PI3K pathway
REC8 is a novel tumor suppressor gene epigenetically robustly targeted by the PI3K pathway in thyroid cancer
... the PI3K pathway in human cancer has been well established, but much of its molecular mechanism, particularly the epigenetic aspect, remains to be ...activated PI3K pathway signaling is a ...
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Will PI3K pathway inhibitors be effective as single agents in patients with cancer?
... the PI3K pathway, ...the pathway more strongly and/or whether they are clinically well tolerated and feasible remains to be ...of PI3K in prostate cancer cells activates signaling by the ...
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The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines
... The PI3K pathway can be activated by FAKs ...39]. PI3K is the central link in the PI3K/AKT pathway; therefore, PI3K plays a crucial role in this ...
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Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2 amplified gastroesophageal adenocarcinoma
... In earlier studies, we demonstrated that the genomes of pri- mary, previously untreated GE adenocarcinoma have a rich spec- trum of somatic copy-number alterations (26) and point muta- tions (27). Based on these ...
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MCL-1-independent mechanisms of synergy between dual PI3K/ mTOR and BCL-2 inhibition in diffuse large B cell lymphoma
... BAD, PI3K pathway inhibitors increase the concentration of endogenous BCL-2 antagonists (BAD and BIM protein), which can predictably enhance the effects of pharmacological BCL-2 antagonists (ABT- 199/263) ...
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Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
... Although mutant FGFR3 activates MAPK pathway but not PI3K pathway signalling in NHUCs61, immunohistochemistry for phosphorylated ERK an indicator of MAPK pathway activation does not show[r] ...
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A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma
... targeting PI3K pathway is a promising strategy for the treatment of blood ...novel PI3K inhibitors, we performed a high throughput virtual screen and identified several novel small molecule ...
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Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kα-selective Inhibitors in Breast Cancer
... development. PI3K pathway is frequently hyper-activated not only in ER-positive breast cancers but also in other types of breast cancer, which validates PI3K as a promising target for breast cancer ...
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Original Article The characterization and clinical significance of PI3K/ Akt signaling pathway activation in the peripheral T cells of pediatric patients with atopic dermatitis
... of PI3K pathway activation in peripheral T cells from AD patients, we investigated the relation- ships between PI3K pathway expression and T cell proliferation, cytokine secretion, and the ...
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RICTOR involvement in the PI3K/AKT pathway regulation in melanocytes and melanoma
... the PI3K pathway in melanocytes, restricting their ...the PI3K/AKT pathway is frequent in melanoma and may enhance this negative feedback, so malignant cells will have to find a way to ...
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<p>Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis</p>
... bronchodilatory, anti-tumor, anti-ulcer, and anti-viral functions. 9 The anti-tumor effect of GA has been reported in various types of tumors, such as those of the lung, liver, breast and cervix as well as in ...
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Original Article Interaction of key pathways in sorafenib-treated hepatocellular carcinoma based on a PCR-array
... Latent pathway identification analysis ...signaling pathway was the most significant interaction ...signaling pathway, Chagas disease, and T cell receptor signaling pathway were the ...
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Expression of HSP90AA1/HSPA8 in hepatocellular carcinoma patients with depression
... Candidate functions and pathways enriched in the presence of depression were analyzed using several online databases, including DAVID, KEGG PATHWAY (www.genome.jp/ kegg), Reactome (www.reactome.org), BioCyc ...
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<p>MicroRNA-145 inhibits growth of laryngeal squamous cell carcinoma by targeting the PI3K/Akt signaling pathway</p>
... Zhao et al, 17 analyzed miR-145 and MYO5A expres- sion in 132 patients with LSCC, and evaluated associa- tions between this expression and clinicopathological features. They observed a regulatory relationship between ...
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The Mechanism Study of Dracocephalum Moldavica L. Total Flavonoids on Apoptosis induced by Myocardial Ischemia/Reperfusion injury in vivo and in vitro
... Dracocephalum moldavica L. is a commonly medicinal plant of Uygur and Mongolian nationalities and has a medicinal history for hundreds of years. It has been confirmed to have protective effects against myocardial ...
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The PI3K/Akt Pathway Contributes to Arenavirus Budding
... the PI3K/Akt pathway in the late steps of the virus life ...(MVB) pathway (27), and biogenesis and functionality of the MVB require the lipid PI3P and hence also PI3K ...the PI3K ...
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Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines
... The purpose of this study is to find out how and the degree to which tau contributes to resistance to chemotherapeutic drugs in prostate cancers and to put forward a molecular biological foundation for inactivation of ...
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Original Article The role of the PI3K/Akt/GSK-3β pathway in postoperative cognitive dysfunction in elderly rats
... the PI3K/Akt/GSK-3β pathway in POCD in elderly rats was also studied using 22-month-old female Sprague Dawley (SD) rats that were randomly assigned into a sham group, a splenectomy group and an anesthesia ...
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T cell receptor signaling for γδT cell development
... produced IL-17, whereas antigen-experienced γδT cells that developed in the presence of the ligands predomin- antly produced IFNγ [11]. This study first suggested the idea that a ligand-induced strong γδTCR signal and a ...
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Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma
... HRAS/PI3K/AKT pathway could impair other pro- apoptotic signals, we treated HepG2 cells with ...HRAS/PI3K/AKT pathway at 48 hours, while knockdown of HRAS, PI3K or AKT enhanced ...
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