PI3K/Akt/mTOR phosphorylation
NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/ mTOR phosphorylation
... NVP-BEZ235 was purchased from Selleck Chemicals (Houston, TX, USA), dissolved in dimethyl sulfoxide (DMSO) (Amresco LLC, Solon, OH, USA) to 10 mmol/L. Gefitinib was kindly supplied by AstraZeneca and dissolved in DMSO to ...
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Original Article On the in vitro anti-myeloma effect and mechanism of Andrographolide through PI3K/AKT/mTOR and AMPK/mTOR dual signaling pathways
... downstream mTOR, as well as playing the anti-tumor ...stream PI3K proteins were found to be redu- ced using Western blot, which resulted in the inhibition of AKT and mTOR ...
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Progesterone Induces NFκB DNA Binding Activity through a PI3K/Akt-Dependent Pathway in MCF-7 Breast Cancer Cells
... and Akt. The Akt family of serine-threonine kinases is the primary downstream mediator of PI3K, and through the phosphorylation of target substrates mediates a number of cell processes [24, ...
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Hyperglycemia and Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) Inhibitors in Phase I Trials: Incidence, Predictive Factors, and Management.
... using PI3K inhibitors have not reported dramatic hyperglycemia, an effect that may be related to the p110 isoform of the PI3K that is inhibited: a pan class 1A inhibitor may lead to more severe glucose ...
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PKD knockdown inhibits pressure overload-induced cardiac hypertrophy by promoting autophagy via AKT/mTOR pathway
... through mTOR pathway, 3-MA was used in this study, which is demonstrated to inhibit autophagy by blocking autophagosome formation via the inhibition of phosphatidylinositol 3-kinases ...the phosphorylation ...
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Synaptopodin-2 plays an important role in the metastasis of breast cancer via PI3K/Akt/mTOR pathway
... The PI3K/AKT/mTOR pathway plays an important role in cancer cell ...the PI3K/ AKT/mTOR signaling pathway, we used Western ...the phosphorylation levels of PI3K, ...
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PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
... of Akt, and the tuberous sclerosis complex 1/2 (TSC1/TSC2) heterodimer, act- ing as a brake downstream of Akt and upstream of ...of Akt through its phosphatase activ- ity on PtdIns(3,4,5)P(3), which ...
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Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice
... that phosphorylation of Bad by AKT resulted in cell survival ...that AKT/Bad was activated during hypoxia ...the AKT/ Bad pathway was ...the AKT/Bad cell survival ...
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Targeting the PI3K/Akt/mTOR Signaling Pathway: Applications of Nanotechnology
... (9). mTOR is involved in a pathway, known as PI3K/Akt/mTOR signaling pathway that regulates cellular growth behaviors which has the potential to lead to ...that mTOR does its function ...
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Original Article NRSN2 promotes non-small cell lung cancer cell growth through PI3K/Akt/mTOR pathway
... As PI3K/Akt/mTOR pathway plays a key role in NSCLC cell growth [11], we examined the effect of NRSN2 silencing and over-expressing on the expression of phosphorylated Akt and phos- phorylated ...
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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
... of Akt and mTOR by perfosine and temsirolimus inhibited murine glioblastoma growth no matter PTEN status, a phase I/II trial in recurrent high-grade gliomais ongoing (NCT01051557) [75, ...block Akt ...
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Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas
... of PI3K pathway components on patients’ ...S6 phosphorylation in either Ser235/236 or Ser240/244 had a significantly better disease-specific survival (Log- rank test, P < ...
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IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways
... the PI3K/ AKT/mTOR pathway participates in regulating cellu- lar events, such as cell growth, adhesion, migration and survival ...of AKT signalling can contribute to cell proliferation and ...
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Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization
... SFV-induced PI3K-Akt-mTOR ...the PI3K-Akt-mTOR pathway is affected by infection of cells with SFV and to what extent this is influenced by nutrient availability, generally a pre- ...
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Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs
... generation PI3K inhibitors that showed proof-of-concept whereby targeting members of the PI3K family with high selectivity was able to achieve target modulation with resultant in vivo antitumor activity ...
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The Multiple Molecular Signatures in Gallbladder Carcinoma: from Basic Studies to Clinical Application
... through phosphorylation [74] and MUC4 interacted with ErbB2 to cause tumor growth, which was related to the hyperphosphorylation of ErbB2, MAPK and Akt ...the phosphorylation of Akt [77] and ...
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Original Article 17β-estradiol activates mTOR in chondrocytes by AKT-dependent and AKT-independent signaling pathways
... of PI3K could only partly influence the activation of mTOR by E2, demon- strating that E2 activates mTOR independently through PI3K-AKT-mTOR, there might be other involved ...and ...
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Original Article The exosome-mediated PI3k/Akt/mTOR signaling pathway in cervical cancer
... of PI3k, Akt, and ...and PI3k (1:200), Akt (1:100) and mTOR (1:100) rabbit monoclonal antibod- ies were provided by Zhongshan Jinqiao Bio- technology ...
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PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs
... reduced the contractile effect of PDGF-BB, whereas none of the inhibitors, including the IP-receptor antagonist RO-1138452, did increase PDGF-BB-induced contraction. At first glance, PDGF-BB-downstream-signalling appears ...
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A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkin’s lymphoma
... standard of care ABVD chemotherapy (doxorubicin, bleomycin, vinblastine and dacarbazine) for 6 cycles. Unfortunately, she had persistent lymphoma. She then received ifosfamide, carboplatin and etoposide (ICE) therapy for ...
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