pharmacological inhibition
Pharmacological Inhibition of Host Heme Oxygenase 1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes
... that pharmacological inhibition of HO-1 in ...HO-1 inhibition might sup- press pathogen growth is currently ...HO-1 inhibition may lead to diminished bacterial growth by limiting the ...
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Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin
... Nevertheless, pharmacological inhibition of a range of Bcl-2 family members showed that inhibitors targeting Bcl-xL synergistically enhanced the response to the chemotherapeutic agent, ...
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<p>Pharmacological Inhibition of Necroptosis Promotes Human Breast Cancer Cell Proliferation and Metastasis</p>
... Despite the broad involvement of necroptosis signaling in immune response, the detailed role of necroptosis in breast cancer cell proliferation and metastasis remains largely unknown. In the present study, we collected ...
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Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage
... Pharmacological inhibition of sEH increased neuronal viability treated with conditioned medium from thrombin- or hemin-stimulated cultured microglia Since our in vivo results showed that deletion and inhib- ...
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Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer
... Pharmacological inhibition of ABCC3 with MCI-715 inhibits STAT3 signalling and induces PDAC cell apoptosis Considering the remarkable results obtained with ABCC3-targeting approach, the mechanisms of action ...
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Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin
... Nevertheless, pharmacological inhibition of a range of Bcl-2 family members showed that inhibitors targeting Bcl-xL synergistically enhanced the response to the chemotherapeutic agent, ...
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Pharmacological inhibition of EZH2 disrupts the female germline epigenome
... To assess whether growing oocytes could recover after the extensive loss of H3K27me3 resulting from tazeme- tostat treatment, we carried out an in vivo recovery experiment. One cohort of 7-week-old adult female mice were ...
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Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia
... for 15 days. Cell viability in each well was determined and data were analyzed by the program CompuSyn, which calculates the combination index (CI) for each drug com- bination [41]. The combinations with CI <1 ...
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Pharmacological inhibition of the transcription factor PU 1 in leukemia
... To gain structural insight into the mechanism by which the diamidines inhibit PU.1 binding to the λB site, we performed a molecular dynamics simulation of the DB2313-λB complex. The λB-bound complex showed the expected ...
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Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
... Several reports describe the in vitro application of AHL analogs to achieve inhibition of the quorum-sensing cir- cuits of various bacteria (30–34). These studies have gen- erated substantial knowledge about the ...
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Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR −/− mouse model of atherosclerosis
... significant inhibition of PTP1B remained in drug treated cohorts (Supplemental ...of inhibition observed is likely due to drug washout, since single dose and chronic cohorts had 4- and 6-weeks, ...
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Dysregulation of ubiquitin homeostasis and β catenin signaling promote spinal muscular atrophy
... symptoms. Pharmacological or genetic suppression of UBA1 was sufficient to recapitulate an SMA- like neuromuscular pathology in zebrafish, suggesting that UBA1 directly contributes to disease ...cological ...
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Effects of phosphodiesterase 3A modulation on murine cerebral microhemorrhages
... global inhibition of the PDE3A pathway in this model caused an increase in other PDE isoforms that are ubiquitously expressed in the brain [37] as a compensatory mechanism to degrade cAMP [38, ...and ...
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[11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein
... Methods: [ 11 C]Flumazenil PET scans were performed in wild type (WT) (n = 9) and Mdr1a/1b, (the genes that encode for P-gp) double knockout (dKO) (n = 10) mice, and in naive rats (n = 10). In parallel to PET scanning, [ ...
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Itchy channels and where to find them
... or pharmacological inhibition of TRPV1, TRPA1 and other candidate ion channels on the excitation of itch afferent’s peripheral endings in in response to pruritogen application to the ...
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Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5
... To confirm this role for ERK5 in enhancing vomocytosis, we first exposed human macrophages, differentiated from peripheral blood monocytes, to XMD17-109. It has previously been shown that primary human macrophages show ...
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Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation
... contents in liver and skeletal muscle [20-22], also indicates that palmitoleic acid increases glucose uptake in adipo- cytes through different mechanisms of action. In this sense, we have found that palmitoleic acid ...
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Acarbose, lente carbohydrate, and prebiotics promote metabolic health and longevity by stimulating intestinal production of GLP-1
... by pharmacological inhibition of carbohydrate digestion, as with acarbose — can exert a range of favourable effects on health and longevity by up-regulating GLP-1 production and concurrently blunt- ing the ...
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Peters, Finn (2018): Pharmacological BACE1 inhibitor treatment during early progression of β-amyloid pathology maximizes therapeutic efficacy. Dissertation, LMU München: Fakultät für Biologie
... by pharmacological inhibition of BACE1 in adult wild type mice ...whether pharmacological BACE1 inhibition causes a similar phenotype in ...
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Mechanisms whereby extracellular adenosine 3',5' monophosphate inhibits phosphate transport in cultured opossum kidney cells and in rat kidney Physiological implication
... That metabolism of cAMP was a prerequisite to uptake was evidenced by the following: a pharmacological inhibition of phosphodiesterases, either by RO 20-1724 24 or, to a lesser extent, b[r] ...
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