PI3K/AKT/mTOR pathway
Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway
... the PI3K/Akt/mTOR pathway via RAGE, while blockage RAGE re-activated PI3K/Akt/ mTOR pathway, however, the addition with PI3K inhibitor redeuced the cell ...
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The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines
... cells. PI3K/AKT/mTOR pathway components, PIK3CA, PIK3CD, AKT3, ECM1, GPCR, mTOR and PRKCB were increased but that the Nur77 and PTEN were decreased in A-H/S-H cells, identified by ...
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Angelica Sinensis promotes myotube hypertrophy through the PI3K/Akt/mTOR pathway
... the mTOR phosphorylation level (P < ...of mTOR between 5 and 30 min after the AS treatment of the ...The mTOR phosphorylation behaved similarly to Akt phosphorylation, but more powerfully ...
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LGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway
... Our findings indicated that LGR6 could promote the pro- gression of GC through PI3K/AKT/mTOR pathway. That contributes to figuring out the molecular mechanisms of GC progression. In the ...
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The PI3K-AKT-mTOR pathway activates recovery from general anesthesia
... that PI3K-AKT-mTOR pathway proteins in normal rats were expressed at low levels, while there was increased expression of p-AKT, p-mTOR and p-P70S6K in brain tissues of ...
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PI3K/AKT/mTOR pathway promotes progestin resistance in endometrial cancer cells by inhibition of autophagy
... of Pi3K/aKT/mTOr ...Abbreviations: Pi3K, phosphatidylinositol 3-kinase; aKT, protein kinase B; mTOr, mechanistic target of rapamycin; MTT, ...
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Original Article Prostaglandin transporter, SLCO2A1, mediates the invasion and apoptosis of lung cancer cells via PI3K/AKT/mTOR pathway
... In summary, SLCO2A1 exhibits the ability to mediate the invasion and apoptosis of lung cancer cells, possibly via regulating PI3K/AKT/ mTOR pathway. Knockdown of SLCO2A1 can inhibit lung ...
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<p>Piceatannol Suppresses the Proliferation and Induced Apoptosis of Osteosarcoma Cells Through PI3K/AKT/mTOR Pathway</p>
... mol/L), PI3K/AKT/mTOR pathway inhibitor (LY294002), or pathway activator (740Y-P) plus ...of PI3K/AKT/mTOR pathway-related proteins in cells and tumor ...
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The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis
... the PI3K/ AKT/mTOR ...of PI3K/AKT/mTOR pathway inhibitors requires further ...of PI3K/p-AKT/p-mTOR was ...the mTOR inhibitor could activate ...
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Original Article Role of TM4SF1 in regulating breast cancer cell migration and apoptosis through PI3K/AKT/mTOR pathway
... the PI3K/AKT/mTOR ...down-regulates PI3K/AKT/mTOR pathway associated proteins expressions including p-PI3K, p-AKT, and ...
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Original Article NRSN2 promotes non-small cell lung cancer cell growth through PI3K/Akt/mTOR pathway
... that PI3K/Akt/mTOR pathway which play a centre role in regulating cell prolif- eration and growth [13, 14], and angiogenesis [15], was activated and inactivated after NRSN2 over-expressing or ...
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Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs
... that PI3K inhibition has on glucose homeostasis remains to be ...of PI3K/Akt/mTOR inhibitors that could potentially be used as PD biomarkers include hypertriglyceridemia and hyperglycemia ...
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The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges
... by mTOR. However, mTOR inhibition abolishes IRS-1 phosphorylation, thus allowing IRS- 1 to complex with IGF-1R and promote Akt signaling [52] , and thereby generating a mechanism for escape from ...
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Low-frequency ultrasound enhances chemotherapy sensitivity and induces autophagy in PTX-resistant PC-3 cells via the endoplasmic reticulum stress-mediated PI3K/Akt/mTOR signaling pathway
... P-glycoprotein), PI3K/AKT/mTOR pathway-related proteins (PI3K, p-AKT, mTORC1), and apoptosis-related proteins (Bcl-2, NF-κB) decreased in PTX-resistant PC-3 cells after low- ...
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Original Article The exosome-mediated PI3k/Akt/mTOR signaling pathway in cervical cancer
... the PI3k/Akt/mTOR sig- naling pathway and its regulatory mechanism are not fully understood, and there are still many problems to be further ...the PI3k/ Akt/mTOR ...
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Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization
... SFV-induced PI3K-Akt-mTOR ...the PI3K-Akt-mTOR pathway is affected by infection of cells with SFV and to what extent this is influenced by nutrient availability, generally ...
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Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen
... to PI3K pathway inhibitors we screened compounds targeting PI3Kα/δ (AZD8835), PI3Kβ/δ (AZD8186), AKT (AZD5363) and mTORC1/2 (AZD2014) against a cancer cell line panel (971 cell ...to AKT and ...
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Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice
... the AKT/mTOR signal- ing pathway and down-regulation of caspase-3 in rats sub- jected to phototrombic stroke ...ROS/JNK/p53 pathway in colorectal cancer cells ...through ...
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Scutellarin inhibits the metastasis and cisplatin resistance in glioma cells
... of PI3K/Akt pathway, LY294002 could enhance the effects of scutellarin on cell migration, invasion, and cisplatin- induced cell death in U87 cells (Figure ...of PI3K/AKT/mTOR ...
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Targeting the PI3K/Akt/mTOR Signaling Pathway: Applications of Nanotechnology
... (9). mTOR is involved in a pathway, known as PI3K/Akt/mTOR signaling pathway that regulates cellular growth behaviors which has the potential to lead to ...that mTOR does ...
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