PK, pyruvate kinase
Evaluation of tumor M2 pyruvate kinase (Tumor M2 PK) as a biomarker for pancreatic cancer
... of pyruvate kinase [1 – ...M2- pyruvate kinase as a diagnostic test for pancreatic cancer ...M2-pyruvate kinase had an area under the curve (AUC) of ...
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Prevalence of Pyruvate Kinase Deficiency among the Newborns (Shiraz-Iran)
... Phosphoglycerate kinase which are X-linked, the other 12 hereditary erythrocyte enzyme abnormalities that result in heridatery non-spherocytic hemolytic anemia (HNSHA) have autosomal recessive (AR) ...to PK ...
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Selective reticulocyte destruction in erythrocyte pyruvate kinase deficiency
... of PK exhibit very low glycolytic rates and thus are uniquely reliant upon oxidative ...with PK activity, can meet the increased ATP requirements of young ...
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Endothelial pyruvate kinase M2 maintains vascular integrity
... of PK-independent PKM2 functions, including a report of interaction with p53 upon DNA damage in human tumor cells that include MCF7 breast cancer, HCT116 colon cancer, and U2OS osteosarcoma cells ...
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Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis
... 12]. Pyruvate kinase (PK) is a key enzyme that catalyzes the final, rate-limiting step of glycolysis by transferring a phosphate group from phosphoenolpyruvate to ADP [13, ...muscle-type PK ...
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Probing Conformational Feature of a Recombinant Pyruvate Kinase by Limited Proteolysis
... of Pyruvate kinase will help to take advantage of the enzyme. PK have been isolated and characterized from a number of prokaryotes and eukaryotes, mostly in form of tetramers of identical subunits ...
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Warburg effect hypothesis in autism Spectrum disorders
... into pyruvate is the final step in glycolysis after glucose entered the ...enzyme pyruvate kinase (PK) catalyzes this reaction. PK have four isoforms: PKM1, PKM2, PKL, and ...
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Cadmium induces both pyruvate kinase and Na+/H+ exchanger activity through protein kinase C mediated signal transduction, in isolated digestive gland cells of Mytilus galloprovincialis (L )
... of PK and the change in pHi after adrenaline and isoprenaline treatment was investigated (Tables·3, ...and PK activity were similar to β-adrenergic receptor activation in frog and human erythrocytes ...
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Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells
... through PK, indicating that PK is the rate-limiting step in glycolysis during PKM knock- ...down. Pyruvate levels were unchanged, but downstream intermediate lactate was significantly decreased with ...
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Molecular Response of Carbohydrate Metabolism to Dietary Carbohydrate and Acute Low Salinity Stress in Pacific White Shrimp Litopenaeus vannamei
... Dietary polysaccharide can be hydrolyzed to oligosaccharides, branched chain α-dextrin or maltose in the digestive gland of crustaceans (van Wormhoudt and Favrel, 1988), and then is completely hydrolyzed to ...
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In vitro studies on the effect of methanolic extract of Elytraria acaulis on the glucose metabolism of Cotylophoron cotylophorum
... by pyruvate kinase (PK) to pyruvate, which is further reduced to lactate by lactate dehydrogenase ...to pyruvate and part is reduced to succinate through ...
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Alteration of parameters of energy metabolism and ATPase enzymatic system in juvenile common carp (Cyprinus carpio) chronically exposed to tributyltin
... Environmental contaminants inducing physi- ological regulations in organisms are being used as diagnostic tools in assessing potential biological impacts in aquatic systems (Brain and Cedergreen 2009; Li et al. 2011a, ...
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EFFECT OF ETHANOL EXTRACT OF TRACHYSPERMUM AMMI ON PYRUVATE KINASE AND PHOSPHOENOLPYRUVATE CARBOXYKINASE OF COTYLOPHORON COTYLOPHORUM
... enzymes PK and PEPCK of Cotylophoron cotylophorum. PK activity was found to be highly inhibited by ...on PK and PEPCK, of C. cotylophorum. The percentage of inhibition of both PK and PEPCK was ...
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Regulation of Metabolic Pathways PVY-RNA Biosynthesis in Tobacco: Glycolytic Pathway
... and pyruvate kinase (PK), were not influenced by PVY infection (data not shown; the statistical evaluation of paired t-test did not show any statistically significant difference between the healthy ...
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Nutritional regulation and tissue specificity of gene expression for proteins involved in hepatic glucose metabolism in rainbow trout (Oncorhynchus mykiss)
... (6PF-2K/F-2,6BPase), pyruvate kinase (PK), fructose-1,6-bisphosphatase (FBPase) and glucose transporter type 2 (Glut2) gene expression in food- deprived rainbow trout and fed rainbow trout with 20 % ...
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Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia
... DNA analysis was performed on 30 unrelated patients with hereditary nonspherocytic hemolytic anemia (HNSHA) who had been found to be pyruvate kinase (PK) deficient by enzyme assay. 19 different ...
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The role of pyruvate kinase in the regulation of glycolysis and gluconeogenesis in Propionibacterium shermanii : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, New Zealand
... The effect of pH on the rel ati onshi p between pyruvate k i nase acti vi ty and PEP concentrati on . The effect of G6P and ATP on the rel ationshi p between pyruvate k i nase acti vi ty and PEP ...
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Trojans in Wireless Sensor Networks
... The next question we answered in our study is which PKM2 conformation interacts with integrins, dimer or tetramer. In order to test this, we employed Pyruvate kinase synergetic co-activator FBP. FBP ...
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The regulation of some glycolytic enzymes in streptococcus lactis : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, New Zealand
... two pyruvate kina s e s had similar kinetic propert ie s ( Tanaka et ...e kinase wa s de scribe d as a non-allo st eric enzyme (Van Berkel et ...L pyruvate kina s e would fluctuate in re sponse to ...
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Phosphoenolpyruvate Carboxykinase Is Involved in the Decarboxylation of Aspartate in the Bundle Sheath of Maize
... of pyruvate kinase (plus PEP phosphatase) in BS cells is not sufficient to convert all PEP formed by PEPCK into ...into pyruvate by BS strands (Table I) was also lower than the rate of Asp ...of ...
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