pigment epithelium-derived factor
Loss of pigment epithelium derived factor: a novel mechanism for the development of endocrine resistance in breast cancer
... Pigment epithelium-derived factor (PEDF) is a 50 kDa glycoprotein that belongs to the non-inhibitory serine pro- tease inhibitor superfamily but it does not inhibit proteases ...a ...
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Original Article Inhibitory effects of pigment epithelium-derived factor on epithelial-mesenchymal transition, migration and invasion of breast cancer
... Objective: Pigment epithelium-derived factor (PEDF) is a ubiquitously expressed secreted protein that suppresses tumor growth and metastasis by targeting tumor cells and their ...angiogenesis, ...
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Pigment epithelium-derived factor alleviates endothelial injury by inhibiting Wnt/β-catenin pathway
... Pigment epithelium-derived factor (PEDF) belongs to the serine protease inhibitor supergene family. As previ- ously confirmed, PEDF is a type of endogenously pro- duced multifunctional protein ...
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Decreased Cerebrospinal Fluid and Serum Concentrations of Pigment Epithelium-Derived Factor in Drug-Refractory Epilepsy Patients
... Citation: Dan Chen, Zheng Xiao, Liang Wang, Fei Xiao, Zhi Qin Xi, Xue Feng Wang, Qiao Cheng. Decreased Cerebro- spinal Fluid and Serum Concentrations of Pigment Epithelium-Derived Factor in ...
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Circulating levels and subcutaneous adipose tissue gene expression of pigment epithelium-derived factor in polycystic ovary syndrome and normal women: a case control study
... hypertension. Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor family, is a pleiotropic protein known for its antiangiogenic, antioxidant, and ...
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Interplay between Platelet Endothelial Cell Adhesion Molecule 1 and Pigment Epithelium Derived Factor in Non Small Cell Lung Cancer
... Pigment epithelium-derived factor (PEDF), a potent antiangiogenesis agent, is a multifunctional protein with important roles in regulation of inflammation and an- ...
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Elevated plasma levels of pigment epithelium-derived factor correlated with inflammation and lung function in COPD patients
... of pigment epithelium-derived factor (PeDF) in the plasma from the healthy nonsmokers group, healthy smokers group, and chronic obstructive pulmonary disease (COPD) ...
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The effects of pigment epithelium-derived factor on atherosclerosis: putative mechanisms of the process
... Nuclear factor- κ B; Ox-LDL: oxidized-low density lipoprotein; PEDF: Pigment epithelium-derived factor; PLA 2 : Phospholipase A 2 ...
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Identification of Pigment Epithelium-Derived Factor as an Adipocyte-Derived Inflammatory Factor
... risk factor for insulin resistance, type 2 diabetes mellitus and cardiovascular ...adipocyte-derived factor might stimulate acti- vation of ...identified pigment ...
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Pigment Epithelium Derived Factor (PEDF) mediates cartilage matrix loss in an age dependent manner under inflammatory conditions
... be pigment epithelium- derived factor (PEDF), which is a 50kD secreted glyco- protein belonging to the non-inhibitory family of serine protease inhibitors (Serpins) [15, ...necrosis ...
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Anti-tumor effect of adenovirus-mediated gene transfer of pigment epithelium-derived factor on mouse B16-F10 melanoma
... One hallmark of melanoma progression is angiogenesis, which is induced by angiogenic factors released by tumor cells and characterized as the formation of a new vascular network from pre-existing blood vessels. ...
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Prognostic Significance of Pigment Epithelium Derived Factor Expression in Patients with Non Small Cell Lung Cancer
... anti-angiogenic factor to be identified ...prognostic factor in ...prognostic factor-in PEDF positive samples, patient survival was significantly longer than when PEDF was not expressed ...
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Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review
... PEDF is a selective inhibitor of angiogenesis and targets only new vessel growth while sparing the pre-existing vasculature [90, 91]. Dawson et al. were the first to suggest a role for PEDF in angiogenesis [13]. They ...
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Pigment Epithelium-Derived Factor (PEDF) Peptide Eye Drops Reduce Inflammation, Cell Death and Vascular Leakage in Diabetic Retinopathy in Ins2Akita Mice
... of hyperglycemia. Peptides, labeled with Alexa Fluor 488, were observed penetrating the cornea by 1–4 h and gained access to the ciliary body, retinal pigment epithelium (RPE)-choroid complex, retina ...
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Osteogenic Effects of Pigment Epithelium Derived Factor on Mesenchymal Stem Cells
... 127 that have utilised fast-degradable hydrogels such as gelatine and collagen. Degradation and cell release are two important parameters in successful bone tissue formation. A fast degradation rate (degradation in less ...
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Serum pigment epithelium-derived factor levels are independently correlated with the presence of coronary artery disease
... more frequently than their counterparts with TG levels in the normal range and TG has been identified as an in- dependent risk factor for coronary events [25,26]. In the current study, TG was found to be strongly ...
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Original Article The expressions of pigment epithelium-derived factor and adipose triglyceride lipase in human kidney and correlation with renal lipid accumulation
... We showed that PEDF and ATGL protein levels were significantly decreased in human diabetic kidney, while the renal lipid accumulation was increased.. These findings showed the importance[r] ...
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Analysis of the proteome of human airway epithelial secretions
... (GST), pigment epithelium-derived factor, peroxiredoxin 1 (Prdx1), lactate dehydrogenase, lactotransferrin, ubiqui- tin, and ubiquitin-conjugating enzyme E2 ...
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Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration
... necrosis factor- α (Mukherjee et al ...2007). Pigment epithelium- derived factor (PEDF), secreted by RPE cells, is a trophic factor required for RPE cell function and survival ...
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Visual prognosis and vitreous molecules after vitrectomy for macular edema with branch retinal vein occlusion
... growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and pigment epithelium-derived factor (PEDF) influence the visual prognosis of patients with macular edema and ...
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