PI3K Inhibitor
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer
... the PI3K pathway, but also to an accumulation of DNA DSBs and thus synthetic lethal interaction with PARP inhibition [25, ...PARP inhibitor Olaparib with differential ...with PI3K inhibitor ...
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Original Article Effective use of PI3K inhibitor BKM120 to treat human osteosarcoma
... the PI3K inhibitor BKM120 as a potential therapeutic inhibitor of the PI3K/AKT pathway was demon- strated in the human ...the PI3K/AKT pathway [23, ...
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The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy
... the PI3K/ AKT signaling pathway, the phosphorylation status of the most prominent PI3K downstream signaling molecule, AKT, was selected as a valid marker for PI3K activity ...the PI3K/AKT ...
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Copanlisib for treatment of B-cell malignancies: the development of a PI3K inhibitor with considerable differences to idelalisib
... I PI3K inhibitor copanlisib as a drug for the treatment of B-cell malignancies in comparison with other kinase inhibitors targeting B-cell- receptor signaling, in particular with strictly ...
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The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer
... known PI3K inhibitors, BYL719 and BKM120, flupentixol showed more potent cytotoxicity in A549 and H661 ...pan-PI3K inhibitor BKM120 showed a significant cytotoxic activity on various tumor cell ...
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HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer
... novel PI3K inhibitor blocked the process of EMT in pancreatic ...the PI3K/AKT/mTOR and Smad2/3 signaling pathways in pancreatic cancer ...inhibiting PI3K/AKT/mTOR and Smad2/3 signaling ...
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Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization
... S14161 has been demonstrated as a pan-PI3K inhibi- tor, which has no effects on PI3K associated enzymes in- cluding AKT, mTOR, PDK1 or GSK-3β. Cell-based and mice-based studies showed that S14161 could be a ...
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Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy
... III PI3K inhibitor traditionally used as a selective inhibitor of the autophagy pathway, modulated cytokine responses in response to infection of BEAS-2B epithelial ...
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Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002
... (PI3K) inhibitor LY294002 in colon carcinoma ...Gli inhibitor arsenic trioxide and PI3K inhibitor LY294002 significantly reduced Gli1 protein expression and colon carcinoma cell ...the ...
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Casticin inhibits nasopharyngeal carcinoma growth by targeting phosphoinositide 3-kinase
... manipulating PI3K-mediated alterations has become an attractive tar- get for cancer therapy, and great efforts are underway to develop effective PI3K ...pan-PI3K inhibitor, is being tested in ...
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Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase
... the PI3K signaling pathway has been directly correlated to oncogenic activity, due to its prominent role in mediating cellular growth and survival [18, 20, ...of PI3K [22, 24]. Class-IA PI3K are ...
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Phosphoinositide 3-kinase inhibitor AS605240 ameliorates streptozotocin-induced Alzheimer’s disease like sporadic dementia in experimental rats
... a PI3K inhibitor, AS605240 on cognitive dysfunction and antioxidative defense parameters against intra-cerebroventricular-strep- tozotocin (ICV-STZ)-induced rat model of sporadic AD was ...
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Varicella-Zoster Virus ORF12 Protein Activates the Phosphatidylinositol 3-Kinase/Akt Pathway To Regulate Cell Cycle Progression
... the PI3K inhib- itor ...the PI3K inhibitor greatly reduced the levels of Akt activation by ROka and ...on PI3K and independent of ...of PI3K. Many viral proteins that activate the ...
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In Silico Analysis of Picfeltarraenin IA and IB as Potential PI3K and EGFR Inhibitor
... was PI3K binding pocket with the Protein Data Bank (PDB) code 3DBS and 1M17 for ...standard PI3K inhibitor were generated by Marvin Sketch ...
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Novel naphthochalcone derivative accelerate dermal wound healing through induction of epithelial-mesenchymal transition of keratinocyte
... the PI3K/AKT pathway, are important for the regulation of cell migra- ...a PI3K inhibitor (LY49002, 50 μM) and a MEK inhibitor (PD98059, 50 μM) then treated with TDPN or left ...
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Vol 68, No 3 (2016)
... the PI3K/Akt signaling pathway by targeting ...the PI3K/Akt signaling in N-CoR- regulated osteogenic differentiation, we used the PI3K inhibitor (LY294002) to block the activation of the ...
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Profile of buparlisib and its potential in the treatment of breast cancer: evidence to date
... targeting PI3K/Akt/mTOR, such as PI3K inhibitors (panspecific or specific to the subunit 110 α or δ ), AKT inhibitors, mTOR inhibitors, or dual inhibitors of mTOR and ...only PI3K inhibitor ...
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Efemp1 and p27 Kip1 modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models
... the PI3K pathway, PI3K inhibitors are promising therapeutic targets in solid tumors [14] including PDAC ...dual PI3K-mTOR inhibitor Bez235 revealed efficacy in in vivo models of PDAC [15, ...I ...
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Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen
... the PI3K inhibitors across the T-ALL cell line ...lines. PI3K isoform selectivity of the PI3K- selective inhibitors was determined in enzyme and cell based assays and demonstrate that GDC0941 and ...
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QSAR, Molecular Docking and Dynamics Studies of Quinazoline Derivatives as Inhibitor of Phosphatidylinositol 3-Kinase
... Nishimura N, Siegmund A, Liu L, Yang K, Bryan MC, Andrews KL, Bo Y, Booker SK, Caenepeel S, Freeman D, Liao H, McCarter J, Mullady EL, Miguel TS, Subramanian R, Tamayo N, Wang L, Whittington DA, Zalameda L, Zhang N, ...
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