Phase i ii
Safety and hemostatic efficacy of fibrin pad in partial nephrectomy: Results of an open-label Phase I and a randomized, standard-of-care-controlled Phase I/II study
... reported. Phase I/II (N = 7): Hemostatic success at 10 min (primary endpoint) was achieved in 3/4 patients treated with fibrin pad versus 0/3 patients treated with ...
8
Phase I/II clinical trial of enzyme replacement therapy with idursulfase beta in patients with mucopolysaccharidosis II (Hunter Syndrome)
... MPS II suggested that 24 weeks of ERT with idursulfase beta (Hunterase W , Green Cross ...comparator-controlled, phase I/II clinical trial of idursulfase beta designed to evaluate its efficacy ...
8
A qualitative evaluation of volunteers' experiences in a phase I/II HIV vaccine trial in Tanzania
... The HIVIS03 project enrolled 60 volunteers (45 men and 15 women) in the Phase I/II HIV vaccine trial. All volunteers were recruited from the police force and all of them were police officers [11,12]. ...
13
A Phase I/II Evaluation of Stavudine (d4T) in Children With Human Immunodeficiency Virus Infection
... Cross, Victoria L. Rutkiewicz, Howard M. Rosenblatt, I. Celine Hanson and William T. Anne Marianne E. Federici, Mary E. Schultze, Lin Woods, Diane F. Loewen, Sanjeev Kaul, Mark W. Kline, Lisa M. Dunkle, Joseph A. ...
8
A Phase I/II Study of the Protease Inhibitor Indinavir in Children With HIV Infection
... In summary, although indinavir is a potent and generally well-tolerated antiretroviral agent (except for the relatively common occurrence of reversible hematuria and occasional nephrolithiasis at higher doses), the ...
11
Intradermal injection of a Tat Oyi based therapeutic HIV vaccine reduces of 1 5 log copies/mL the HIV RNA rebound median and no HIV DNA rebound following cART interruption in a phase I/II randomized controlled clinical trial
... case scenario”, which were 39 copies for HIV RNA and 19 copies for HIV DNA (respectively 1.6 log and 1.3 log. The non parametric Mann and Whitney test [36] was used as a standard test. All p values are one-sided because ...
11
Combination therapy with histone deacetylase inhibitors (HDACi) for the treatment of cancer: Achieving the full therapeutic potential of HDACi
... reported phase III clinical trial has demonstrated that olaparib monother- apy is significantly superior to physicians choice of chemotherapy in the treatment of metastatic breast cancer (MBC) patients with ...
15
The elements of life and medicines
... in phase II clinical trials for treatment of high-risk osteosarcoma [273] and breast cancer metastatic to bone only [274] as well as phase I/II trials in combination with zoledronic ...
57
Enzalutamide: an evidence-based review of its use in the treatment of prostate cancer
... August 31, 2012 for men with metastatic castration-resistant prostate cancer who have already received prior docetaxel- containing chemotherapy. As a result of this product label, enzalutamide cannot currently be ...
9
PROTEASOME INHIBITORS FOR USE IN MULTIPLE MYELOMA
... EC: Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic ...R: Phase I/II trial assessing bortezomib and melphalan ...
10
Targeted therapy in melanoma
... a phase I/II trial of 35 patients with progressive stage IV melanoma pretreated with no more than three previous chemotherapy ...placebo-controlled phase III trials investigating the addition ...
10
Emerging therapeutic potential of nanoparticles in pancreatic cancer: a systematic review of clinical trials
... nanoparticles, and not involving patients with pancreatic cancer. After appraising 53 full text articles, a further 50 were excluded because they were not clinical trials or involved the diagnosis or investigation of ...
20
Current clinical trials testing the combination of immunotherapy with radiotherapy
... small phase 1/2 ...subsequent phase 2 trial in 33 men with intermediate- to high-risk prostate cancer demonstrated a detectable PSA-specific T-cell re- sponse with vaccination ...a phase 1 trial in ...
20
Characterization of Methicillin Resistant Staphylococcus aureus Strains Recovered from a Phase IV Clinical Trial for Linezolid versus Vancomycin for Treatment of Nosocomial Pneumonia
... screened for heterogeneous resistance to vancomycin (hVISA) by the Etest macromethod. All strains were subjected to Panton- Valentine leukocidin (PVL) screening, and SCCmec, pulsed-field gel electrophoresis (PFGE), and ...
9
Multicenter Laboratory Validation of the BACTEC MGIT 960 Technique for Testing Susceptibilities of Mycobacterium tuberculosis to Classical Second Line Drugs and Newer Antimicrobials
... phases I and II, the PI site selected strains which originated from clinical ...In phase I, susceptible strains, and in phase II, as many resistant strains as possible, were ...
5
An Intelligent Quality of Service Architecture for Information-Centric Vehicular Networking
... The remainder of the paper is arranged as follows. Section II and III will introduce the related work proposed by Wu and Tsai [11] and Khodaei and Faez [19]. Section IV will analyze the FOBP issues of Khodaei and ...
11
Evaluating three decades of the European Capital of Culture programme: a difference in differences approach
... Table 1 displays the estimated effects on GDP per capita for every phase of the programme. These estimates are calculated under specifications (1) and (2), that include the fixed effects and year dummies. The ...
21
Structures, electronic properties and stability phase diagrams for copper(i/ii) bromide surfaces
... exhibit metallic characters. The formalism of the ab initio atomistic thermodynamics affords the construction of energy phase diagrams. We predict the CuBr(001) surface, truncated with Br atoms, to be the most ...
37
Phase shift of cyclotron orbits at type-I and type-II multi-Weyl nodes
... the phase jump of π acquired in the magnetic-breakthrough region and a robust phase shift of nπ induced by the topological ...the phase in the two loops of the breakthrough orbit, which are traversed ...
5
Mapping of pathology curriculum as quadriphasic model in an integrated medical school: how to put into practice?
... basic phase is the gastrointestinal tract ...this phase lies in the harmonization step of the Harden ladder in which the teachers responsible for different courses or different parts of the same course ...
9