PGC-1α
SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis
... of PGC-1α in HCC specimens, and ectopic expression of SIRT1 increased PGC-1α ...model, PGC-1α overexpression reversed the inhibitory effects of SIRT1 depletion on invasion and ...
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Effect of Eight Weeks Aerobic and Combined Training on Serum Levels of Sirtuin 1 and PGC-1α in Coronary Artery Bypass Graft Patients
... of high-intensity interval training notably increased SIRT1 levels and triggered overexpression of oxidative enzymes, ultimately reducing oxidative stress and enhancing training performance (45). Narou et al. studied the ...
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Original Article Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro
... [11] Benton CR, Holloway GP, Han XX, Yoshida Y, Snook LA, Lally J, Glatz JF, Luiken JJ, Chabowski A, Bonen A. Increased levels of peroxisome proliferator-activated receptor gamma, coacti- vator 1 alpha ...
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The gene coding for PGC-1α modifies age at onset in Huntington's Disease
... coactiavtor 1α (PGC-1α) plays a role in the neurodegeneration of HD ...[11-13]. PGC-1α regulates the expression of mitochondrial OXPHOS genes and endogenous ...of PGC-1α ...
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Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche
... coactivator 1α (PGC-1α) is a major driver of oxidative fiber-type specification, mitochondrial biogenesis, and high endur- ance capacity ...Furthermore, PGC-1α gene expres- sion is ...
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PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein
... of PGC-1α has previously been reported to decrease the expression of dopamin- ergic markers in the adult SN, consistent with downreg- ulation of the transcription factor Pitx3 ...of PGC-1α ...
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Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin
... of PGC-1α or PGC-1β on mdx mice subjected to eccentric physical exercise:- that is, downhill ...mdx/MCK- PGC-1α and mdx/MCK-PGC-1β had significantly lower levels of serum ...
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PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle
... Muscle PGC-1α expression has previously been associ- ated with tissue ...muscle PGC-1α expres- sion in glucose intolerant and type 2 diabetic patients significantly correlates with elevated ...
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Original Article Lack of PGC-1α exacerbates high glucose-induced apoptosis in human umbilical vein endothelial cells through activation of VADC1
... overnight: PGC-1α, Bip/GRP78 (diluted 1:100), VDAC1, VDAC2 and VDAC3 (diluted 1:400) (Santa Cruz, CA, USA); Bcl-2, Bax, cytochrome c, COX IV, cleaved caspase-3 and cleaved cas- pase-9 (1:2000, Cell ...
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Differential regulation of PGC-1α expression in rat liver and skeletal muscle in response to voluntary running
... muscle PGC-1α gene expression ...muscle PGC-1α mRNA expression ...muscle PGC-1α leads to enhanced mitochondrial electron transport activities that enables cells to meet ris- ing ...
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Abnormal glucose homeostasis in skeletal muscle–specific PGC 1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk
... coactivator 1α (PGC-1α) is a strong activator of mitochondrial biogenesis and oxidative ...of PGC-1α and many of its mitochondrial target genes are decreased in the skeletal muscle of ...
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Yiqihuoxue decoction protects against post myocardial infarction injury via activation of cardiomyocytes PGC 1α expression
... [5]. PGC- 1α, a transcriptional coactivator, acts as a master regulator of mitochondrial biogenesis and energy metabolism, and it also decreases oxidative stress [31], and promotes fatty acid oxidation and ...
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Cloning of PGC-1α from Grass Carp and Its Response to Cadmium-Induced Stress
... 2005). PGC-1α, a master regulator of mitochondria function, modulates oxidative phosphorylation and fatty acid oxidation gene expression and has been reported coordinated balancing of muscle oxidative ...
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PGC-1α supports glutamine metabolism in breast cancer
... of PGC-1α on the expression of key genes involved in lipid ...of PGC-1α ...of PGC-1α in glutamine-mediated lipid biosynthesis, we incubated ...that PGC-1α and ERRα ...
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PGC 1α promotes recovery after acute kidney injury during systemic inflammation in mice
... reduced PGC-1α expression and oxygen consumption in response to TNF-α; however, excess PGC-1α reversed the latter ...tubule-specific PGC-1α–knockout mice had normal basal renal ...
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Multiple environmental and genetic factors influence skeletal muscle PGC 1α and PGC 1β gene expression in twins
... coactivator 1α (PGC-1α) and PGC-1β genes in skeletal muscle from type 2 diabetic patients, but it is not known whether this is an inherited or acquired ...the PGC-1α ...muscle ...
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PGC-1α modulates denervation-induced mitophagy in skeletal muscle
... of PGC-1α overexpression on the levels of autophagy genes and proteins basally and in re- sponse to ...that PGC-1α selectively induces the expression of specific autophagy and lysosomal ...
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A20 deubiquitinase controls PGC-1α expression in the adipose tissue
... (TNFAIP3), PGC-1α and PPARγ in the brown, visceral and subcutane- ous adipose tissue (Mm00437121_m1; Mm44718 3 m1; Mm01184322_m1, respectively - Life Technologies, Van Allen Way Carlsbad, CA, USA) and the ...
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Endoplasmic Reticulum Stress Links Hepatitis C Virus RNA Replication to Wild-Type PGC-1α/Liver-Specific PGC-1α Upregulation
... Disparate promoter usage suggests different transcriptional regulation between L-PGC-1␣ and WT-PGC-1␣. The pro- moter study by Felder et al. (11) suggests that forkhead box O1 (FoxO1) plays a greater role ...
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Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease
... Background: Huntington disease (HD) is caused by a polyglutamine expansion of more than 35 units in the huntingtin protein. This expanded repeat length inversely correlates with the age-at-onset (AAO), however, ...
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