activated Receptor ɣ2, but Not Pro12Ala, Is Associated with Diabetic Retinopathy in Type 2 Diabetes Mellitus in an Egyptian Population
... The C161T Polymorphism in Peroxisome Proliferator-Activated Receptor ɣ2, but Not Pro12Ala, Is Associated with Diabetic Retinopathy in Type 2 Diabetes Mellitus in an Egyptian Population R[r] ...
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Haplotype Analysis of Peroxisome Proliferator-activated Recep-tor γ Gene Polymorphisms and the Lipoprotein (a) Level
... years. Peroxisome proliferator-activated receptor (PPAR)γ, the ligand-activated transcription factors, was con- sidered as an indispensable role in the process of lipid ...the peroxisome ...
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Peroxisome Proliferator-Activated Receptors (PPARS): A Target with a Broad Therapeutic Potential for Human Diseases: An Overview
... [69]. Peroxisome proliferator-activated receptor agonist mediated preservation of insulin/IGF responsive neurons was associated with increased expression of ChAT, which has an important role in cognition, ...
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A role for peroxisome proliferator activated receptors in the immunopathology of schistosomiasis?
... The peroxisome proliferator-activated receptors (PPARs) are a group within the 48 transcription factors of the nuclear hormone receptor family involved in lipid metabolism and inflammation ...with ...
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Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity
... The peroxisome proliferator-activated receptors (PPARs) belong to a nuclear receptor (NR) superfamily of ligand- inducible transcription factors that form functional com- plexes with the retinoid × ...
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Genetic studies in type2 diabetes in unani concepts of temperament; association between pro12ala polymorphism of peroxisome proliferator activated receptor gamma 2 (PPAR α) of Indian populati
... RESEARCH ARTICLE GENETIC STUDIES IN TYPE2 DIABETES IN UNANI CONCEPTS OF TEMPERAMENT; ASSOCIATION BETWEEN PRO12ALA POLYMORPHISM OF PEROXISOME PROLIFERATOR PROLIFERATOR-ACTIVATED RECEPTOR-[r] ...
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Selective peroxisome proliferator-activated receptorα modulators (SPPARMα): The next generation of peroxisome proliferator-activated receptor α-agonists
... Dyslipidemia is a major risk factor for cardiovascular (CV) disease – the primary cause of death, worldwide. Although reducing levels of low-density lipoprotein-cholesterol can significantly reduce CV risk, a high level ...
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Original Article The association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene with the metabolic characteristics in Chinese women with polycystic ovary syndrome
... the peroxisome Proliferator-activated receptor-gamma2 PPARγ2) gene that account for metabolic dysfunction in women with polycystic ovary syndrome (PCOS) remain ...
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Gene modulation during peroxisome proliferator-induced hepatocarcinogenesis
... some proliferator-activated receptor α may mediate known, but it is possible that cyclophilin-mediated regulation of PP-induced alterations in mitogenic and/or apoptotic apoptosis is disrupted ...
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Statins, fibrates, thiazolidinediones and resveratrol as adjunctive therapies in sepsis: could mitochondria be a common target?
... Through their pleiotropic actions, statins, fibrates, thiazolidinediones and resveratrol can target multiple mechanisms involved in sepsis. Their actions on mitochondrial function are of interest in a pathological state ...
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Modulation of adipocyte lipogenesis by octanoate: involvement of reactive oxygen species
... pocytes [13,14]. Furthermore, MCFA are recovered in the adipose tissue fatty acids up to 30 mole % in both animals and humans adapted to MCT diets [6,15-17]. These find- ings imply that a substantial influx of MCFA into ...
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Adult-onset type II citrullinemia: Current insights and therapy
... of peroxisome proliferator-activated receptor α suggest that citrin deficiency impairs hepatic de novo lipogenesis coupled with glycolysis leading to the energy deficit of ...
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The Pro12Ala polymorphism in the PPARγ2 gene is not associated with an increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus
... Background: The peroxisome proliferator-activated receptors (PPARs) are ligand- activated transcription factors that belong to the nuclear hormone receptor superfamily. Several studies have demonstrated a ...
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In silico Docking Analysis of Active Biomolecules from Cissus quadrangularis L. against PPARG
... Introduction: Thiazolidinedione’s are widely used synthetic antidiabetic agents. These agents affect the pumping power of heart muscle due to the formation of edema; limiting their usage in patients with congestive heart ...
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