PI3-K
Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cells
... Our results indicated a role of PI3-K/Akt signaling pathway in mediating the effect of solamargine in inhibition of lung cancer cell growth, suggesting that inactivation of PI3-K/Akt inc[r] ...
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Human Cytomegalovirus Up-Regulates the Phosphatidylinositol 3-Kinase (PI3-K) Pathway: Inhibition of PI3-K Activity Inhibits Viral Replication and Virus-Induced Signaling
... that PI3-K can regulate activation of NF-B (9, 47, 58, 59, ...type, PI3-K can activate NF-B through either ...by PI3-K is thought to be a critical event in both types of ...
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Epstein-Barr Virus Latent Membrane Protein 2A Mediates Transformation through Constitutive Activation of the Ras/PI3-K/Akt Pathway
... the PI3-K/Akt pathway in both HaCaT and HSC-39 cells; however, LMP2A did not activate Ras in HaCaT cells but did in HSC-39 ...the PI3-K inhibitor LY294002 blocked LMP2A-mediated Akt ...
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Original Article Exendin-4 attenuates high glucose-induced endothelial progenitor cells dysfunction through the PI3-K/Akt/eNOS pathway
... the PI3-K/Akt/eNOS sig- naling pathway is critical to modulate the func- tion of EPCs ...the PI3-K/Akt/eNOS signaling pathways are responsible for the impaired func- tion of EPCs in DM ...
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Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations
... and PI3-K were 63/108 ...or PI3-K in gallbladder adenocarcinoma was significantly higher than that in peri-tumor tissue (both, P < ...0.01; PI3-K, P < ...or ...
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Overexpression of PTEN suppresses lipopolysaccharide-induced lung fibroblast proliferation, differentiation and collagen secretion through inhibition of the PI3-K-Akt-GSK3beta pathway
... the PI3-K-Akt-glycogen synthase kinase 3 (GSK3) pathway, suggesting that PTEN may be involved in inactivation of PI3-K signaling ...the PI3-K-Akt pathway suggests that, without ...
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AKT-independent PI3-K signaling in cancer – emerging role for SGK3
... The PI3-K pathway is regarded as one of the most crucial for cancer development and maintenance, with the ubiquitous nature of PI3-K pathway activation making both upstream and downstream ...
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Hammitzsch, Ariane (2011): Einfluss der endothelialen DNA abhängigen Proteinkinase, DNA-PK, auf wachstumsfaktorabhängige angiogene Prozesse und Signaltransduktion. Dissertation, LMU München: Medizinische Fakultät
... zur PI3-Kinase aufweist [72] und des weiteren Hinweise auf Interaktionen mit Wachstumsfaktoren wie FGF-2 bestehen [87], wurde DNA-PK noch nicht in ihrer Rolle in Endothelzellen ...der PI3-K/Akt- und ...
99
By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization
... that PI3-K, ERK1/2 and p38 are able to regulate the phosphorylation of both NF-κB and ...by PI3-K [63], ERK1/2 [64] and p38 [65] in human bronchial epithelial cells, mouse embryonic ...
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P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury
... GLN-mediated PI3-K signaling, however, either hap- pens before FN-Integrin signaling or simultaneously after injury in the ...mediated PI3-K/Akt signaling regulates FN expression and possibly ...
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Latent Membrane Protein 2A-Mediated Effects on the Phosphatidylinositol 3-Kinase/Akt Pathway
... Akt is a multifunctional mediator of PI3-K involved in reg- ulating several cellular functions by interacting with a variety of downstream substrates. Through various cytokines, growth fac- tors, and ...
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The pathophysiology of insulin resistance and modulation by aerobic exercise in obese and Type 2 diabetes subjects
... Finally, the results regarding Akt kinase, which is also involved in GLUT-4 translocation, are controversial. Human studies have shown no change in the phosphorylation or activity o f Akt immediately following exercise ...
140
The role of progranulin in diabetes and kidney disease
... kinase; PI3 K: phosphati- dylinositol 3-kinase; FTD: frontotemporal dementia; TNFR: tumor necrosis factor receptor; TNFα: tumor necrosis factor-α; BMI: body mass index; MCP-1: monocyte chemoattractant ...
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SYK as a New Therapeutic Target in B Cell Precursor Acute Lymphoblastic Leukemia
... SHC, PI3 kinase (PI3-K), SHIP, CBL, and VAV ...anti-apoptotic PI3-K in the BCR signal- ing pathway [9]. SYK can activate PI3-K via adapter proteins such as CBL, a B cell ...
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Anti-inflammatory action of insulin via induction of Gadd45-β transcription by the mTOR signaling pathway
... Abstract: Insulin regulates a large number of genes in a tissue-specific manner. We have previously identified genes modulated by insulin in the liver and in liver-derived cells that have not yet been characterized as ...
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Se methylselenocysteine inhibits phosphatidylinositol 3 kinase activity of mouse mammary epithelial tumor cells in vitro
... although PI3-K activity was inhibited in the MSC-treated cells, the phospho-Akt levels remained unchanged in both the control and MSC-treated ...closely. PI3-K activity was inhibited at about ...
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Inhibitory effects of ZSTK474, a novel phosphoinositide 3 kinase inhibitor, on osteoclasts and collagen induced arthritis in mice
... with PI3-Kγ and induce signals for chemotaxis of the inflammatory cells ...the PI3-Kγ-selective inhibitor suppressed joint inflammation in mouse CIA by inhibit- ing migration of neutrophils to the joints ...
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Ion transport regulation by P2Y receptors, protein kinase C and phosphatidylinositol 3 kinase within the semicircular canal duct epithelium
... The present study augments previous reports of ion transport systems that are expressed and characterized in SCCD epithelium, including sodium absorption and chloride secretion. We showed here that sodium absorp- tion ...
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<p>Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target</p>
... Insulin-like growth factor-I promotes migration in human androgen-independent prostate cancer cells via the alphavbeta3 integrin and PI3-K/Akt signaling. Involvement of the ga[r] ...
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Akt Finds its New Path to Regulate Cell Cycle Through Modulating Skp2 Activity and its Destruction by APC/Cdh1
... activated PI3-K/Akt pathway leads to elevated Skp2 expression and subsequent enhanced p27 destruction in human cancers, providing further evidence that elevated Akt activity and cytoplasmic Skp2 expression ...
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