photoreceptor degeneration
<p>Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments</p>
... progressive photoreceptor loss and severe visual impairments in the ...photoreceptor degeneration. Typically, MNU toxicity induces massive photoreceptor degeneration in mice ...the ...
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Local photoreceptor degeneration causes local pathophysiological remodeling of retinal neurons
... of photoreceptor degeneration, drug or gene therapy should alter function near the degenerated region while hav- ing few or no side effects on healthy areas of the ...
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Involvement of NT3 and P75NTRin photoreceptor degeneration following selective Müller cell ablation
... The photoreceptor degeneration after Müller cell abla- tion could be due to either reduced NT3/TrkC signaling or enhanced pro-neurotrophin/p75 NTR signaling or both ...attenuates photoreceptor injury ...
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Loss of ift122, a Retrograde Intraflagellar Transport (IFT) Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport
... in photoreceptor cell bodies and induces photoreceptor cell degeneration (20, ...to photoreceptor degeneration, we next observed subcel- lular localization of an IFT-B component, ift88, ...
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Rescue from Photoreceptor Degeneration in therd Mouse by Human Immunodeficiency Virus Vector-Mediated Gene Transfer
... receptor degeneration until up to 6 weeks after birth (4, ...authentic photoreceptor cells detected by anti-opsin ...more photoreceptor cells survived at earlier time points as others have reported ...
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Establishment of monocular-limited photoreceptor degeneration models in rabbits
... of photoreceptor degeneration in a rabbit model: verteporfin with light exposure and ...model, photoreceptor degeneration can be limited to the area exposed to ...local photoreceptor ...
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Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration
... The Arrestin-1 knockout mouse (Arr1 −/− aka Sag −/− ) [18] allows the natural immune response to cell-autonomous neurodegeneration to be readily controlled and studied over time. Arrestin-1, also known as S-antigen or ...
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Koch, Mirja Annika (2016): The role of impaired cGMP homeostasis in cone photoreceptor degeneration. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... rod photoreceptor-specific expression and a 2A-eGFP cassette into an AAV vector plasmid (Figure ...the photoreceptor layer of the cA-cGK-injected eye was completely lost (Figure ...
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mTOR mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice
... Retinal pigment epithelial (RPE) cell dysfunction plays a central role in various retinal degenerative diseases, but knowledge is limited regarding the pathways responsible for adult RPE stress responses in vivo. RPE ...
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Microglia are not required for prion-induced retinal photoreceptor degeneration
... PR degeneration diseases in ...PR degeneration by secretion of chemotactic and inflamma- tory cytokines, generation of reactive oxygen and nitro- gen species, and by aberrant phagocytosis of living PR cells ...
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Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization associated oxidative stress
... vascular abnormalities was associated with an increased presence of markers associated with oxidative stress. Oral antioxidant supplementation protected against photoreceptor degeneration and preserved ...
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Fundus wide subretinal and pigment epithelial abnormalities in macular telangiectasia type 2
... macular degeneration, for instance, it has been suggested that inef fi cient outer segment phagocy- tosis may cause a build-up of photo-oxidized products or other toxic by-products, leading to RPE cell death and ...
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Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration
... chronic photoreceptor degeneration in rds (retinal degeneration slow) mice [38], and photoreceptor apoptosis in vitro ...retinal degeneration, the precise signaling events that mediate ...
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Light induced degeneration and microglial response in the retina of an epibenthonic pigmented teleost: age dependent photoreceptor susceptibility to cell death
... the photoreceptor cell layer of larval and juvenile individuals (Bejarano- Escobar et ...retinal degeneration occurs, and if so to analyse the time course of cell degeneration and phagocytosis of ...
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Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa
... the photoreceptor specific transcription factor network ...of photoreceptor specific genes, we identified splicing defects in gnat1, crx, rx1 and ...maintaining photoreceptor function ...of ...
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The leber congenital amaurosis protein AIPL1 and EB proteins co-localize at the photoreceptor cilium
... the photoreceptor outer segments, AIPL1 is compartmentalized predominantly in the remain- der of the photoreceptors from the synapse to the inner segment, with an enrichment of AIPL1 detected in the region of the ...
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Ohler, Stephan (2012): Photoreceptor axon guidance in Drosophila melanogaster: hu li tai shao and golden goal. Dissertation, LMU München: Fakultät für Biologie
... (A-G) Photoreceptor axons in the medulla of flies with the indicated genotype and GFP as a marker in R8 axons. (A) Homozygous hts G mutants do not exhibit defects. (B) In homozygous hts W532X mutants, single axons ...
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Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility
... rod degeneration )n addition to these signs and symptoms typical of CRD the patient had high myopia Table This subject was also infertile but had been able to have a child by in vitro fertilization (is semen ...
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Atypical retinal pigment epithelial defects with retained photoreceptor layers: a so far disregarded finding in age related macular degeneration
... of photoreceptor-cells ...for photoreceptor survival, may be an underlying cause leading to impaired retinoid transfer from blood to the RPE due to debris accumulation ...
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Cone photoreceptor macular function and recovery after photostress in early non-exudative age-related macular degeneration
... Three groups of subjects – young normal, older normal, and early non-exudative AMD subjects – were tested over a 2-year period. A subgroup consisting of four normal (two young and two old) and eight AMD subjects was ...
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