PI3K/Akt/NF-κB
Original Article CXCR4 was involved in andrographolide inhibits atherosclerosis by inactivating the PI3K/AKT/NF-κB signaling pathway
... Abstract: Atherosclerosis is one of the major diseases that seriously impacts human health, which has been con- ceived as a complex process. In this study, we sought to explore the role and the underlying mechanism of ...
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Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway
... (PI3K)-p85, PI3K-p110, total AKT, p-AKT (Ser473) and p-AKT (Thr308) in the liver of NDEA group rats were higher than those in control group ...and NF-κB p65 ...
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Original Article Knockdown of Aurora-B inhibits osteosarcoma cell invasion and migration via modulating PI3K/Akt/NF-κB signaling pathway
... tein samples were denatured at 100°C for 10 min and then preserved at -20°C for later use. The protein samples were separated by 8% SDS-polyacrylamide gels and transblotted onto Nitrocellulose blotting membrane (0.22 ...
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Original Article The pro-inflammatory effect of uric acid in human umbilical vein endothelial cells via ROS-PI3K/AKT-NF-κB signal pathway
... While, NF-κB plays a prominent role in transcriptional re- gulation of most inflammatory genes that con- tribute to the development of the expressions of many inflammatory cytokines ...of ...
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Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats
... (4) PI3K/Akt signal- ing pathway was the underlying mechanism of the neu- roprotection provided by ...downstream NF-κB p65, which was associated with upregulation of endothelial junction ...
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Si Wu tang extract stimulates bone formation through PI3K/Akt/NF κB signaling pathways in osteoblasts
... Si-Wu-Tang (SWT), a Traditional Chinese Medicine (TCM) formula, is comprised of a combination of 4 herbs; Paeoniae, Angelicae, Chuanxiong, and Rehmanniae, and is widely used for the treatment of women’ s diseases such as ...
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Zuo Jin Wan reverses P gp mediated drug resistance by inhibiting activation of the PI3K/Akt/NF κB pathway
... p50/p65 NF-κB proteins and their binding to target genes ...the PI3K/Akt/NF-κB pathway, and stop the translocation of NF-κB ...the ...
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Original Article CXCR4 enhances invasion and proliferation of bone marrow stem cells via PI3K/AKT/NF-κB signaling pathway
... Abstract: Osteosarcoma is the most common type of cancer that develops in bone, specifically; it is an aggressive malignant neoplasm. The purpose of this study is using superparamagnetic iron oxide nanoparticles (SPION) ...
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Bovine ephemeral fever virus triggers autophagy enhancing virus replication via upregulation of the Src/JNK/AP1 and PI3K/Akt/NF-κB pathways and suppression of the PI3K/Akt/mTOR pathway
... the PI3K/Akt/NF-κB and Src/JNKAP1 pathways at virus binding stage to enhance virus entry ...activates Akt and inhibits mTORC1 to benefit BEFV replication ...up-regulates Akt to ...
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Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice
... inhibit NF-κB activ- ity and down-regulate the production of inflammatory mediators, such as nitric oxide (NO) and TNF-α [25, ...the PI3K and NF-κB signaling pathways ...
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Original Article Endogenous SARI exerts oncogenic functions in human K562 leukemia cells by targeting the PI3K/Akt/mTOR and NF-κB signaling pathways
... the PI3K/Akt/mTOR singling in K562 leukemia cells. The NF-κB signaling is also one of the well-known pathways that are implicated in cancer progression and angiogenesis ...[29]. ...
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CCN4 induces IL 6 production through αvβ5 receptor, PI3K, Akt, and NF κB singling pathway in human synovial fibroblasts
... for PI3K, Akt, IKKa/b, IB, p65, and b-actin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, ...for PI3K phosphorylated at Tyr 458/199 , Akt phosphorylated at ser 473 , IKKa/b ...
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Original Article shRNA-mediated silencing of PKHD1 gene promotes proliferation, migration and invasion of human intrahepatic cholangiocarcinoma HuCCT-1 cells
... of PI3K, Akt, p-Akt, and NF-κB expression in LV3-PKHD1 transfected HuCCT-1 cells as compared to that in the LV3NC-transfected and nontransfected cells (P < ...the ...
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Original Article UHMWPE wear particles and dendritic cells promote osteoclastogenesis of RAW264.7 cells through RANK-activated NF-κB/MAPK/AKT pathways
... p38MAPK, AKT, and NF-κB were acti- vated in ...ture. NF-κB was the main player mediating RANKL/RANK regulation of osteoclastogenic gene expression besides its role in inflamma- tory ...
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Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes
... nases, NF-κB, and PI3K/Akt pathways ...of PI3K pathway, measured by the phosphoryl- ation of its downstream target Akt, was decreased by 76 % in the presence of Sialo ...
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Decreased SATB1 expression promotes AML cell proliferation through NF-κB activation
... in NF-κB, MAPK and PI3K/Akt signaling pathways, we assessed the protein levels and found that nuclear NF-κB p65 levels were significantly increased in HL-60 SATB1-shRNA cells, ...
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Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes
... factor of mitochondrial apoptosis pathway. The Cyt c is released from injured mitochondria and triggers cyto- solic caspase-3 activation through formation of the cytochrome c/Apaf-1/caspase-9-containing complex ...
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Original Article Differences in gene expression profiles and signaling pathways in rhabdomyolysis-induced acute kidney injury
... the PI3K/Akt, MAPK, and NF-κB signaling ...the NF-κB, MAPK, PI3K/Akt, and apoptotic pathways are regulated in rhabdomyolysis- induced ...
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Original Article Molecular biological characteristics of the recruitment of hematopoietic stem cells from bone marrow niche in chronic myeloid leukemia
... Generally speaking, as what is schematically represented in Figure 4, we demonstrated a decisive checkpoint for MMP-9 to rapidly release the stem cell-active cytokines s-KitL and s-ICAM-1, thereby directing tumor cell ...
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Vol 68, No 3 (2016)
... The PI3K/Akt signaling has been implicated in differentiation of cells such as skeletal muscle cells, adipocytes, osteoblasts, chondrocytes and myoblasts ...the PI3K/Akt signaling pathway in ...
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