PIK3CA gene
Study on PIK3CA Gene Mutations in Oral Squamous Cell Carcinoma Among South Indian Populations
... frequency PIK3CA gene is responsible for the synthesis of the PIK3CA lipid kinase ...The PIK3CA gene exon 9 and exon 20, encodes for helical domain and as well for kinase domain ...of ...
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Relative quantification of PIK3CA gene expression level in fine-needle aspiration biopsy thyroid specimens collected from patients with papillary thyroid carcinoma and non-toxic goitre by real-time RT-PCR
... of PIK3CA gene have been proved to increase expression of PIK3CA gene, as ...in PIK3CA gene have been reported in many human cancer types, including thyroid ...of PIK3CA ...
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Clinical pitfalls in the diagnosis of segmental overgrowth syndromes: a child with the c.2740G > A mutation in PIK3CA gene
... The diagnosis of MCAP syndrome could be established in our patient according to the clinical criteria of MCAP (Table 2), supported by the correlation between MCAP phenotype and the point mutation c.2740G > A in ...
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PRELIMINARY STUDY ON THE OCCURRENCE OF PTEN AND PIK3CA GENE MUTATIONS IN ENDOMETRIAL CANCER AMONG MALAYSIAN WOMEN
... PIK3CA gene mutation was highly expressed in our study, where it demonstrated at least 55% frequency in all three different exons ...examined. PIK3CA is an important catalytic subunit of the ...
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A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene
... the PIK3CA gene have been identified in a variety of human malignancies and are commonly detected in hotspot codons located in the helical and kinase domains in exons 9 and ...of PIK3CA mutations are ...
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TP53 and PIK3CA gene mutations in adenocarcinoma, squamous cell carcinoma and high grade intraepithelial neoplasia of the cervix
... Mutated PIK3CA gene is becoming a promising target for newly discovered anticancer ...with PIK3CA mutations treated with PI3K/AKT/mTOR in- hibitors demonstrated a higher response rate than patients ...
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Treatment against Mutation of PIK3CA Gene Involved in Lung Cancer by Structure Base Pharmacophore Modeling, Virtual Screening and Molecular Docking
... Six mutated proteins of gene PIK3CA involved in lung cancer were downloaded by using Pdb (www.rcsb.org). 5UK8 is the co-structure of (R)-4-(6-(1-(cyclopropyl sulfonyl) cyclopropyl)-2-(1H-indol-4-yl) ...
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Original Article Genetic association between PIK3CA gene and oral squamous cell carcinoma: a case control study conducted in Chongqing, China
... Abstract: PIK3CA has been shown to be involved in many malignant ...of PIK3CA in oral squamous cell carcinoma (OSCC) and the association of gene poly- morphisms of PIK3CA with OSCC in Chinese ...
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Silencing the PIK3CA Gene Enhances the Sensitivity of Childhood Leukemia Cells to Chemotherapy Drugs by Suppressing the Phosphorylation of Akt
... anti-human PIK3CA, AKT, pAKT, 1:1000, Cell Signaling, Bos- ton, MA, USA) were used to incubate membranes for 12 h at 4°C, followed by 1 h incubation with horseradish peroxidase- labeled goat anti-rabbit IgG ...
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PIK3CA mutation in gastric cancer and the role of microsatellite instability status in mutations of exons 9 and 20 of the PIK3CA gene
... that PIK3CA patients were older and showed intestinal histotype more often but without sta- tistical ...– PIK3CA mutations were more commonly seen in the upper third of the stomach and also showed only ...
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Original Article PIK3CA mutations and downstream effector p-mTOR expression: implication for prognostic factors and therapeutic targets in triple negative breast cancer
... Although PIK3CA mutations and phosphorylated mTOR (p-mTOR) expression are two main events on PI3K/Akt/mTOR pathway, limited data has reported their roles in triple negative breast cancer ...Therefore, ...
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Somatic alterations of targetable oncogenes are frequently observed in BRCA1/2 mutation negative male breast cancers
... two PIK3CA mutations, ...in PIK3CA are rare phenomena [49]. To exclude that a pseudogene of PIK3CA located on chromosome ...of PIK3CA exons 9-13 ...true-specific PIK3CA and pseudogene ...
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Somatic mutation and gain of copy number of PIK3CA in human breast cancer
... for PIK3CA and β -actin amplification were generated using seri- ally diluted MCF12A DNA, and showed linearity over the range ...for PIK3CA amplifica- tion with a slope of ...the gene copy number in ...
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PIK3CA Mutation Analysis in Iranian Patients with Gastric Cancer
... of PIK3CA gene in a significant number of Iranian patients with gastric ...this gene in gastric cancer samples [5,6] ...two PIK3CA exons in a study conducted in Japanese patients [6] , ...
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<em>PIK3CA</em> gene mutation associated with poor prognosis of lung adenocarcinoma
... reported PIK3CA mutations were localized at hotspots in exon 9 and exon 20 of the ...the PIK3CA mutations leads to increased oncogenic potential in vitro and in ...Direct gene sequencing has been ...
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Prognostic implications of PIK3CA amplification in curatively resected liposarcoma
... Despite first-line standard treatment with doxorubicin, median survival remains dismal. gemcitabine and docetaxel are frequently used as second-line treatment for STS [30]. While the total response rate for all patients ...
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PIK3CA Mutations in Resected Small Cell Lung Cancer
... (PIK3CA) gene, which encodes the p110α catalytic sub- unit, plays a key role in the activation of AKT downstream signaling and mammary tumor ...of PIK3CA mutations are clustered in the helical (exon ...
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Review Perspective: Potential impact and therapeutic implications of oncogenic PI3K activation on chromosomal instability
... wild-type PIK3CA gene is also frequently amplified in cancer, such as in lung squamous carcinoma where this occurs as part of amplification of the 3q genomic locus, the most common genomic aberration in ...
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Original Article PIK3CA polymorphisms associated with susceptibility to hepatocellular carcinoma
... The gene commonly exists in an inactive state, and usually cannot be easily ...that PIK3CA gene expresses in such human organs as brain, oral cavity, lung, breast, liver, esophagus, gastrointestine, ...
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<p>An <em>EGFR</em>-Amplified Cervical Squamous Cell Carcinoma Patient with Pulmonary Metastasis Benefits from Afatinib: A Case Report</p>
... Figure 2 Demonstration of EGFR amplification detected in primary and metastatic lesions. (A) NGS detected an EGFR copy number (CN) of 15.9 in primary cervical lesion. The 520 oncogenic genes of the panel are displayed ...
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