Phospholipase A2, PLA2
Computational investigations of physicochemical, pharmacokinetic, toxicological properties and molecular docking of betulinic acid, a constituent of Corypha taliera (Roxb ) with Phospholipase A2 (PLA2)
... Phospholipase A2 (PLA2) hydrolyzes the membrane glycerophospholipids and releases arachidonic acid even- tually leading to the production of pro-inflammatory mediators such as leukotrienes, ...
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In silico and in vitro study of the bromelain-phytochemical complex inhibition of phospholipase A2 (Pla2)
... Abstract: Phospholipase A2 (Pla2) is an enzyme that induces inflammation, making Pla2 activity an effective approach to reduce ...this Pla2 inhibitory activity has important therapeutic ...
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Subcellular characteristics of phospholipase A2 activity in the rat kidney Enhanced cytosolic, mitochondrial, and microsomal phospholipase A2 enzymatic activity after renal ischemia and reperfusion
... Phospholipase A2 (PLA2) activities in cytosolic, mitochondrial, and microsomal fractions of rat kidneys were characterized under control conditions, after ischemia, and subsequent to ischemia and ...
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Anti-inflammatory and antioxidant activity of salicylic acid conjugated dihydropyrazoline analogues
... by phospholipase A2 (PLA2) inhibition and in vitro antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl, nitric oxide, hydroxyl radical scavenging assay and ferrous ion chelating assay wherein ...
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Interferon gamma induces the synthesis and activation of cytosolic phospholipase A2
... of phospholipase A2 (PLA2) in BALB/c 3T3 fibroblasts and a human neuroblastoma cell ...cytosolic phospholipase A2 (cPLA2) in a human bronchial epithelial cell line (BEAS ...the ...
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Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A2 (Lp-PLA2 ): a review
... Aschermann M, Duckers H, Bleie O, Dudek D, Bøtker HE, von Birgelen C, D ’ Amico D, Hutchinson T, Zambanini A, Mastik F, van Es GA, van der Steen AF, Vince DG, Ganz P, Hamm CW, Wijns W, Zalewski A, Integrated Biomarker ...
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Influence of obesity and cardiometabolic makers on lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in adolescents: the healthy young cross-sectional study
... Anti-LDL( − ): Autoantibodies against electronegative low density lipoprotein; Apo AI: Apolipoprotein AI; Apo B: Apolipoprotein B; BMI: Body mass index; HDL: High density lipoprotein; HO[r] ...
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Unusual stability of messenger RNA in snake venom reveals gene expression dynamics of venom replenishment.
... PCR amplification of a range of venom protein transcripts including snake venom metalloproteinases (SVMP), phospholipase A2 (PLA2), serine protease (SP), C-type lectins (CTL), vascular e[r] ...
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Predicting the mechanism of phospholipidosis
... pase A2 (LYPLA2) has previously been linked with phospholipidosis, however, due to the lack of data in ChEMBL it was not present in the ...and phospholipase A2 (PLA2) were present in the model ...
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Phospholipase A2 is involved in galactosylsphingosine induced astrocyte toxicity, neuronal damage and demyelination
... that phospholipase A2 (PLA2) may play a role in psychosine induce cell ...for PLA2 in psychosine-induced cell death of oligodendrocytes and astrocytes, the results show inhibition of ...
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Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, platelet-activating factor acetylhydrolase (PAF-AH) in leukocytes and body composition in healthy adults
... In multiple regression models upper and total adiposity measures were positively associated with Lp-PLA 2 activity in men after adjusting for LDL-cholesterol, age, smoking, hs-CRP and p[r] ...
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Antibacterial properties of chicken intestinal phospholipase A2
... Ch PLA2-IIA added to 10 8 cells of growing culture of gram-positive bacteria: Bacillus cereus (BC), micrococcus luteus (ML), Brevibacterium flavum(BF), Staphylococcus aureus (SA), Staphylococcus epidermis(SEp), ...
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In vitro study of the PLA2 inhibition and antioxidant activities of Aloe vera leaf skin extracts
... IIA phospholipase A2 (hG-IIA) and Me-Indoxam were generous gifts from ...IB phospholipase A2 (pG-IB), Egg yolk phosphatidylcholine or lecithin, red phenol and sodium taurodeoxycholate (NaTDC), ...
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Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis
... of PLA2-driven metab- olism, directly and via cross talk with ...different PLA2 inhibitors that has been used to treat the ...the PLA2 enzymes with elements of antigen-specific ...
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Glucocorticoid deficiency increases phospholipase A2 activity in rats
... total PLA2 activity was higher than that of mRNA or PLA2 protein, suggesting that the activity of the enzyme was modulated by inhibitors or ...of PLA2 enzyme was strongly correlated with the activity ...
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Study of the Activity of Phospholipase A2 in Venom of the Transcaucasian Macrovipera Lebetina Obtusa
... the PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and proteins purified from animal ...have PLA2 inhibitory proteins, called PLIs, in their blood ...against PLA2 ...
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A snake venom phospholipase A2 blocks malaria parasite development in the mosquito midgut by inhibiting ookinete association with the midgut surface
... the PLA2 from Crotalus adamanteus (see ...a PLA2 and its ability to block ookinete adhesion and oocyst ...venom PLA2 has the highest inserting ability measured in any phospholipase (Demel et ...
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Lipoprotein Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome
... Progression to ACS seems to depend most on exaggerated inflammatory changes within atherosclerotic plaques.1-3 In recent studies, lipoprotein-associated phospholipase A2 Lp-PLA2 was foun[r] ...
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IN SILICO VALIDATION OF ANTI-RUSSELL’S VIPER VENOM ACTIVITY IN PHYLLANTHUS EMBLICA L. AND TAMARINDUS INDICA L.
... basic phospholipase A2 VRV-PL-VIIIa, anticoagulant class II phospholipase A2 and Russell's viper venom serine proteinase RVV-V were retrieved from ...basic phospholipase A2 ...
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Venom proteomics and antivenom neutralization for the Chinese eastern Russell’s viper, Daboia siamensis from Guangxi and Taiwan
... siamensis of Taiwan island; KSPI, Kunitz-type serine protease inhibitor; PLA2, phospholipase A2; Snaclec, snake venom C-type lectin/lectin-like protein; SVSP, snake venom serine protease[r] ...
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